其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Lanoconazole CAS Registry Number: 101530-10-3 拉诺康唑

CAS Name: (E)-(±)-a-[4-(2-Chlorophenyl)-1,3-dithiolan-2-ylidene]-1H-imidazole-1-acetonitrile
Additional Names: latoconazoleTrademarks: Astat (Nihon Nohyaku)
Percent Composition: C 52.57...
Literature References: Prepn: A. Soe et al., JP Kokai 85 218387; idem et al., US 4636519 (1985, 1987 both to Nihon Nohyaku). In vivo antifungal activity: H. Oka et al., Arzneim.-Forsch. 42, 345 (1992); Y. Niwano et al., Antimicrob. Agents Chemother. 38, 2204 (1994). Toxicity study: P. L. Munt et al., Oyo Yakuri 43, 195 (1992).

Aceclofenac CAS Registry Number: 89796-99-6 醋氯芬酸

CAS Name: 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid carboxymethyl ester
Additional Names: 2-[(2,6-dichlorophenyl)amino]phenylacetoxyacetic acid; glycolic acid [o-(2,6-dichloroanilino)phen...
Literature References: Prepn: A. V. Casas, ES 8404783; idem, US 4548952 (1984, 1985 both to Prodes). Gastrointestinal tolerance in rats in comparison with diclofenac, q.v.: V. Rimbau et al., Farmaco Ed. Prat. 43, 19 (1988). Clinical trial in comparison with acetaminophen, q.v., in episiotomal pain: A. Yscla, Drugs Exp. Clin. Res. 14, 491 (1988). Clinical evaluation in rheumatoid arthritis: R. Ballesteros et al., Clin. Trials J. 27, 12 (1990).

Hexethal Sodium CAS Registry Number: 144-00-3 己巴比妥钠

CAS Name: 5-Ethyl-5-hexyl-2,4,6(1H,3H,5H)-pyrimidinetrione monosodium salt
Additional Names: sodium 5-ethyl-5-hexylbarbiturate
Trademarks: Ortal Sodium; Hebaral
Percent Composition: C 54....
Literature References: Prepn: A. W. Dox, US 1624546. Anesthetic properties and toxicity data: C. M. Gruber, J. T. Brundage, J. Pharmacol. Exp. Ther. 60, 439 (1937).

Trientine CAS Registry Number: 112-24-3 三乙烯四胺

CAS Name: N,N'-Bis(2-aminoethyl)-1,2-ethanediamine
Additional Names: triethylenetetramine; 1,8-diamino-3,6-diazaoctane; 3,6-diazaoctane-1,8-diamine; 1,4,7,10-tetraazadecane; trien; TETA; TECZA<...
Literature References: Prepn: A. W. von Hoffmann, Ber. 23, 3711 (1890); J. van Alphen, Rec. Trav. Chim. 55, 412 (1936); G. D. Jones et al., J. Org. Chem. 9, 125 (1944); of the dihydrochloride: H. B. Dixon et al., Lancet 1, 853 (1972). Effects on the metabolism of copper in rats: F. W. Sunderman et al., Toxicol. Appl. Pharmacol. 38, 177 (1976); H. Harders et al., Arzneim.-Forsch. 30, 254 (1980). Use of the dihydrochloride in the treatment of Wilson's disease: J. M. Walshe, Prog. Clin. Biol. Res. 34, 271 (1979); R. H. Haslam et al., Dev. Pharmacol. Ther. 1, 318 (1980); J. M. Walshe, Lancet 1, 643 (1982). Review of chemistry, physical properties and industrial uses: R. D. Spitz, "Diamines and Higher Amines, Aliphatic" in Kirk-Othmer Encyclopedia of Chemical Technology vol. 7 (Wiley-Interscience, New York, 3rd ed., 1979) pp 580-602. Review: J. M. Walshe, Orphan Drugs, F. E. Karch, Ed. (Marcel Dekker, New York, 1982) pp 57-71.

