其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Methisazone CAS Registry Number: 1910-68-5 美替沙腙

CAS Name: 2-(1,2-Dihydro-1-methyl-2-oxo-3H-indol-3-ylidene)hydrazinecarbothioamide
Additional Names: 1-methylindole-2,3-dione 3-thiosemicarbazone; N-methylisatin 3-thiosemicarbazoneTrademarks: ...
Literature References: Prepn: Bauer, Sadler, Br. J. Pharmacol. 15, 101 (1960); GB 975357 (1964 to Wellcome Found.).

Dihydroxyaluminum Acetylsalicylate CAS Registry Number: 53230-06-1

CAS Name: Dihydroxy(acetylsalicylato)aluminum
Additional Names: dihydroxyaluminum aspirin
Percent Composition: C 45.01%, H 3.78%, Al 11.24%, O 39.97%
Literature References: Prepn: Beekman, US 2698332 (1954 to Reheis); Schenck et al., US 2918485 (1959 to Keystone Chemurgic).

Sulfatolamide CAS Registry Number: 1161-88-2 磺胺托拉米

CAS Name: 4-Amino-N-(aminothioxomethyl)benzenesulfonamide compd with 4-(aminomethyl)benzenesulfonamide (1:1)
Additional Names: 1-sulfanilyl-2-thiourea compd with a-amino-p-toluenesulfonamide; a...
Literature References: Prepn: Behnisch, Klarer, US 2696454 (1954 to Schenley Ind.).

Hexachloroethane CAS Registry Number: 67-72-1 六氯乙烷

Additional Names: Carbon hexachloride; perchloroethane
Percent Composition: C 10.15%, Cl 89.85%
Literature References: Prepn: Beilstein 1, 87 (1918) and suppls. Toxicity data: Barsoum, Saad, Q. J. Pharm. Pharmacol. 7, 205 (1934). Review of toxicology and human exposure: Toxicological Profile for Hexachloroethane (PB98-101041, 1997) 190 pp.

Calcium Iodostearate CAS Registry Number: 1301-16-2

CAS Name: 2-Iodooctadecanoic acid calcium salt
Additional Names: stearodine
Percent Composition: C 50.35%, H 7.98%, Ca 4.67%, I 29.55%, O 7.45%
Literature References: Prepn: Beilstein vol. 2, 1st suppl., 177.

Calcium Iodobehenate CAS Registry Number: 1319-91-1

CAS Name: Iododocosanoic acid calcium salt
Trademarks: Calioben; Saiodin; Sajodin
Percent Composition: C 54.42%, H 8.72%, Ca 4.13%, I 26.14%, O 6.59%
Literature References: Prepn: Beilstein vol. 2, 392.

Phenacetin CAS Registry Number: 62-44-2 非那西丁

CAS Name: N-(4-Ethoxyphenyl)acetamide
Additional Names: p-acetophenetidide; p-ethoxyacetanilide; acetophenetidin; para-acetphenetidin; acet-p-phenetidin; p-acetophenetide
Percent Composition...
Literature References: Prepn: Beilstein vol. XIII, 461. Improved process: Eaker, Campbell, US 2887513 (1959 to Monsanto). Monograph: P. K. Smith, Acetophenetidin (Interscience, New York, 1958) 180 pp. Toxicity: Boyd, Toxicol. Appl. Pharmacol. 1, 240 (1959). Review of toxicity and metabolism studies: L. Fishbein, IARC Sci. Publ. 40, 287-310 (1981). Epidemiologic study of renal morbidity and mortality: U. C. Dubach et al., N. Engl. J. Med. 308, 357 (1983). Evaluation of renal effects: D. P. Sandler et al., ibid. 320, 1238 (1989).

Sodium Acid Pyrophosphate CAS Registry Number: 7758-16-9 焦磷酸二氢二钠

Additional Names: Disodium dihydrogen pyrophosphate
Percent Composition: H 0.91%, Na 20.72%, O 50.46%, P 27.91%
Literature References: Prepn: Bell, Inorg. Synth. 3, 98 (1950).

Amsonic Acid CAS Registry Number: 81-11-8 4,4'-二氨基二苯乙烯-2,2'-二磺酸

CAS Name: 2,2'-(1,2-Ethenediyl)bis[5-aminobenzenesulfonic acid]
Additional Names: 4,4'-diamino-2,2'-stilbenedisulfonic acid
Percent Composition: C 45.40%, H 3.81%, N 7.56%, O 25.92%, S 17.31...
Literature References: Prepn: Bender, Schultz, Ber. 19, 3234 (1886); H. E. Fierz-David, L. Blangey, Grundlegende Operationen der Farbenchemie (Springer-Verlag, Vienna, 7th ed., 1947) p 161; Spiegler, US 2784220 (1957 to du Pont).

Gliclazide CAS Registry Number: 21187-98-4 格列齐特

CAS Name: N-[[(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)amino]carbonyl]-4-methylbenzenesulfonamide
Additional Names: 1-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea; N-(4-methylb...
Literature References: Prepn: Beregi et al., FR 1510714 and US 3501495 (1968 and 1970, both to Sci. Union Co.-Soc. Franc. Rech. Med.). Series of articles on pharmacology: Arzneim.-Forsch. 22, 1686-1695 (1972). Toxicity data: J. Duhault et al., ibid. 1682. Review of pharmacology, efficacy: B. Holmes et al., Drugs 27, 301 (1984).