其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Cyclarbamate CAS Registry Number: 5779-54-4 环拉氨酯

CAS Name: 1,1-Cyclopentanedimethanol bis(phenylcarbamate)
Additional Names: 1,1-cyclopentanedimethanol dicarbanilate; cyclopentane-1,1-dimethanol bis(phenylcarbamate); 1,1-dihydroxymethylcyclop...
Literature References: Prepn: Bourdais, Bull. Soc. Chim. Fr. 1962, 266; E. Rosenberg, GB 904410 corresp to US 3067240 (both 1962 to Lab. Cassenne).

Thiethylperazine CAS Registry Number: 1420-55-9 乙巯匹拉嗪

CAS Name: 2-(Ethylthio)-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine
Additional Names: 3-ethylmercapto-10-(1'-methylpiperazinyl-4'-propyl)phenothiazine
Percent Composition: C 66.12%, H...
Literature References: Prepn: Bourquin et al., Helv. Chim. Acta 41, 1072 (1958).

Pyrilamine CAS Registry Number: 91-84-9 美吡拉敏

CAS Name: N-[(4-Methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl-1,2-ethanediamine
Additional Names: 2-[(2-dimethylaminoethyl)(p-methoxybenzyl)amino]pyridine; N-p-methoxybenzyl-N',N'-dimethyl...
Literature References: Prepn: Bovet et al., C.R. Seances Soc. Biol. Ses Fil. 138, 99 (1944); Huttrer et al., J. Am. Chem. Soc. 68, 1999 (1946); Viaud, Prod. Pharm. 2, 53 (1947); Horclois, US 2502151 (1950 to Rhône-Poulenc). Toxicity: A. von Schlichtergroll, Arzneim.-Forsch. 7, 237 (1957); of the maleate: F. Hunziker et al., ibid. 13, 324 (1963).

Butacetin CAS Registry Number: 2109-73-1 4-丁氧基乙酰胺

CAS Name: N-[4-(1,1-Dimethylethoxy)phenyl]acetamide
Additional Names: 4'-tert-butoxyacetanilide
Trademarks: Tromal (Burroughs Wellcome)
Percent Composition: C 69.54%, H 8.27%, N 6.76%, O ...
Literature References: Prepn: Bowden, Green, J. Chem. Soc. 1954, 1795.

Cloxyquin CAS Registry Number: 130-16-5 5-氯-8-羟基喹啉

CAS Name: 5-Chloro-8-quinolinol
Additional Names: 5-chloro-8-hydroxyquinoline; 5-chloro-8-oxychinolin; cloxiquine
Trademarks: Chlorisept (Chinosolfabrik)
Percent Composition: C 60.19%, H ...
Literature References: Prepn: Bratz, Niementowski, Ber. 52, 189 (1919); Weizmann, Bograchov, J. Am. Chem. Soc. 69, 1222 (1947); Manske et al., Can. J. Res. 27F, 359 (1949). Crystal structure: T. Banerjee, N. N. Saha, Acta Crystallogr. C42, 1408 (1986).

Sulfadimethoxine CAS Registry Number: 122-11-2 磺胺二甲氧嗪

CAS Name: 4-Amino-N-(2,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide
Additional Names: N1-(2,6-dimethoxy-4-pyrimidinyl)sulfanilamide; 2,6-dimethoxy-4-sulfanilamidopyrimidine; 2,4-dimethoxy-6-sul...
Literature References: Prepn: Bretschneider, Klötzer, US 2703800 (1955 to Oesterr. Stickstoffwerke); eidem, Monatsh. Chem. 87, 136 (1956); Langley, GB 866843 (1961 to I.C.I.); Bretschneider et al., Monatsh. Chem. 92, 128 (1961); US 3127398 (1964 to Hoffmann-La Roche); Shepherd et al., J. Org. Chem. 26, 2764 (1961). Toxicity data: Seki et al., Arzneim.-Forsch. 15, 1441 (1965). Toxicological, chemotherapeutic and pharmacokinetic studies: Böhni et al., Chemotherapy 14, 195-226 (1969); see also Aviado et al., ibid. 37.

Acetaminosalol CAS Registry Number: 118-57-0 醋氨沙洛

CAS Name: 2-Hydroxybenzoic acid 4-(acetylamino)phenyl ester
Additional Names: p-acetamidophenyl salicylate; acetylaminophenyl salicylate; acetyl-p-aminosalol; p-acetylaminophenol salicylic acid...
Literature References: Prepn: Brewster, J. Am. Chem. Soc. 40, 1136 (1918).

Butamben CAS Registry Number: 94-25-7 4-氨基苯甲酸丁酯

CAS Name: 4-Aminobenzoic acid butyl ester
Additional Names: butyl aminobenzoate; n-butyl p-aminobenzoate
Trademarks: Butesin (Abbott); Butoform; Planoform; Scuroforme
Percent Composition:...
Literature References: Prepn: Brill, J. Am. Chem. Soc. 43, 1322 (1921); Adams, Volwiler, US 1440652 (1923 to Abbott); GB 252870; C.A. 17, 1243 (1923); C.A. 21, 2478 (1927).

Diminazene Aceturate CAS Registry Number: 908-54-3 二乙酰胺三氮脒

CAS Name: N-Acetylglycine compd with 4,4'-(1-triazene-1,3-diyl)bis(benzenecarboximidamide) (2:1)
Additional Names: N-acetylglycine compd with 4,4'-(diazoamino)dibenzamidine; diminazene diacetur...
Literature References: Prepn: Brodersen et al., US 2838485 (1958 to Hoechst); Stavrovskaya, Drusvyatskaya, C.A. 59, 15199a (1963). Mode of action: Festy et al., C.R. Seances Acad. Sci. Ser. D 271, 730 (1970). Chemotherapeutic characteristics: Schmulevich et al., Veterinariya (Moscow) 38, 23 (1961), C.A. 56, 13512b (1962). Review: Newton in Antibiotics vol. 3, J. W. Corcoran, F. E. Hahn, Eds. (Springer-Verlag, New York, 1975) pp 34-47.

Alfadolone Acetate CAS Registry Number: 23930-37-2 3alpha,21-二羟基-5alpha-孕甾烷-11,20-二酮 21-乙酸酯

CAS Name: (3a,5a)-21-(Acetyloxy)-3-hydroxypregnane-11,20-dione
Additional Names: 3a,21-dihydroxy-5a-pregnane-11,20-dione 21-acetate; 21-acetoxy-3a-hydroxy-5a-pregnane-11,20-dione; alphadolone a...
Literature References: Prepn: Brown, Kirk, J. Chem. Soc. C 1969, 1653; Davis et al., DE 2030402 and ZA 7003861 (both 1971 to Glaxo), C.A. 75, 20793n, 64114w (1971).