其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Dimetridazole CAS Registry Number: 551-92-8 二甲硝咪唑

CAS Name: 1,2-Dimethyl-5-nitro-1H-imidazoleTrademarks: Emtryl (Rhe-Poulenc); Unizole
Percent Composition: C 42.55%, H 5.00%, N 29.77%, O 22.67%
Literature References: Prepn: Bhagwat, Pyman, J. Chem. Soc. 127, 1832 (1925).

DMPA CAS Registry Number: 299-85-4 N-[(2,4-二氯苯氧基)-甲氧基硫代膦酰]丙-2-胺

CAS Name: (1-Methylethyl)phosphoramidothioic acid O-(2,4-dichlorophenyl) O-methyl ester
Additional Names: isopropylphosphoramidothioic acid O-2,4-(dichlorophenyl) O-methyl ester; O-(2,4-dichlor...
Literature References: Prepn: Blair et al., J. Agric. Food Chem. 11, 237 (1963). Synthesis of the optical isomers: Seiber, Tolkmith, Tetrahedron 25, 381 (1969). Use as a herbicide: Leasure, US 3074790 (1963 to Dow); as a plant growth regulator: Holmsen, Weed Sci. 17, 187 (1969). Neurotoxicity in chickens: B. M. Francis et al., J. Environ. Sci. Health B15, 313 (1980). Toxicity study: E. W. Schafer, Toxicol. Appl. Pharmacol. 21, 315 (1972).

Becanthone CAS Registry Number: 15351-04-9 1-({2-[乙基(2-羟基-2-甲基丙基)氨基]乙基}氨基)-4-甲基-9H-噻吨-9-酮

CAS Name: 1-[[2-[Ethyl(2-hydroxy-2-methylpropyl)amino]ethyl]amino]-4-methyl-9H-thioxanthen-9-one
Additional Names: becantone
Percent Composition: C 68.72%, H 7.34%, N 7.29%, O 8.32%, S 8.34%
Literature References: Prepn: Blanz, French, J. Med. Chem. 6, 185 (1963).

Xenbucin CAS Registry Number: 959-10-4 联苯丁酸

CAS Name: a-Ethyl-[1,1'-biphenyl]-4-acetic acid
Additional Names: 2-(4-biphenylyl)butyric acid; a-(4-biphenylyl)butyric acid; a-(4-diphenylyl)butyric acid; a-(p-xenyl)butyric acid; 4-diphenylyl...
Literature References: Prepn: Blicke, Grier, J. Am. Chem. Soc. 65, 1725 (1943); Cavallini, Massarani, Farmaco Ed. Sci. 11, 167 (1956). Fibrinolytic activity: R. J. Gryglewski, M. Eckstein, Nature 214, 626 (1967).

Potassium Tetrabromoaurate(III) CAS Registry Number: 13966-47-7

Additional Names: Gold potassium bromide; potassium auribromide
Percent Composition: Au 35.45%, Br 57.52%, K 7.04%
Literature References: Prepn: Block, Inorg. Synth. 4, 14 (1953).

Proxibarbal CAS Registry Number: 2537-29-3 丙羟巴比

CAS Name: 5-(2-Hydroxypropyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Additional Names: 5-allyl-5-(2-hydroxypropyl)barbituric acid; 5-allyl-5-(b-hydroxypropyl)barbituric acid; 5-allyl-5...
Literature References: Prepn: Bobranski et al., Rocz. Chem. 30, 175 (1956), C.A. 51, 438f (1957); GB 953387 (1964 to Hommel A.G.), C.A. 61, 3123a (1964); Smissman et al., J. Med. Chem. 14, 853 (1971). Metabolism: Bobranski et al., Arch. Immunol. Ther. Exp. 10, 895 (1962); B. Lambrey et al., Eur. J. Med. Chem. - Chim. Ther. 15, 463 (1980). Pharmacokinetics: eidem, ibid. 12, 565 (1977).

Fenpiprane CAS Registry Number: 3540-95-2 1-(3,3-二苯丙基)哌啶

CAS Name: 1-(3,3-Diphenylpropyl)piperidine
Additional Names: 1,1-diphenyl-3-piperidinopropane; 1-(3,3-biphenylpropyl)piperidine; 1,1-diphenyl-3-pentamethyleneiminopropane
Percent Composition...
Literature References: Prepn: Bockmühl, Ehrhart, Ann. 561, 52 (1948); US 2446522 (1948 to Winthrop-Stearns); Ruddy, Buckley, J. Am. Chem. Soc. 72, 718 (1950); Ruddy, Becker, US 2662886 (1953 to Winthrop-Stearns).

Tolpropamine CAS Registry Number: 5632-44-0 托普帕敏

CAS Name: N,N,4-Trimethyl-g-phenylbenzenepropanamine
Additional Names: N,N-dimethyl-3-phenyl-3-p-tolylpropylamine; 3-dimethylamino-1-phenyl-1-p-tolylpropane
Percent Composition: C 85.32%, H ...
Literature References: Prepn: Bockmühl, Stein, DE 925468 (1955 to Hoechst); Klosa, J. Prakt. Chem. 34, 312 (1966). Pharmacology: Sendrail, Gleizes, Therapie 15, 119 (1960).

Dimorpholamine CAS Registry Number: 119-48-2 双吗啉胺

CAS Name: N,N'-1,2-Ethanediylbis[N-butyl-4-morpholinecarboxamide]
Additional Names: N,N'-dibutyl-N,N'-dicarboxymorpholideethylenediamine; N,N'-dibutyl-N,N'-dicarboxyethylene diaminemorpholideTr...
Literature References: Prepn: Boon, J. Chem. Soc. 1947, 307; idem, US 2398283 and US 2409829 (both 1946 to I.C.I.). Toxicity data: Y. Kasé et al., Arch. Int. Pharmacodyn. Ther. 163, 133 (1966).

Acetylene Dichloride CAS Registry Number: 540-59-0 二氯乙烯

CAS Name: 1,2-Dichloroethene
Additional Names: 1,2-dichloroethylene; sym-dichloroethylene; dioform
Percent Composition: C 24.78%, H 2.08%, Cl 73.14%
Literature References: Prepn: Bordner, US 2504919 (1950 to du Pont). Prepn of trans-form: Adler, US 2440997 (1948 to Stockholms Superfosfot Fabriks Aktiebolag). Sepn of cis- and trans-forms by fractional distillation: Wood, Dickinson, J. Am. Chem. Soc. 61, 3259 (1939); Johnsen, Fitzpatrick, Rec. Trav. Chim. 70, 823 (1951); Truce, Barney, J. Org. Chem. 27, 128 (1962). Toxicity studies: D. Gradiski et al., Eur. J. Toxicol. 7, 247 (1974); K. J. Freundt et al., Toxicology 7, 141 (1977). Review: V. L. Stevens in Kirk-Othmer Encyclopedia of Chemical Technology Vol. 5 (Wiley-Interscience, New York, 3rd ed., 1979) pp 742-745. Review of toxicology and human exposure: Toxicological Profile for 1,2-Dichloroethene (PB95-100152, 1996) 198 pp.