其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Stilbamidine CAS Registry Number: 122-06-5 司替巴脒

CAS Name: 4,4'-(1,2-Ethenediyl)bisbenzenecarboximidamide
Additional Names: 4,4'-stilbenedicarboxamidine; 4,4'-diamidinostilbene
Percent Composition: C 72.70%, H 6.10%, N 21.20%
Literature References: Prepn: A. J. Ewins, J. N. Ashley, GB 510097 (1939 to May Baker); J. N. Ashley et al., J. Chem. Soc. 1942, 103; of isethionate: G. Newbery, A. P. T. Easson, US 2394003 (1946 to May Baker). Trypanocidal activity: E. M. Lourie, W. Yorke, Ann. Trop. Med. Parasitol. 33, 289 (1939). Preliminary pharmacology: R. Wien, ibid. 37, 1 (1943). Mechanism of action studies: M. J. Pine, Biochem. Pharmacol. 17, 75 (1968); G. Weissmann et al., ibid. 19, 1251 (1970). Crystal structure: C. Courseille et al., C.R. Seances Acad. Sci. Ser. C 272, 1115 (1971). DNA binding study: N. Gresh, B. Pullman, Mol. Pharmacol. 25, 452 (1984). Early review of pharmacology, mode of action and clinical applications: E. B. Schoenbach, E. M. Greenspan, Medicine 27, 327-377 (1948).

Sulfapyridine CAS Registry Number: 144-83-2 磺胺吡啶

CAS Name: 4-Amino-N-2-pyridinylbenzenesulfonamide
Additional Names: dagenan; N1-2-pyridylsulfanilamide; 2-sulfanilamidopyridine; 2-(p-aminobenzenesulfonamido)pyridinePercent Composition: C 53.0...
Literature References: Prepn: A. J. Ewins, M. A. Phillips, GB 512145 (1939); eidem, US 2275354 (1942); R. Winterbottom, J. Am. Chem. Soc. 62, 160 (1940). Metabolism: R. Wien, J. Hampton, J. Pharmacol. Exp. Ther. 84, 211 (1945). Toxicology: R. Wien et al., ibid. 203. GC-MS determn in edible animal tissues: A. E. Mooser, H. Koch, J. AOAC Int. 76, 976 (1993). Efficacy and proposed mechanism of action in dermatological disease: O. J. Stone, Med. Hypotheses 31, 99 (1990). Clinical evaluation in ocular cicatricial pemphigoid: M. J. Elder et al., Br. J. Ophthalmol. 80, 549 (1996).

Enciprazine CAS Registry Number: 68576-86-3 恩西拉嗪

CAS Name: 4-(2-Methoxyphenyl)-a-[(3,4,5-trimethoxyphenoxy)methyl]-1-piperazineethanol
Additional Names: (±)-1-[3-(3,4,5-trimethoxyphenoxy)-2-hydroxypropyl]-4-(2-methoxyphenyl)piperazine Literature References: Prepn: A. Kleemann et al., DE 2814168; eidem, US 4335126 (1978, 1982 both to Degussa). Synthesis and pharmacology: J. Engel et al., J. Med. Chem. 33, 2976 (1990). Metabolism in rats: E. Benfenati et al., J. Pharm. Pharmacol. 39, 312 (1987). Clinical evaluation as anxiolytic: G. Scheibe et al., Arzneim.-Forsch. 40, 644 (1990); E. Schweizer et al., Psychopharmacol. Bull. 26, 215 (1990).

Bupirimate CAS Registry Number: 41483-43-6 乙嘧酚磺酸酯

CAS Name: Dimethylsulfamic acid 5-butyl-2-(ethylamino)-6-methyl-4-pyrimidinyl ester
Additional Names: 5-butyl-2-(ethylamino)-6-methyl-4-pyrimidinyl dimethylsulfamateTrademarks: Nimrod (Syngenta...
Literature References: Prepn: A. M. Cole et al., DE 2246645; eidem, US 3880852 (1973, 1975 both to ICI). Activity: J. R. Finney et al., Proc. 8th Br. Insectic. Fungic. Conf. 2, 667 (1975).

Fenofibrate CAS Registry Number: 49562-28-9 非诺贝特

CAS Name: 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid 1-methylethyl ester
Additional Names: isopropyl [4'-(p-chlorobenzoyl)-2-phenoxy-2-methyl]propionate; procetofen; procetofeneTrade...
Literature References: Prepn: A. Mieville, DE 2250327 (1973 to Orchimed), C.A. 79, 53029 (1973), addn to DE 2003430; eidem, US 4058552 (1970, 1977 both to Orchimed). Series of articles on synthesis, metabolism, pharmacology and clinical trials: Arzneim.-Forsch. 26, 885-909 (1976). Toxicity data: R. Sornay et al., ibid. 885. GC-MS of major metabolite in humans: L. F. Elsom et al., J. Chromatogr. 123, 463 (1976). Efficacy in hyperlipidemias: H. B. Stähelin et al., Praxis 68, 24 (1979). Effect on human biliary lipids: E. M. Grandjean et al., Schweiz. Med. Wochenschr. 109, 601 (1979). Mechanism of action: W. Wülfert et al., Artery 9, 120 (1981).