Pentaerythritol Tetranitrate CAS Registry Number: 78-11-5 戊四硝酯

CAS Name: 2,2-Bis[(nitrooxy)methyl]-1,3-propanediol dinitrate (ester)
Additional Names: pentaerythrityl tetranitrate; 2,2-bisdihydroxymethyl-1,3-propanediol tetranitrate; PETN; nitropentaerythr...
Literature References: Prepn: Acken, Vyverberg, US 2370437 (1945 to Du Pont). GC/MS analysis in post-explosion residues: T. Tamiri et al. in Adv. Anal. Detect. Explosives, J. Yinon, Ed. (Kluwer, Netherlands, 1993) pp 323-334.

Trifenmorph CAS Registry Number: 1420-06-0 杀螺吗啉

CAS Name: 4-(Triphenylmethyl)morpholine
Additional Names: 4-tritylmorpholineTrademarks: Frescon (Shell)
Percent Composition: C 83.86%, H 7.04%, N 4.25%, O 4.86%
Literature References: Prepn: Adams et al., US 3577413 (1971 to Shell). Lab tests as molluscicide: Webbe, Sturrock, Ann. Trop. Med. Parasitol. 58, 234 (1964); C.A. 61, 15286g (1964). Field trials and toxicity: Boyce et al., Nature 210, 1140 (1966). Degradn: K. I. Beynon et al., Pestic. Sci. 3, 689 (1972). Neurophysiological action: R. B. Morton, D. R. Gardner, Experientia 32, 611 (1976).

Isobutyl p-Aminobenzoate CAS Registry Number: 94-14-4 4-氨基苯甲酸异丁酯

CAS Name: 4-Aminobenzoic acid 2-methylpropyl ester
Trademarks: Cycloform; Isobutyl Kelo-form; Isocaine (Columbus)
Percent Composition: C 68.37%, H 7.82%, N 7.25%, O 16.56%
Literature References: Prepn: Adams et al., J. Am. Chem. Soc. 48, 1758 (1926).

Paranyline CAS Registry Number: 1729-61-9 雷尼托林

CAS Name: 4-(9H-Fluoren-9-ylidenemethyl)benzenecarboximidamide
Additional Names: a-fluoren-9-ylidene-p-toluamidine; 9-(p-guanylbenzylidene)fluorene; 9-(p-guanylbenzal)fluorenePercent Compositio...
Literature References: Prepn: Allen et al., J. Am. Chem. Soc. 80, 591 (1958); Van Campen et al., US 2877269 (1959 to Wm. S. Merrell).

Amphenone B CAS Registry Number: 2686-47-7 3,3-二(4-氨基苯基)丁烷-2-酮

CAS Name: 3,3-Bis[4-aminophenyl]-2-butanone
Additional Names: amphenone; 2-oxo-3,3-bis[p-aminophenyl]butane
Percent Composition: C 75.56%, H 7.13%, N 11.01%, O 6.29%
Literature References: Prepn: Allen, Corwin, J. Am. Chem. Soc. 72, 117 (1950); US 2539388 (1951). Structure: Bencze, Allen, J. Org. Chem. 22, 352 (1957). Shows antiestrogenic activity in the chick oviduct test: Hertz et al., Recent Prog. Horm. Res. 11, 119-147 (1955). Decreases adrenal action. Review: Subsidia Med. 10, 99-102 (1958).

Triparanol CAS Registry Number: 78-41-1 曲帕拉醇

CAS Name: 4-Chloro-a-[4-[2-(diethylamino)ethoxy]phenyl]-a-(4-methylphenyl)benzeneethanol
Additional Names: 1-[p-(2-diethylaminoethoxy)phenyl]-1-(p-tolyl)-2-(p-chlorophenyl)ethanol; 2-(p-chlorop...
Literature References: Prepn: Allen, Palopoli et al., US 2914562 (1959 to Wm. S. Merrell).