其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Indapamide CAS Registry Number: 26807-65-8 吲达帕胺

CAS Name: 3-(Aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)benzamide
Additional Names: 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide; N-(3-sulfamyl-4-chlorobenzamido)-2...
Literature References: Prepn: Beregi et al., FR 2003311; eidem, US 3565911 (1969, 1971, both to Sci. Union et Cie, Soc. Franc. Recherche Med.). LC/MS determn in plasma: F. Albu et al., J. Chromatogr. B 816, 35 (2005). Pharmacology: Leary et al., Curr. Ther. Res. 15, 571 (1973); D. B. Campbell, R. A. Moore, Postgrad. Med. J. Suppl. 57, 7 (1981). Acute toxicity data: J. Kyncl et al., Arzneim.-Forsch. 25, 1491 (1975). Symposium on pharmacology and clinical efficacy: Am. J. Med. 84, Suppl. 1B, 1-111 (1988); Am. J. Cardiol. 65, Suppl. H, 1H-80H (1990). Comprehensive description: T. J. DiFeo, J. E. Shuster, Anal. Profiles Drug Subs. Excip. 23, 229-268 (1994).

Flurogestone Acetate CAS Registry Number: 2529-45-5 醋酸氟孕酮

CAS Name: (11b)-17-(Acetyloxy)-9-fluoro-11-hydroxypregn-4-ene-3,20-dione
Additional Names: 9-fluoro-11b,17-dihydroxypregn-4-ene-3,20-dione-17-acetate; 17a-acetoxy-9a-fluoro-11b-hydroxyprogester...
Literature References: Prepn: Bergstrom et al., J. Am. Chem. Soc. 81, 4432 (1959); Bergstrom, Dodson; Bergstrom, Nicholson, US 2892851; US 2963498 (1959, 1960 to Searle).

Ammonium Picrate CAS Registry Number: 131-74-8 2,4,6-三硝基苯酚铵

CAS Name: 2,4,6,-Trinitrophenol ammonium salt
Additional Names: picric acid ammonium salt; ammonium picronitrate; ammonium carbazoate
Percent Composition: C 29.28%, H 2.46%, N 22.76%, O 45.5...
Literature References: Prepn: Berl, Berl, US 2350322 (1944). Crystal structure: Maartmann-Moe, Acta Crystallogr. 25B, 1452 (1969).

Oxycinchophen CAS Registry Number: 485-89-2 羟辛可芬

CAS Name: 3-Hydroxy-2-phenyl-4-quinolinecarboxylic acid
Additional Names: 3-hydroxy-2-phenylcinchoninic acid; 3-hydroxycinchophen; HPC
Trademarks: Fenidrone; Magnofenyl; Magnophenyl; Oxinofe...
Literature References: Prepn: Berlingozzi, Capuano, Atti Accad. Lincei [V] 33, II, 91 (1924); John, Fränkel, J. Prakt. Chem. 133, 259 (1932); improved procedure: Marshall, Blanchard, J. Pharmacol. 95, 186 (1949); Kreysa, US 2776290 (1957 to Chemo Puro).

Nicergoline CAS Registry Number: 27848-84-6 尼麦角林

CAS Name: (8b)-10-Methoxy-1,6-dimethylergoline-8-methanol 5-bromo-3-pyridinecarboxylate (ester)
Additional Names: 1-methyllumilysergol 8-(5-bromonicotinate) 10-methyl ether; 4,6,6a,7,8,9,10,10a...
Literature References: Prepn: Bernardi et al., US 3228943; Temperilli, DE 2112273 (1966, 1971, both to Farmitalia); Arcari et al., Experientia 28, 819 (1972). Series of articles on pharmacology, clinical studies, tolerability: Arzneim.-Forsch. 29, 1213-1316 (1979). Toxicity study: B. W. Neumann, F. Lauschner, ibid. 1206. Hemodynamic effects in the dog: ibid. 31, 1693 (1981). Use in acute myocardial infarction with diastolic hypertension: E. Triulzi et al., Farmaco Ed. Prat. 36, 449 (1981).