Azosemide CAS Registry Number: 27589-33-9 2-氯-5-(2H-四唑-5-基)-4-((噻吩-2-基甲基)氨基)苯磺酰胺

CAS Name: 2-Chloro-5-(1H-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]benzenesulfonamide
Additional Names: 2-chloro-5-(2H-tetrazol-5-yl)-N4-2-thenylsulfanilamide; 5-(4'-chloro-2'-thenylamino-5'-sul...
Literature References: Prepn: A. Popelak et al., DE 1815922; eidem, US 3665002 (1968, 1972 both to Boehringer, Mann.). Separation and analysis in blood and urine by HPLC: R. Seiwell, C. Brater, J. Chromatogr. 182, 257 (1980). Sites of action: C. Brater, Clin. Pharmacol. Ther. 25, 428 (1979). Clinical and pharmacological studies: F. Krueck et al., Eur. J. Clin. Pharmacol. 14, 153 (1978). Diuretic effect in animals: J. Greven, O. Heidenreich, Arzneim.-Forsch. 31, 346, 350 (1981).

Bensuldazic Acid CAS Registry Number: 1219-77-8 苄硫嗪酸

CAS Name: 5-Benzyldihydro-6-thioxo-2H-1,3,5-thiadiazine-3(4H)-acetic acid
Additional Names: ujothionPercent Composition: C 51.04%, H 5.00%, N 9.92%, O 11.33%, S 22.71%
Literature References: Prepn: A. Rieche et al., Arch. Pharm. 296, 770 (1963); W. Schade et al., DD 31793 (1964), C.A. 63, 16370g (1965). Antimicrobial activity: M. Schorr et al., Arzneim.-Forsch. 19, 1807 (1969). Efficacy vs ringworm in cattle: B. Vujic, Berl. Muench. Tieraerztl. Wochenschr. 84, 144 (1971).

p-Phenylenediamine CAS Registry Number: 106-50-3 对苯二胺

CAS Name: 1,4-Benzenediamine
Additional Names: p-diaminobenzene; p-aminoaniline; orsin; C.I. 76076
Trademarks: Ursol D
Percent Composition: C 66.64%, H 7.46%, N 25.90%
Literature References: Prepn: A. Rinne, T. Zincke, Ber. 7, 869 (1874); DE 202170 (1907 to BASF), C.A. 3, 382 (1909); A. J. Quick, J. Am. Chem. Soc. 42, 1033 (1920); J. F. Norris, E. O. Cummings, Beilstein 17, 305 (1925). See also: Beilstein XIII, 61 (1930). Crystal structure: A. Domenicano et al., Acta Crystallogr. B33, 1664 (1977). Mutagenicity studies: B. N. Ames et al., Proc. Natl. Acad. Sci. USA 72, 2423 (1975); W. G. H. Blijleven, Mutat. Res. 48, 181 (1977). Toxicity study: C. Burnett et al., J. Toxicol. Environ. Health 2, 657 (1977).

Butoctamide CAS Registry Number: 32838-26-9 N-(2-乙基己基)-3-羟基丁酰胺

CAS Name: N-(2-Ethylhexyl)-3-hydroxybutanamide
Additional Names: N-(2-ethylhexyl)-3-hydroxybutyramide; hexobutyramide
Percent Composition: C 66.93%, H 11.70%, N 6.50%, O 14.86%
Literature References: Prepn: A. Sakuma et al., FR 8393; eidem, US 3639457; eidem, JP Kokai 79 24822, C.A. 91, 34947f (1979) (1971, 1972, 1979 all to Lion Dentifrice). Toxicology study: M. Kato et al., Oyo Yakuri 17, 287 (1979), C.A. 91, 68665e (1979). Acute toxicity: R. Goshima et al., Toho Igakkai Zasshi 17, 579 (1970), C.A. 74, 138765n (1971). Clinical effect on rapid eye movement (REM) sleep: Y. Hayashi et al., Psychopharmacology 77, 367 (1982); in Down's syndrome: J. C. Grubar et al., ibid. 90, 119 (1986).

Diisopropylamine CAS Registry Number: 108-18-9 二异丙胺

CAS Name: N-(1-Methylethyl)-2-propanamine
Percent Composition: C 71.22%, H 14.94%, N 13.84%
Literature References: Prepn: A. Siersch, Ann. 148, 263 (1868); M. Van der Zande, Rec. Trav. Chim. 8, 202 (1889). Enthalpy of formation: M. A. V. Ribeiro da Silva et al., J. Chem. Thermodyn. 29, 1025 (1997). Toxicity study: H. F. Smyth et al., Arch. Ind. Hyg. Occup. Med. 10, 61 (1954). Safety assessment: J. Am. Coll. Toxicol. 14, 182-192 (1995).