其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Bupivacaine CAS Registry Number: 2180-92-9 丁吡卡因

CAS Name: 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide
Additional Names: dl-1-butyl-2',6'-pipecoloxylidide; 1-n-butyl-2',6'-dimethyl-2-piperidinecarboxanilide; dl-N-n-butylpipecolic a...
Literature References: Prepn: B. Ekenstam et al., Acta Chem. Scand. 11, 1183 (1957); B. T. Ekenstam, B. G. Pettersson, US 2955111 (1960 to AB Bofors). Resolution of isomers: B. F. Tullar, J. Med. Chem. 14, 891 (1971). Stereospecific synthesis: B. Adger et al., Tetrahedron Lett. 37, 6399 (1996). Pharmacology of racemate: F. Henn, R. Brattsand, Acta Anaesthesiol. Scand. Suppl. 21, 9 (1966), C.A. 66, 17863u (1967); of isomers: F. P. Luduena et al., Arch. Int. Pharmacodyn. 200, 359 (1972). Clinical pharmacokinetics: D. W. Blake et al., Anaesth. Intensive Care 22, 522 (1994). Comprehensive description: T. D. Wilson, Anal. Profiles Drug Subs. 19, 59-94 (1990). Review of use in spinal anesthesia: Acta Anaesthesiol. Scand. 35, 1-10 (1991). Review of pharmacology and clinical efficacy of levobupivacaine: K. J. McClellan, C. M. Spencer, Drugs 56, 355-362 (1998).

TMD CAS Registry Number: 60761-10-6 2-萘酚,十氢1,1,4a-三甲基-,(2R,4aR,8aS)-rel-

CAS Name: Decahydro-1,1,4a-trimethyl-2-naphthalenol
Additional Names: 1,1,10-trimethyl-trans-2-decalol; 4,4,10b-trimethyl-trans-decal-3b-ol
Percent Composition: C 79.53%, H 12.32%, O 8.15%
Literature References: Prepn: B. Gaspert et al., J. Chem. Soc. 1958, 624; C. Djerassi, D. Marshall, J. Am. Chem. Soc. 80, 3986 (1958); T. G. Halsall et al., J. Chem. Soc. 1959, 2798; S. L. Mukherjee, P. C. Dutta, ibid. 1960, 67. Inhibitor of cholesterol biosynthesis: J. A. Nelson et al., J. Am. Chem. Soc. 100, 4900 (1978); T.-Y. Chang et al., J. Biol. Chem. 254, 11258 (1979).

Parsalmide CAS Registry Number: 30653-83-9 帕沙米特

CAS Name: 5-Amino-N-butyl-2-(2-propynyloxy)benzamide
Additional Names: 5-amino-O-propynyl-N-butylsalicylamide; 2-propargyloxy-5-amino-N-butylbenzamideTrademarks: Sinovial (Irbi); Parsal (Midy)<...
Literature References: Prepn: B. Gradnik et al., DE 2029991; eidem, US 3739030 (1970, 1973 both to Soc. Etude Recher. Sci. Med.). Synthesis and pharmacology: A. Pedrazzoli et al., Boll. Chim. Farm. 115, 125 (1976). Effect on gastric secretion in laboratory animals: G. Bertaccini et al., Farmaco Ed. Prat. 34, 482 (1979). Inhibition of platelet aggregation: R. Fantasia et al., Arzneim.-Forsch. 32, 1312 (1982). Clinical comparison with phenylbutazone, q.v., in management of joint pain: A. Bajardi, S. Fantato, Minerva Med. 67, 3371 (1976); S. Menci et al., ibid. 3403. Series of articles on anti-inflammatory activity, pharmacology and toxicology: Boll. Chim. Farm. 115, 135-230 (1976), C.A. 85, 13981-13986 (1976).

Dimethirimol CAS Registry Number: 5221-53-4 二甲嘧酚

CAS Name: 5-Butyl-2-(dimethylamino)-6-methyl-4(1H)-pyrimidinone
Additional Names: 5-butyl-2-(dimethylamino)-6-methyl-4-pyrimidinol; 2-dimethylamino-4-methyl-5-n-butyl-6-hydroxypyrimidineTradema...
Literature References: Prepn: B. K. Snell et al., ZA 6701373; eidem, US 3980781 (1968, 1976 both to ICI). Systemic fungicidal activity: R. S. Elias, Nature 219, 1160 (1968); K. J. Bent, Ann. Appl. Biol. 66, 103 (1970). Metabolism and mode of action: A. Calderbank, Acta Phytopathol. 6, 355 (1971). Metabolism: H. Bratt et al., Food Cosmet. Toxicol. 10, 489 (1972).

