其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

o-Cresotic Acid CAS Registry Number: 83-40-9 邻甲基水杨酸

CAS Name: 2-Hydroxy-3-methylbenzoic acid
Additional Names: 2,3-cresotic acid; o-homosalicylic acid; o-cresotinic acid; 2-hydroxy-m-toluic acid; 3-methylsalicylic acid
Percent Composition: C ...
Literature References: Prepn: Baine et al., J. Org. Chem. 19, 510 (1954); Jones, Chem. Ind. (London) 1958, 228; Blicke, McCarty, J. Org. Chem. 24, 1061 (1959); Wessely et al., Ber. 93, 2840 (1960).

tert-Butyl Acetate CAS Registry Number: 540-88-5 醋酸叔丁酯

CAS Name: Acetic acid 1,1-dimethylethyl ester
Additional Names: acetic acid tert-butyl ester
Percent Composition: C 62.04%, H 10.41%, O 27.55%
Literature References: Prepn: Baker, Bordwell; Hauser et al., Org. Synth. coll. vol. III, 141, 142 (1955). Manuf from acetic acid and isobutylene: Young, Pare, US 3031495 (1962 to Sinclair); Wheeler et al., US 3102905 (1963 to Celanese); Heisler et al., US 3096365 (1963 to Texaco); Faith, Keyes Clark's Industrial Chemicals, F. A. Lowenheim, M. K. Moran, Eds. (Wiley-Interscience, New York, 4th ed., 1975) pp 171-177.

Nickel Dimethylglyoxime CAS Registry Number: 13478-93-8 二甲基乙二肟镍(II)

CAS Name: Bis[(2,3-butanedione dioximato)(1-)-N,N']nickel
Additional Names: bis(dimethylglyoximato)nickel
Percent Composition: C 33.26%, H 4.88%, N 19.39%, Ni 20.32%, O 22.15%
Literature References: Prepn: Banks et al., J. Am. Chem. Soc. 77, 324 (1955); F. J. Welcher, Organic Analytical Reagents vol. 3 (Van Nostrand, New York, 1947) pp 165-179; Thabet et al., Inorg. Nucl. Chem. Lett. 8, 211 (1972). Structure: Godycki, Rundle, Acta Crystallogr. 6, 487 (1953); Merritt, Anal. Chem. 25, 718 (1953).

Aluminum Hexaurea Sulfate Triiodide CAS Registry Number: 15304-14-0 六(脲-O)铝(3+)三碘化硫酸酯

CAS Name: (OC-6-11)-Hexakis(urea-O)aluminum(3+) sulfate (triiodide)(1:1:1)
Additional Names: aluminum hexacarbamide sulfate triiodide
Trademarks: Alure
Percent Composition: C 8.34%, H 2.8...
Literature References: Prepn: Barbieri, Atti R. Accad. Lincei 24, 919 (1915); Morris et al., Ind. Eng. Chem. 45, 1013 (1953).

Benzodepa CAS Registry Number: 1980-45-6 苯佐替派

CAS Name: [Bis(1-aziridinyl)phosphinyl]carbamic acid phenylmethyl ester
Additional Names: benzyl [bis(1-aziridinyl)phosphinyl]carbamate; benzyl bis(ethylenimido)phosphorourethan; benzcarbimineT...
Literature References: Prepn: Bardos et al., Nature 183, 399 (1959); Papanastassiou, Bardos, J. Med. Pharm. Chem. 5, 1000 (1962).

Bacitracin Methylenedisalicylate CAS Registry Number: 1405-88-5

CAS Name: Bacitracin methylenebis[2-hydroxybenzoate] (salt)
Additional Names: bacitracin methylenedisalicylic acid
Trademarks: BMD (Alpharma); Solu-Tracin (Alpharma)
Literature References: Prepn: Baron, US 2774712 (1956 to S. B. Penick Co.). LC determn in animal feed: G. K. Webster, J. AOAC Int. 80, 732 (1997). Efficacy as growth promotant: A. L. Izat et al., Poult. Sci. 69, 1787 (1990); in combination with anticoccidial agents: H. D. Chapman et al., Avian Pathol. 27, 498 (1998).

Barthrin CAS Registry Number: 70-43-9 (6-氯苯并[1,3]二氧杂环戊烯-5-基)甲基2,2-二甲基-3-(2-甲基丙-1-烯基)环丙烷-1-羧酸酯

CAS Name: 2,2-Dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylic acid (6-chloro-1,3-benzodioxol-5-yl) methyl ester
Additional Names: 2,2-dimethyl-3-(2-methylpropenyl)cyclopropanecarboxylic ...
Literature References: Prepn: Barthel, Alexander, J. Org. Chem. 23, 1012 (1958); Barthel et al., US 2886485 (1959).

Phthalylsulfacetamide CAS Registry Number: 131-69-1 酞磺醋胺

CAS Name: 2-[[[4-[(Acetylamino)sulfonyl]phenyl]amino]carbonyl]benzoic acid
Additional Names: 4'-(acetylsulfamyl)phthalanilic acid; phthalylsulfacetimide; N1-acetyl-N4-phthaloylsulfanilamide; N1...
Literature References: Prepn: Basu, J. Indian Chem. Soc. 26, 130 (1949).

Tristriphenylphosphine Rhodium Carbonyl Hydride CAS Registry Number: 17185-29-4 三(三苯基膦)羰基氢化铑(I)

CAS Name: Carbonylhydrotris(triphenylphosphine)rhodium
Additional Names: hydridocarbonyltris(triphenylphosphine)rhodium(I)
Percent Composition: C 71.90%, H 5.05%, O 1.74%, P 10.11%, Rh 11.20...
Literature References: Prepn: Bath, Vaska, J. Am. Chem. Soc. 85, 3500 (1963); Levison, Robinson, J. Chem. Soc. A 1970, 2947; Ahmad et al., J. Chem. Soc. Dalton Trans. 1972, 843; Ahmad et al., Inorg. Synth. 15, 45 (1974). Structure: LaPlaca, Ibers, J. Am. Chem. Soc. 85, 3501 (1963); eidem, Acta Crystallogr. 18, 511 (1965). Chemistry: Evans et al., J. Chem. Soc. A 1968, 2660; O'Connor, Wilkinson, ibid. 2665.

Chloroprednisone CAS Registry Number: 52080-57-6 氯泼尼松

CAS Name: (6a)-Chloro-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
Additional Names: 6a-chloro-1,4-pregnadiene-17a,21-diol-3,11,20-trione
Percent Composition: C 64.20%, H 6.41%, Cl 9.02%, ...
Literature References: Prepn: Batres et al., DE 1079042 (1960 to Syntex). Prepn of the 21-acetate by selenium dioxide dehydrogenation of 6a-chlorocortisone 21-acetate: Ringold et al., J. Am. Chem. Soc. 80, 6464 (1958); Ringold, Rosenkranz, US 2957895 (1960 to Syntex).