其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Phenoxypropazine CAS Registry Number: 3818-37-9 苯氧丙肼

CAS Name: (1-Methyl-2-phenoxyethyl)hydrazine
Additional Names: fenoxypropazine
Percent Composition: C 65.03%, H 8.49%, N 16.85%, O 9.63%
Literature References: Prepn: Drain et al., J. Med. Chem. 6, 63 (1963).

Tribenoside CAS Registry Number: 10310-32-4 三苄糖苷

CAS Name: Ethyl 3,5,6-tris-O-(phenylmethyl)-D-glucofuranosideTrademarks: Alven (Firma); Flebosan (Dukron); Glyvenol (Novartis); Hemocuron (Takeda); Venex (Recordati)
Percent Composition: C 72.7...
Literature References: Prepn: Druey, Huber, US 3157634 (1964 to Ciba). Pharmacology: Lecomte, C.R. Seances Soc. Biol. Ses Fil. 163, 1469 (1969); Helfer, Jaques, Pharmacology 5, 23 (1971). Increase in capillary resistance in patients with rheumatoid arthritis: W. C. Dick et al., Ann. Rheum. Dis. 28, 187 (1969). GLC determn in plasma: A. Sioufi, F. Pommier, J. Pharm. Sci. 69, 167 (1980). Excretion as hippuric acid: eidem, Eur. J. Drug Metab. Pharmacokinet. 7, 223 (1982). Review of pharmacology: R. Jaques, ibid. 15, 445-460 (1977).

Fluorouracil CAS Registry Number: 51-21-8 5-氟尿嘧啶

CAS Name: 5-Fluoro-2,4(1H,3H)-pyrimidinedione
Additional Names: 2,4-dioxo-5-fluoropyrimidine; 5-FUTrademarks: Adrucil (Adria); Arumel (SS Pharm.); Efudex (Roche); Efudix (Roche); Fluril; Flurac...
Literature References: Prepn: Duschinsky et al., J. Am. Chem. Soc. 79, 4559 (1957); Heidelberger, Duschinsky, US 2802005 (1957); US 2885396 (1959); Barton et al., J. Org. Chem. 37, 329 (1972); O. Miyashita et al., Chem. Pharm. Bull. 29, 3181 (1981). Pharmacokinetics: W. Sadee, C. G. Wong, Clin. Pharmacokinet. 2, 437 (1977). Site of action: F. Maley, G. F. Maley, FEBS Symp. 57, 21 (1979). Comprehensive description: B. C. Rudy, B. Z. Senkowski, Anal. Profiles Drug Subs. 2, 221-244 (1973); S. M. Bayomi, A. A. Al-Badr, ibid. 18, 599-639 (1989). Review of clinical trials: R. M. Hansen, Cancer Invest. 9, 637-642 (1991).

Flucytosine CAS Registry Number: 2022-85-7 5-氟胞嘧啶

CAS Name: 4-Amino-5-fluoro-2(1H)-pyrimidinone
Additional Names: 5-fluorocytosine; 5-FCTrademarks: Alcobon (Roche); Ancobon (Roche); Ancotil (Roche)
Percent Composition: C 37.22%, H 3.12%, F ...
Literature References: Prepn: Duschinsky et al., J. Am. Chem. Soc. 79, 4559 (1957); Heidelberger, Duschinsky, US 2802005 (1957); Duschinsky, Heidelberger, US 2945038 and Duschinsky, US 3040026 (1960, 1962 both to Hoffmann-La Roche); Undheim, Gacek, Acta Chem. Scand. 23, 294 (1969). Patents as a fungicide: Berger, Duschinsky, BE 628615 and US 3368938 (1963, 1968 both to Hoffmann-La Roche). Activity studies: Grunberg et al., Antimicrob. Agents Chemother. 1963, 566; Shadomy et al., ibid. 1968, 452; Grunberg et al., in 5th Int. Congr. Chemother., Proc. vol. IV, K. Spitzy, Ed. (Verlag Wiener Med. Akad., 1967, Austria) p 69. Metabolic studies: Koechlin et al., Biochem. Pharmacol. 15, 435 (1966). Clinical results: Utz et al., Antimicrob. Agents Chemother. 1968, 344; Warner et al., ibid. 1970, 473. Comprehensive description: E. H. Waysek, J. H. Johnson, Anal. Profiles Drug Subs. 5, 115-138 (1976).

