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Dibenzepin CAS Registry Number: 4498-32-2 二苯西平

CAS Name: 10-[2-(Dimethylamino)ethyl]-5,10-dihydro-5-methyl-11H-dibenzo[b,e][1,4]diazepin-11-one
Additional Names: 5-methyl-10b-dimethylaminoethyl-10,11-dihydro-11-oxodibenzo[b,e][1,4]diazepinePercent Composition: C 73.19%, H 7.17%, N 14.23%, O 5.42%

📌 参考资料/链接：
Literature References: Prepn: F. Hunziker et al., Arzneim.-Forsch. 13, 324 (1963); GB 961106; J. Schmutz, F. Hunziker, US 3312689 and US 3419547 (1964, 1967, 1968 all to Wander). Metabolism: H. Lehner et al., Arzneim.-Forsch. 17, 185 (1967). Comprehensive description: A. Egli, W. R. Michaelis, Anal. Profiles Drug Subs. 9, 181-206 (1980).

📄 详细内容

Properties: mp 116-117°. bp0.01 185°.
Melting point: mp 116-117°
Boiling point: bp0.01 185°
Derivative Type: Hydrochloride
CAS Registry Number: 315-80-0
Trademarks: Neodalit (HÝsle); Noveril (Morishita)
Percent Composition: C 65.15%, H 6.68%, N 12.66%, O 4.82%, Cl 10.68%
Properties: Crystals, mp 238°. uv max (0.1N HCl): 204, 220 nm (log e 4.530, 4.458). pKa 8.25. Sol in water, alcohol, chloroform. LD50 orally in mice: 215 mg/kg (Hunziker).
Melting point: mp 238°
pKa: pKa 8.25
Absorption maximum: uv max (0.1N HCl): 204, 220 nm (log e 4.530, 4.458)
Toxicity data: LD50 orally in mice: 215 mg/kg (Hunziker)
Therap-Cat: Antidepressant.
Keywords: Antidepressant; Tricyclics.
产品链接: 4498-32-2››

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