其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Paramethasone CAS Registry Number: 53-33-8 帕拉米松

CAS Name: (6a,11b,16a)-6-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
Additional Names: 6a-fluoro-16a-methylprednisolone; 16a-methyl-6a-fluoroprednisolone
Percent Composit...
Literature References: Prepn: Edwards et al., J. Am. Chem. Soc. 82, 2318 (1960). Toxicity study: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).

Oxymethurea CAS Registry Number: 140-95-4 1'3-双羟甲基脲

CAS Name: N,N'-Bis(hydroxymethyl)urea
Additional Names: N,N'-dihydroxymethylurea
Trademarks: Methural
Percent Composition: C 30.00%, H 6.71%, N 23.32%, O 39.96%
Literature References: Prepn: Einhorn, Hamburger, Ber. 41, 26 (1908); Walter, US 1863426 (1927); US 2436355 (1946 to du Pont).

Mepivacaine CAS Registry Number: 96-88-8 甲哌卡因

CAS Name: N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide
Additional Names: 1-methyl-2',6'-pipecoloxylidide; dl-N-methylpipecolic acid 2,6-dimethylanilide; dl-N-methylhexahydropicolinic...
Literature References: Prepn: Ekenstam et al., Acta Chem. Scand. 11, 1183 (1957); US 2799679 (1957 to A. B. Bofors). Prepn of other salts: Rinderknecht, Helv. Chim. Acta 42, 1324 (1959); GB 826668 (1960 to Crookes Labs.). Resolution of isomers: Tullar, J. Med. Chem. 14, 891 (1971); Friberger, Aberg, Acta Pharm. Suec. 8, 361 (1971). Pharmacology: Helmy et al., J. Egypt. Med. Assoc. 50, 688 (1967). Metabolism: Reynolds, Br. J. Anaesth. 43, 33 (1971). Toxicity data: G. Aberg, Acta Pharmacol. Toxicol. 31, 273 (1972).

Thioguanine CAS Registry Number: 154-42-7 硫鸟嘌呤

CAS Name: 2-Amino-1,7-dihydro-6H-purine-6-thione
Additional Names: 2-aminopurine-6-thiol
Trademarks: Lanvis (GSK); Tabloid (GSK)
Percent Composition: C 35.92%, H 3.01%, N 41.89%, S 19.18%
Literature References: Prepn: Elion, Hitchings, J. Am. Chem. Soc. 77, 1676 (1955); Hitchings, Elion, US 2697709; US 2800473; US 2884667; Hitchings et al., US 3019224; US 3132144 (1954, 1957, 1959, 1962, and 1964, all to Burroughs Welcome).

Clobetasone CAS Registry Number: 54063-32-0 氯倍他松

CAS Name: (16b)-21-Chloro-9-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,11,20-trione
Additional Names: 21-chloro-11-dehydrobetamethasone
Percent Composition: C 64.62%, H 6.41%, Cl 8.67%, F...
Literature References: Prepn: Elks et al., DE 1902340; eidem, US 3721687 (1969, l973, both to Glaxo). Activity: Munro, Wilson, Br. Med. J. 3, 626 (1975). Radioimmunoassay: W. A. Webb, R. V. Brooks, Acta Endocrinol. Suppl. 212, 203 (1977). Toxicology: J. Tamura et al., J. Toxicol. Sci. 5, 45, 177 (1980). Comparative clinical studies: A. Lassus, Curr. Med. Res. Opin. 6, 165 (1979); T. Fredriksson, K. Nordin, ibid. 322. Clinical evaluation of ophthalmic form: D. Lloyd-Jones et al., Br. J. Ophthalmol. 65, 641 (1981); L. A. Eilon, S. R. Walker, ibid. 644; K. R. Wilhelmus et al., ibid. 699.

Pentoxyl CAS Registry Number: 147-61-5 4-甲基-5-羟基甲基尿嘧啶

CAS Name: 5-Hydroxymethyl-6-methyl-2,4(1H,3H)-pyrimidinedione
Additional Names: 5-hydroxymethyl-6-methyluracil; 5-hydroxymethyl-4-methyluracil; 4-methyl-5-hydroxymethyluracil
Percent Composi...
Literature References: Prepn: Endicott, Johnson, J. Am. Chem. Soc. 63, 2063 (1941).

Talastine CAS Registry Number: 16188-61-7 他拉斯汀

CAS Name: 2-[2-(Dimethylamino)ethyl]-4-(phenylmethyl)-1(2H)-phthalazinone
Additional Names: 4-benzyl-2-[2-(dimethylamino)ethyl]-1(2H)-phthalazinone
Percent Composition: C 74.24%, H 6.89%, N ...
Literature References: Prepn: Engelbrecht et al., DE 1046625; eidem, US 3017411 (1958, 1962, both to VEB Deutsches Hydrierwerk Rodleben). Pharmacology: D. Lenke, Arzneim.-Forsch. 7, 678 (1957).

Noxiptilin CAS Registry Number: 3362-45-6 诺昔替林

CAS Name: 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-one O-[2-(dimethylamino)ethyl]oxime
Additional Names: 2-[[(10,11-dihydro-5H-dibenz[a,d]cyclohepten-5-ylidene)amino]oxy]-N,N-dimethylethylami...
Literature References: Prepn: Engelhard et al., DE 1198353 (1965); Schutz, Hoffmeister, DE 1225169; Schutz et al., US 3505321 (1966, 1970 both to Bayer); Wrigley, Leeming, GB 1045911 (1966 to Pfizer). Toxicity study: F. Hoffmeister et al., Arzneim.-Forsch. 19, 846 (1969). Series of articles on pharmacology, metabolism, clinical data: ibid. 458-467; 846-878.

Protriptyline CAS Registry Number: 438-60-8 普罗替林

CAS Name: N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine
Additional Names: 5-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene; 7-(3-methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene; amim...
Literature References: Prepn: Engelhardt, Christy, BE 617967 (1962 to Merck Co.), C.A. 59, 517f (1963); Tishler et al., US 3244748 and US 3271451 (both 1966 to Merck Co.); Engelhardt et al., J. Med. Chem. 11, 325 (1968). Metabolism in man, pig and dog: Sisenwine et al., J. Pharmacol. Exp. Ther. 175, 51 (1970). Use in treatment of sleep apnea: R. W. Clark et al., Neurology 29, 1287 (1979); L. G. Brownell et al., N. Engl. J. Med. 307, 1037 (1982).

Sulfabromomethazine CAS Registry Number: 116-45-0 磺胺溴二甲嘧啶

CAS Name: 4-Amino-N-(5-bromo-4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide
Additional Names: N1-(5-bromo-4,6-dimethyl-2-pyrimidinyl)sulfanilamide; 5-bromo-4,6-dimethyl-2-sulfanilamidopyrimidine...
Literature References: Prepn: English et al., J. Am. Chem. Soc. 68, 453 (1946). Pharmacology: C. M. Stowe et al., Am. J. Vet. Res. 29, 345 (1958).