Broparoestrol CAS Registry Number: 479-68-5 溴帕雌烯

CAS Name: 1-(2-Bromo-1,2-diphenylethenyl)-4-ethylbenzene
Additional Names: 1-bromo-2-(p-ethylphenyl)-1,2-diphenylethylene; 1-bromo-2-(4-ethylphenyl)-1,2-diphenylethene; a-bromo-a,b-diphenyl-b-(...
Literature References: Prepn: Dvolaitsky, Jacques, Bull. Soc. Chim. Biol. 40, 939 (1958).

Potassium p-Aminobenzoate CAS Registry Number: 138-84-1 对氨基苯甲酸钾

CAS Name: p-Aminobenzoic acid potassium salt
Additional Names: potassium para-aminobenzoate; KPABA
Trademarks: Potaba (Glenwood)
Percent Composition: C 47.98%, H 3.45%, K 22.31%, N 7.99%,...
Literature References: Prepn: E. A. Meyers et al., J. Am. Chem. Soc. 89, 3565 (1967). Crystal structure: G. S. Ciminago, C.R. Seances Acad. Sci. Ser. C 267, 1402 (1968). Antifibrotic efficacy in idiopathic pulmonary fibrosis: U. H. Cegla et al., Pneumonologie 152, 75 (1975); in Peyronie's disease: A. J. Riley, Br. J. Sex. Med. 6, 29 (1970); G. Williams, N. A. Green, Br. J. Urol. 52, 392 (1980).

Fepradinol CAS Registry Number: 63075-47-8 非普地醇

CAS Name: a-[[(2-Hydroxy-1,1-dimethylethyl)amino]methyl]benzenemethanol
Additional Names: 1-phenyl-2-(a,a-dimethylethanolamino)ethanol
Percent Composition: C 68.87%, H 9.15%, N 6.69%, O 15.2...
Literature References: Prepn: E. Biekert, J. Sonnenbichler, Ber. 95, 1451 (1962); G. Staibano, C. Protto, Farmaco Ed. Sci. 27, 929 (1972); G. Staibano, BE 774629 (1972 to Gentili). Pharmacology: J. M. Masso et al., J. Pharm. Pharmacol. 45, 959 (1993). Mechanism of action study: eidem, Arzneim.-Forsch. 44, 68 (1994). Clinical trial: C. Bestit et al., Curr. Ther. Res. 45, 53 (1989).

Chlorpropham CAS Registry Number: 101-21-3 氯苯胺灵

CAS Name: (3-Chlorophenyl)carbamic acid 1-methylethyl ester
Additional Names: m-chlorocarbanilic acid isopropyl ester; isopropyl-m-chlorocarbanilate; isopropyl N-(3-chlorophenyl)carbamate; chlo...
Literature References: Prepn: E. D. Witman, US 2695225; Strain, US 2734911 (1954, 1956 both to Columbia-Southern Chem.); Brockway, US 2806051 (1957 to B. F. Goodrich). Toxicology: E. M. Boyd, E. Carsky, Arch. Environ. Health 19, 621 (1969).

N-Methyltaurine CAS Registry Number: 107-68-6 N-甲基牛磺酸

CAS Name: 2-Methylaminoethanesulfonic acid
Additional Names: b-methylaminoethane-a-sulfonic acid
Percent Composition: C 25.89%, H 6.52%, N 10.06%, O 34.49%, S 23.04%
Literature References: Prepn: E. Dittrich, J. Prakt. Chem. 18, 63 (1878); J. W. Schick, E. F. Degering, Ind. Eng. Chem. 39, 906 (1947).

Methyl Isopropyl Ketone CAS Registry Number: 563-80-4 甲基异丙基甲酮

CAS Name: 3-Methyl-2-butanone
Additional Names: 2-acetylpropane
Percent Composition: C 69.72%, H 11.70%, O 18.58%
Literature References: Prepn: E. Frankland, B. F. Duppa, Ann. 138, 328 (1866). Large scale prepn: T. W. Mears et al., J. Res. Natl. Bur. Stand. 44, 299 (1950). Miscibility profile: W. M. Jackson, J. S. Drury, Ind. Eng. Chem. 51, 1491 (1959). Thermodynamic properties: J. L. Hales et al., Trans. Faraday Soc. 63, 1876 (1967). Acute toxicity: H. Tanii et al., Toxicol. Lett. 30, 13 (1986).