其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Octabenzone CAS Registry Number: 1843-05-6 2-羟基-4-正辛氧基二苯甲酮

CAS Name: [2-Hydroxy-4-(octyloxy)phenyl]phenylmethanone
Additional Names: 2-hydroxy-4-(octyloxy)benzophenone; benzophenone-12
Trademarks: Spectra-Sorb UV 531 (Am. Cyanamid)
Percent Compos...
Literature References: Prepn: Armitage et al., US 3098842 (1963 to du Pont).

Carbocysteine CAS Registry Number: 638-23-3 羧甲司坦

CAS Name: S-(Carboxymethyl)-L-cysteine
Additional Names: 3-[(carboxymethyl)thio]alanine; S-carboxymethylcysteineTrademarks: Carbocit (CT); Fluifort (Domp?; Lisomucil (Sanofi-Synthelabo); Lovisc...
Literature References: Prepn: Armstrong, Lewis, J. Org. Chem. 16, 749 (1951); Schöberl, Wagner, Z. Physiol. Chem. 304, 97 (1956); Foye, Verderame, J. Am. Pharm. Assoc. 46, 273 (1957); Goodman et al., J. Org. Chem. 23, 1251 (1958). Pharmacology: Huyen-Vu-Ngoc et al., C.R. Seances Soc. Biol. Ses Fil. 160, 1849 (1966); Quevauviller et al., Therapie 22, 485 (1967). Clinical trial in chronic bronchitis: M. Grillage, K. Bernard-Jones, Br. J. Clin. Pract. 39, 395 (1985). Review of pharmacology and clinical uses: D. T. Brown, Drug Intell. Clin. Pharm. 22, 603-608 (1988).

Metyridine CAS Registry Number: 114-91-0 2-(2-甲氧基乙基)吡啶

CAS Name: 2-(b-Methoxyethyl)pyridine
Additional Names: methyridine
Trademarks: Dekelmin; Promintic (Ayerst)
Percent Composition: C 70.04%, H 8.08%, N 10.21%, O 11.66%
Literature References: Prepn: Arnall, Greenhalgh, GB 889748 (1962 to ICI and Midland Tar Distillers); US 3223710 (1965).

Defosfamide CAS Registry Number: 3733-81-1 地磷酰胺

CAS Name: N,N-Bis(2-chloroethyl)-N'-(3-hydroxypropyl)phosphorodiamidic acid 2-chloroethyl ester
Additional Names: 2-chloroethyl N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)phosphorodiamidate; N,...
Literature References: Prepn: Arnold et al, DE 1061780 (1959 to Asta-Werke).

Chlorphenoxamine CAS Registry Number: 77-38-3 氯苯沙明

CAS Name: 2-[1-(4-Chlorophenyl)-1-phenylethoxy]-N,N-dimethylethanamine
Additional Names: 2-[(p-chloro-a-methyl-a-phenylbenzyl)oxy]-N,N-dimethylethylamine; b-dimethylaminoethyl (p-chloro-a-methy...
Literature References: Prepn: Arnold et al., US 2785202 (1957 to Asta-Werke). Synthesis: G. Cahiez et al., Tetrahedron Lett. 29, 3659 (1988). Pharmacology: eidem, Arzneim.-Forsch. 4, 189 (1954); Brock et al., ibid. 262. Toxicity studies: Kerley et al., Toxicol. Appl. Pharmacol. 4, 638 (1962). Metabolism: C. Koppel et al., Arzneim.-Forsch. 37, 1062 (1987). GC-MS determn in urine: H. Maurer, K. Pfleger, J. Chromatogr. 428, 43 (1988).

Demanyl Phosphate CAS Registry Number: 6909-62-2 2-二甲基氨基乙基磷酸酯

CAS Name: Mono[2-(dimethylamino)ethyl]phosphoric acid ester
Additional Names: 2-dimethylaminoethanol dihydrogen phosphate; phosphoryldimethylaminoethanol; phosphoryldimethylcolamine; phosphoryl...
Literature References: Prepn: Aron-Samuel et al., FR 992802 (1951), C.A. 51, 458e (1957); Cherbuliez, Rabinowitz, Helv. Chim. Acta 41, 1168 (1958); GB 861463; US 3098072 (1961, 1963 to Ciba). The phosphate ester of a possible choline precursor. Has been isolated from a choline-requiring mutant of Neurospora crassa, strain 47904: Wolf, Nyc, J. Biol. Chem. 234, 1068 (1959). Biosynthetic studies: Ansell, Chojnacki, Nature 196, 545 (1962); eidem, Biochem. J. 98, 303 (1966).

Imolamine CAS Registry Number: 318-23-0 伊莫拉明

CAS Name: 4-[2-(Diethylamino)ethyl]-5-imino-3-phenyl-D2-1,2,4-oxadiazoline
Additional Names: 3-phenyl-4-diethylaminoethyl-5-imino-1,2,4-oxadiazoline
Percent Composition: C 64.59%, H 7.74%, N...
Literature References: Prepn: Aron-Samuel, Sterne, FR M2023 (1963), C.A. 60, 2952f (1964). Pharmacology: Molino, Belluardo, Gazz. Int. Med. Chir. 71, 2100 (1966), C.A. 66, 74830e (1967).

Dexamethasone CAS Registry Number: 50-02-2 地塞米松

CAS Name: (11b,16a)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
Additional Names: 9a-fluoro-16a-methylprednisolone; 16a-methyl-9a-fluoro-1,4-pregnadiene-11b,17a,21-triol-3...
Literature References: Prepn: Arth et al., J. Am. Chem. Soc. 80, 3161 (1958); Oliveto et al., ibid. 4431; Muller et al., US 3007923 (1961 to Lab. Franc. Chimiothér.); Arth et al., DE 1113690 (1961 to Merck Co.); GB 869511 (to Upjohn). Pharmacology in guinea pigs: L. Zicha et al., Arzneim.-Forsch. 10, 831 (1960). Clinical trial of anti-emetic efficacy in chemotherapy-induced nausea: M. Markman et al., N. Engl. J. Med. 311, 549 (1984); in combination with ondansetron, q.v.: F. Roila et al., ibid. 342, 1554 (2000). Use as diagnostic aid in depression: B. J. Carroll et al., Arch. Gen. Psychiatry 38, 15 (1981); P. P. Hubain et al., Neuropsychobiology 16, 57 (1986); M. Ansseau et al., ibid. 68. Comprehensive description: E. M. Cohen, Anal. Profiles Drug Subs. 2, 163-197 (1973). Reviews of diagnostic use in Cushing's syndrome: L. Crapo, Metabolism 28, 955 (1979); in depression: L. Braddock, Br. J. Psychiatry 148, 363 (1986).

Amphotalide CAS Registry Number: 1673-06-9 氨苯酞胺

CAS Name: 2-[5-(4-Aminophenoxy)pentyl]-1H-isoindole-1,3(2H)-dione
Additional Names: N-[5-(p-aminophenoxy)pentyl]phthalimide; 1-p-aminophenoxy-5-phthalimidopentane; amphothalideTrademarks: Schis...
Literature References: Prepn: Ashley et al., J. Chem. Soc. 1959, 3880; Barber et al., GB 769706 (1957 to May Baker).

Morantel CAS Registry Number: 20574-50-9 莫仑太尔

CAS Name: (E)-1,4,5,6-Tetrahydro-1-methyl-2-[2-(3-methyl-2-thienyl)ethenyl]pyrimidine
Percent Composition: C 65.41%, H 7.32%, N 12.71%, S 14.55%
Literature References: Prepn: Austin et al., GB 1120587 (1968 to Pfizer).