其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Norethynodrel CAS Registry Number: 68-23-5 异炔诺酮

CAS Name: (17a)-17-Hydroxy-19-norpregn-5(10)-en-20-yn-3-one
Additional Names: 17a-ethynyl-17-hydroxy-5(10)-estren-3-one; 13-methyl-17-ethynyl-17-hydroxy-1,2,3,4,6,7,8,9,11,12,13,14,16,17-tetrad...
Literature References: Prepn: Colton, US 2691028, US 2725389 (1954, 1955 to Searle). Metabolism studies in mice: Freudenthal et al., Toxicol. Appl. Pharmacol. 24, 125 (1973).

Bolandiol CAS Registry Number: 19793-20-5 勃雄二醇

CAS Name: (3b,17b)-Estr-4-ene-3,17-diol
Additional Names: 3b,17b-dihydroxyestr-4-ene
Percent Composition: C 78.21%, H 10.21%, O 11.58%
Literature References: Prepn: Colton, US 2843608 (1958 to Searle).

Beryllium Carbide CAS Registry Number: 506-66-1 乙炔化铍

Percent Composition: C 39.98%, Be 60.00%
Literature References: Prepn: Coobs, Koshuba, J. Electrochem. Soc. 99, 115 (1952); Mallett et al., ibid. 101, 298 (1954); Ehrlich in Handbook of Preparative Inorganic Chemistry vol. 1, G. Brauer, Ed. (Academic Press, New York, 2nd ed., 1963) p 899.

Vinbarbital Sodium CAS Registry Number: 125-44-0 5-乙基-5-(1-甲基-1-丁烯基)-2-钠氧基-4,6(1H,5H)-嘧啶二酮

CAS Name: 5-Ethyl-5-(1-methyl-1-butenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione sodium salt
Additional Names: 5-ethyl-5-(1-methyl-1-butenyl)barbituric acid sodium salt; sodium 5-ethyl-5-(1-methyl-1-b...
Literature References: Prepn: Cope, Hancock, J. Am. Chem. Soc. 61, 776 (1939); Cope, US 2187703 (1940 to Sharp Dohme). Pharmacology and toxicity: J. P. Hendrix, J. Pharmacol. Exp. Ther. 68, 22 (1940).

Hexylcaine Hydrochloride CAS Registry Number: 532-76-3 海克卡因盐酸盐

CAS Name: 1-(Cyclohexylamino)-2-propanol benzoate (ester) hydrochlorideTrademarks: Cyclaine (Merck Co.)
Percent Composition: C 64.53%, H 8.12%, Cl 11.90%, N 4.70%, O 10.74%
Literature References: Prepn: Cope, Hancock, J. Am. Chem. Soc. 66, 1453 (1944); Cope, US 2486374 (1949 to Sharp Dohme). Pharmacokinetics: R. M. Rodgers et al., Res. Commun. Chem. Pathol. Pharmacol. 29, 99 (1980).

Thenium Closylate CAS Registry Number: 4304-40-9 西尼铵氯苯磺酸

CAS Name: N,N-Dimethyl-N-(2-phenoxyethyl)-2-thiophenemethanaminium salt with 4-chlorobenzenesulfonic acid (1:1)
Additional Names: dimethyl(2-phenoxyethyl)-2-thenylammonium p-chlorobenzenesulfon...
Literature References: Prepn: Copp, GB 864885 (1961 to Wellcome Found.). Anthelmintic activity: Burrows, Lillis, Am. J. Vet. Res. 23, 77 (1962).

Bretylium Tosylate CAS Registry Number: 61-75-6 托西溴苄铵

CAS Name: 2-Bromo-N-ethyl-N,N-dimethylbenzenemethanaminium salt with 4-methylbenzenesulfonic acid (1:1)
Additional Names: (o-bromobenzyl)ethyldimethylammonium p-toluenesulfonate; N-ethyl-N-o-br...
Literature References: Prepn: Copp, Stephenson, US 3038004 (1962 to Burroughs Wellcome). Metabolism: R. Kuntzman et al., Clin. Pharmacol. Ther. 11, 829 (1970). Toxicity study: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971). Review of pharmacology: R. H. Heissenbuttel, J. T. Bigger, Ann. Intern. Med. 91, 229-238 (1979); R. J. Lee et al., in Pharmacological and Biochemical Properties of Drug Substances vol. 2, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1979) pp 148-164. Comprehensive description: J. E. Carter et al., Anal. Profiles Drug Subs. 9, 71-86 (1980).

n-Amyl Mercaptan CAS Registry Number: 110-66-7 正戊硫醇

CAS Name: 1-Pentanethiol
Additional Names: amyl thioalcohol
Percent Composition: C 57.63%, H 11.61%, S 30.77%
Literature References: Prepn: Cossar et al., J. Org. Chem. 27, 93 (1962).

Methopterin CAS Registry Number: 2410-93-7 氨甲叶酸杂质C

CAS Name: N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Additional Names: N-[4-[[(2-amino-4-hydroxy-6-pteridinyl)methyl]methylamino]benzoyl]glutamic...
Literature References: Prepn: Cosulich, Smith, J. Am. Chem. Soc. 70, 1922 (1948); Cosulich, US 2563707 (1951 to Am. Cyanamid).

Azacosterol CAS Registry Number: 313-05-3 阿扎胆醇

CAS Name: (3b,17b)-17-[[3-(Dimethylamino)propyl]methylamino]androst-5-en-3-ol
Additional Names: N-methyl-N-[3-(dimethylamino)propyl]-17b-aminoandrost-5-en-3b-ol; 20,25-diazacholesterol; diazast...
Literature References: Prepn: Counsell et al., J. Med. Pharm. Chem. 5, 1224 (1962); Counsell, Klimstra, US 3084156 (1963 to Searle).