Properties: Liquid; characteristic odor; strongly alkaline. d22 0.722. bp 84°. Flash pt, open cup: 21°F (-6℃). Sol in water, alc. LD50 orally in rats: 0.77 g/kg (Smyth).
Boiling point: bp 84°
Flash point: Flash pt, open cup: 21°F (-6℃)
Density: d22 0.722
Toxicity data: LD50 orally in rats: 0.77 g/kg (Smyth)
Derivative Type: Lithium salt
CAS Registry Number: 4111-54-0
Additional Names: LDA; lithiodiisopropylamine; lithium diisopropylamide
Literature References: Strong nucleophile. Crystal structure: N. D. R. Barnett et al. J. Am. Chem. Soc.
113, 8187 (1991). Use as nucleophile: Y. Tanaka et al., Bull. Chem. Soc. Jpn.
60, 788 (1987); S. Saito et al., J. Am. Chem. Soc.
119, 611 (1997). Review of chemistry: Reagents for Organic Synthesis
vol. 8, M. Fieser, Ed. (Wiley-Interscience, New York, 1980) pp 292-299.
Properties: Powder, melts with decompn. Air and moisture sensitive.
CAUTION: Potential symptoms of overexposure are irritation of eyes, skin and respiratory system; nausea, vomiting; headache; visual disturbance. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 110.
Use: pH adjuster in colognes and toilet waters. In organic synthesis, particularly, the lithium salt.
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