Triamcinolone CAS Registry Number: 124-94-7 曲安西龙

CAS Name: (11b, 16a)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
Additional Names: D1-9a-fluoro-16a-hydroxyhydrocortisone; 9a-fluoro-16a-hydroxyprednisolone; D1-16a-hydroxy-9a-...
Literature References: Prepn: Bernstein et al., J. Am. Chem. Soc. 78, 5693 (1956); 81, 1689 (1959); Thoma et al., ibid. 79, 4818 (1957); Bernstein et al., Allen et al., US 2789118; US 3021347 (1957, 1962, both to Am. Cyanamid). Comprehensive description: K. Florey, Anal. Profiles Drug Subs. 1, 367-396, 423-442 (1972); D. H. Sieh, ibid. 11, 593-614, 651-661 (1982).

Halcinonide CAS Registry Number: 3093-35-4 哈西奈德

CAS Name: (11b,16a)-21-Chloro-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione
Additional Names: 21-chloro-9-fluoro-11b,16a,17-trihydroxypregn-4-ene-3,20-dione cyc...
Literature References: Prepn: Bernstein et al., J. Org. Chem. 27, 690 (1962); L. T. Difazio, M. A. Augustine, DE 2355710; eidem, US 3892857 (1972, 1975 both to Squibb). Pharmacological evaluation: Bagatell, Augustine, Curr. Ther. Res. 16, 748 (1974); R. C. Millonig, E. Yiakas, in Pharmacological and Biochemical Properties of Drug Substances vol. 1, M. E. Goldberg, Ed. (Am. Pharmaceut. Assoc., Washington, DC, 1977) pp 215-231. Comprehensive description: J. Kirshbaum, Anal. Profiles Drug Subs. 8, 251-281 (1979).

Moxestrol CAS Registry Number: 34816-55-2 甲氧炔雌醇

CAS Name: (11b,17a)-11-Methoxy-19-nor-17-pregna-1,3,5(10)-trien-20-yne-3,17-diol
Additional Names: 3,17-dihydroxy-11b-methoxy-19-nor-17a-pregna-1,3,5-trien-20-yne; 17a-ethynyl-11b-methoxyestra-...
Literature References: Prepn: Bertin, Pierdet, ZA 6703381; eidem, US 3579545; FR M6182, C.A. 72, 90739m (1970) (1968, 1971, 1968 all to Roussel-UCLAF); Azadian-Boulanger, Bertin, Chim. Ther. 8, 451 (1973). Activity studies: Raynaud, Steroids 21, 249 (1973); Raynaud et al., Mol. Pharmacol. 9, 520 (1973).

Beryllium Formate CAS Registry Number: 1111-71-3

CAS Name: Formic acid beryllium salt
Percent Composition: C 24.25%, H 2.04%, Be 9.10%, O 64.61%
Literature References: Prepn: Besson, Hardt, Compt. Rend. 238, 355 (1954).

Xanthinol Niacinate CAS Registry Number: 437-74-1 烟酸占替诺

CAS Name: 3-Pyridinecarboxylic acid compd with 3,7-dihydro-7-[2-hydroxy-3-[(2-hydroxyethyl)methylamino]propyl]-1,3-dimethyl-1H-purine-2,6-dione (1:1)
Additional Names: 7-[2-hydroxy-3-[(2-hydrox...
Literature References: Prepn: Bestian, DE 1102750 (1961 to Wuelfing), C.A. 56, 11602i (1962). Alternate synthesis: Korbonits et al., Acta Pharm. Hung. 38, 98 (1968). Pharmacology: Hemmer, Diezemann, Arzneim.-Forsch. 12, 672 (1962); Lennartz, ibid. 675; Stamm, ibid. 679.