其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Bis(1,2-dimethylpropyl)borane CAS Registry Number: 1069-54-1 二(3-甲基丁烷-2-基)硼烷

Additional Names: Disiamylborane; di-sec-isoamylborine; bis(3-methyl-2-butyl)borane
Percent Composition: C 77.94%, H 15.04%, B 7.02%
Literature References: Prepn: Brown, Zweifel, J. Am. Chem. Soc. 83, 1241 (1961). Use in selective reductions: G. W. Kabalka, C. F. Lane, Chem. Tech. 6, 324 (1976).

Pentaerythritol Chloral CAS Registry Number: 78-12-6 2,2,2-三氯-1-[3-(2,2,2-三氯-1-羟基-乙氧基)-2,2-二[(2,2,2-三氯-1-羟基-乙氧基)甲基]丙氧基]乙醇

CAS Name: 1,1'-[2,2-Bis[(2,2,2-trichloro-1-hydroxyethoxy)methyl]-1,3-propanediylbis(oxy)]bis[2,2,2-trichloroethanol]
Trademarks: Petrichloral; Periclor (Ives)
Percent Composition: C 21.52%, ...
Literature References: Prepn: Bruce, US 2784237 (1957 to Am. Home Prod.).

tert-Butyl Bromide CAS Registry Number: 507-19-7 溴代叔丁烷

CAS Name: 2-Bromo-2-methylpropane
Additional Names: 2-bromoisobutane; trimethylbromomethane
Percent Composition: C 35.06%, H 6.62%, Br 58.32%
Literature References: Prepn: Brunel, J. Am. Chem. Soc. 39, 1978 (1917); Bryce-Smith, Howlett, J. Chem. Soc. 1951, 1141; Coe et al., ibid. 1954, 2281.

Bis(2-ethylhexyl) Sebacate CAS Registry Number: 122-62-3 癸二酸二辛酯

CAS Name: Decanedioic acid bis(2-ethylhexyl) ester
Additional Names: di(2-ethylhexyl) sebacate
Trademarks: Octoil S; Plexol 201
Percent Composition: C 73.19%, H 11.81%, O 15.00%
Literature References: Prepn: Bruno, US 2628249 (1953 to Pittsburgh Coke Chemical); GB 747260 (1956 to Chemische Werke Hüls).

Lethane® 384 (Rohm & Haas) CAS Registry Number: 112-56-1 丁氧硫氰醚

CAS Name: Thiocyanic acid 2-(2-butoxyethoxy)ethyl ester
Additional Names: 2-butoxy-2'-thiocyanodiethyl ether; 2-[2-(butoxy)ethoxy]ethyl ester of thiocyanic acid; butyl carbitol rhodanate; 1-but...
Literature References: Prepn: Bruson, US 2372809 (1945 to Rohm Haas).

Ambucaine CAS Registry Number: 119-29-9 氨布卡因

CAS Name: 4-Amino-2-butoxybenzoic acid 2-diethylaminoethyl ester
Additional Names: 2-butoxy-4-aminobenzoic acid b-diethylaminoethyl ester; b-diethylaminoethyl 2-butoxy-4-aminobenzoate; 2-diethy...
Literature References: Prepn: Büchi et al., Helv. Chim. Acta 34, 1002 (1951); Clinton et al., J. Am. Chem. Soc. 74, 592 (1952); Clinton, Laskowski, US 2689248 (1954 to Sterling Drug); Grimme, Schmitz, Ber. 87, 179 (1954).

Mofebutazone CAS Registry Number: 2210-63-1 单苯基保泰松

CAS Name: 4-Butyl-1-phenyl-3,5-pyrazolidinedione
Additional Names: 4-butyl-1-phenyl-3,5-dioxopyrazolidine; 2-phenyl-3,5-dihydroxy-4-butylpyrazolidine; monophenylbutazone
Trademarks: Arcomono...
Literature References: Prepn: Büchi et al., Helv. Chim. Acta 36, 75 (1953); GB 839057 (1960 to Comm. Farm. Milanese). Toxicity data: Schoetensack, Arch. Exp. Pathol. Pharmakol. 233, 365 (1958).

Chlorindanol CAS Registry Number: 145-94-8 4-氯-7-羟基氢化茚

CAS Name: 7-Chloro-2,3-dihydro-1H-inden-4-ol
Additional Names: 7-chloro-4-indanol
Percent Composition: C 64.11%, H 5.38%, Cl 21.03%, O 9.49%
Literature References: Prepn: Buck et al., J. Am. Chem. Soc. 79, 3559 (1957); Buck, US 2990324 (1961 to Esta Med. Labs.).

Chlorproethazine CAS Registry Number: 84-01-5 氯丙沙嗪

CAS Name: 2-Chloro-N,N-diethyl-10H-phenothiazine-10-propanamine
Additional Names: 2-chloro-10-(3-diethylaminopropyl)phenothiazine; 3-chloro-10-(3-diethylaminopropyl)phenothiazinePercent Composi...
Literature References: Prepn: Buisson et al., US 2769002 (1956 to Rhône-Poulenc).

Tiocarlide CAS Registry Number: 910-86-1 硫卡利特

CAS Name: N,N'-[4-(3-Methylbutoxy)phenyl]thiourea
Additional Names: 4,4'-bis(isopentyloxy)thiocarbanilide; 4,4'-di(isoamyloxy)thiocarbanilide; 1,3-bis(p-isoamyloxyphenyl)-2-thiourea; thiocarlid...
Literature References: Prepn: Buu-Hoi, Xuong, Compt. Rend. 237, 498 (1953); Huebner, Scholz, US 2703815 (1955 to Ciba).