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Lanoconazole CAS Registry Number: 101530-10-3 拉诺康唑

CAS Name: (E)-(±)-a-[4-(2-Chlorophenyl)-1,3-dithiolan-2-ylidene]-1H-imidazole-1-acetonitrile
Additional Names: latoconazoleTrademarks: Astat (Nihon Nohyaku)
Percent Composition: C 52.57%, H 3.15%, Cl 11.08%, N 13.14%, S 20.05%

📌 参考资料/链接：
Literature References: Prepn: A. Soe et al., JP Kokai 85 218387; idem et al., US 4636519 (1985, 1987 both to Nihon Nohyaku). In vivo antifungal activity: H. Oka et al., Arzneim.-Forsch. 42, 345 (1992); Y. Niwano et al., Antimicrob. Agents Chemother. 38, 2204 (1994). Toxicity study: P. L. Munt et al., Oyo Yakuri 43, 195 (1992).

📄 详细内容

Properties: Light yellow crystals, mp 141.5°. LD50 in male, female mice, rats (mg/kg): 3224, 2715, 993, 652 orally; 2158, 1743, 1655, 2596 i.p.; 5000 both species s.c. LD50 dermally in rats: 5000 mg/kg (Munt).
Melting point: mp 141.5°
Toxicity data: LD50 in male, female mice, rats (mg/kg): 3224, 2715, 993, 652 orally; 2158, 1743, 1655, 2596 i.p.; 5000 both species s.c.; LD50 dermally in rats: 5000 mg/kg (Munt)
Therap-Cat: Antifungal.
Keywords: Antifungal (Synthetic); Imidazoles.
产品链接: 101530-10-3››

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