Sevoflurane CAS Registry Number: 28523-86-6 氟甲基-1,1,1,3,3,3-六氟异丙基醚

CAS Name: 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane
Additional Names: fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether; fluoromethyl 1,1,1,3,3,3-hexafluoro-2-propyl ether
Tr...
Literature References: Prepn: B. M. Regan, J. C. Longstreet, DE 1954268; eidem, US 3689571 (1970, 1972 both to Baxter Labs.). Pharmacology and physicochemical properties: R. F. Wallin et al., Anesth. Analg. 54, 758 (1975). Clinical pharmacology and metabolism: D. A. Holaday, F. R. Smith, Anesthesiology 54, 100 (1981). Toxicity study: D. P. Strum et al., Anesth. Analg. 66, 769 (1987). Minimum alveolar concentration (MAC) in man: T. Katoh, K. Ikeda, Anesthesiology 66, 301 (1987). Preliminary clinical evaluation in pheochromocytoma: M. Doi, K. Ikeda, ibid. 70, 360 (1989).

Dimethyl Carbonate CAS Registry Number: 616-38-6 碳酸二甲酯

CAS Name: Carbonic acid dimethyl ester
Additional Names: methyl carbonate
Percent Composition: C 40.00%, H 6.71%, O 53.28%
Literature References: Prepn: B. Röse, Ann. 205, 227 (1880); V. Grignard et al., Ann. Chim. (Paris) 9, 229 (1920). Review of mfr and characteristics as a fuel additive: M. A. Pacheco, C. L. Marshall, Energy Fuels 11, 2-29 (1997); of synthesis and chemical reactions: Y. Ono, Appl. Catal. A 155, 133-166 (1997); of production and eco-friendly applications: D. Delledonne et al., ibid. 221, 241-251 (2001); and chemistry: P. Tundo, M. Selva, Acc. Chem. Res. 35, 706-716 (2002).

Metolazone CAS Registry Number: 17560-51-9 美托拉宗

CAS Name: 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide
Additional Names: 7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide;...
Literature References: Prepn: B. V. Shetty, US 3360518 (1967 to Wallace Tiernan); B. V. Shetty et al., J. Med. Chem. 13, 886 (1970). Pharmacology: E. Belair et al., Arch. Int. Pharmacodyn. Ther. 177, 71 (1969); E. J. Belair, Res. Commun. Chem. Pathol. Pharmacol. 2, 98 (1971). HPLC determn in urine: D. Farthing et al., J. Chromatogr. 534, 228 (1990). Clinical evaluations as diuretic in chronic renal disease: R. Schoonees et al., N. Y. State J. Med. 71, 566 (1971); in hypertension: C. L. Curry et al., Clin. Ther. 9, 47 (1986); in congestive heart failure: A. Kiyingi et al., Lancet 335, 29 (1990).

Chlorphentermine CAS Registry Number: 461-78-9 对氯苯丁胺

CAS Name: 4-Chloro-a,a-dimethylbenzeneethanamine
Additional Names: 4-chloro-a,a-dimethylphenethylamine; a,a-dimethyl-p-chlorophenethylamine; 1-(p-chlorophenyl)-2-methyl-2-propylamine; 1-(p-chlo...
Literature References: Prepn: Bachman et al., J. Am. Chem. Soc. 76, 3972 (1954); Ferrari, Farmaco Ed. Sci. 15, 337 (1960); FR M1299 and FR 1296132 (1962 to Simes), C.A. 58, 4467e, 3352g (1963); GB 90633l (1962 to Kefalas), C.A. 58, 6654c (1963). Pharmacology: Jun et al., Can. J. Pharm. Sci. 4, 27 (1969); Ciborska et al., Acta Pol. Pharm. 26, 595 (1969); Moeller-Nielsen, Dubnick, Proc. Int. Symp. Amphetamines Relat. Compounds 1969, E. Costa, Ed. (Raven Press, New York, 1970) pp 63-73.

Inositol Niacinate CAS Registry Number: 6556-11-2 肌醇烟酸酯

CAS Name: myo-Inositol hexa-3-pyridinecarboxylate
Additional Names: hexanicotinoyl inositol; hexanicotinyl cis-1,2,3,5-trans-4,6-cyclohexane; inositol hexanicotinate; meso-inositol hexanicotina...
Literature References: Prepn: Badgett, Woodward, J. Am. Chem. Soc. 69, 2907 (1947).

Hydantoin CAS Registry Number: 461-72-3 乙内酰脲

CAS Name: 2,4-Imidazolidinedione
Additional Names: 2,4-(3H,5H)-imidazoledione; glycolylurea
Percent Composition: C 36.00%, H 4.03%, N 27.99%, O 31.97%
Literature References: Prepn: Baeyer, Ann. 130, 129 (1864). Manuf: Gresham, Schweitzer, US 2402134 (1946 to du Pont); White, Wysong, US 2663713 (1953 to Dow). Review: J. H. Bateman in Kirk-Othmer Encyclopedia of Chemical Technology vol. 12 (Wiley-Interscience, New York, 3rd ed., 1980) pp 692-711.