其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Thiocresol CAS Registry Number: 26445-03-4

CAS Name: Methylbenzenethiol
Additional Names: methylthiophenol; tolylmercaptan; toluenethiol
Percent Composition: C 67.69%, H 6.49%, S 25.82%
Literature References: Prepn of m-isomer: D. S. Tarbell, D. K. Fukushima, Org. Synth. Coll. Vol. 3, 809 (1955).

Potassium Percarbonate CAS Registry Number: 589-97-9 过氧二碳酸,二钾盐

Percent Composition: C 12.12%, K 39.45%, O 48.43%
Literature References: Prepn of practically anhydr compd: Partington, Fathallah, J. Chem. Soc. 1950, 1934.

N-Acetylmethionine CAS Registry Number: 65-82-7 N-乙酰-L-蛋氨酸

Percent Composition: C 43.96%, H 6.85%, N 7.32%, O 25.10%, S 16.77%
Literature References: Prepn of racemic mixture: Wheeler, Ingersoll, J. Am. Chem. Soc. 73, 4604 (1951); Callanan, Patton, US 2745873 (1956 to Distillers Products). Resolution: Wheeler, Ingersoll, loc. cit.; Gillingham, US 3028395 (1962 to Parke, Davis); Tullar, US 3056799 (1962 to Sterling Drug); GB 1072876 (1967 to Tanabe Seiyaku), C.A. 67, 114015x (1967).

Furtrethonium CAS Registry Number: 7618-86-2

CAS Name: N,N,N-Trimethyl-2-furanmethanaminium
Additional Names: furfuryltrimethylammonium; trimethylfurfurylammonium; furtrimethonium
Trademarks: Furmethide (SK F)
Literature References: Prepn of salts: Nabenhauer, US 2185220 (1938 to SK F); Weilmuenster, Jordan, J. Am. Chem. Soc. 67, 415 (1945); Khromov-Borisov et al., J. Gen. Chem. USSR 24, 2021 (1954).

Fluazacort CAS Registry Number: 19888-56-3 氟扎可特

CAS Name: (11b,16b)-21-(Acetyloxy)-9-fluoro-11-hydroxy-2'-methyl-5'H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione
Additional Names: 9-fluoro-11b,21-dihydroxy-2'-methyl-5'bH-pregna-1,4-dieno[17,1...
Literature References: Prepn of the 21-hydroxy compound: G. Nathansohn et al., J. Med. Chem. 10, 799 (1967); of the 21-hydroxy and fluazacort: eidem, GB 1119082; eidem, US 3461119 (1968, 1969 to Lepetit); eidem, Steroids 13, 383 (1969). Pharmacological and physico-chemical properties: eidem, ibid. 365. Percutaneous absorption: J. D. Lewis et al., Arzneim.-Forsch. 25, 1646 (1975).

b -Benzalbutyramide CAS Registry Number: 7236-47-7 3-苯亚甲基丁酰胺

CAS Name: 3-Methyl-4-phenyl-3-butenamide
Additional Names: 3-methyl-4-phenyl-3-butenoic acid amide; b-benzylidenebutyramide
Trademarks: Kata-Lipid (IBI)
Percent Composition: C 75.40%, H 7...
Literature References: Prepn of the acid: Canonica et al., Farmaco Ed. Sci. 14, 112 (1959); Datta, Bagchi, J. Org. Chem. 25, 932 (1960). Clinical studies in atherosclerotic patients: F. Del Regno, G. Capobianco, Minerva Med. 54, 2917 (1963); A. Iacobelli et al., G. Arterioscler. 4, 277 (1966); M. G. Piccardo et al., ibid. 294. Metabolism: L. Canonica et al., J. Biol. Chem. 243, 1645 (1968). Inhibition of cholesterol biosynthesis: D. Giorgini, G. Porcellati, Farmaco Ed. Sci. 24, 392 (1969). Clinical evaluation in hyperlipidemia: U. Marini et al., Farmaco Ed. Prat. 36, 532 (1981).

Diatrizoate Sodium CAS Registry Number: 737-31-5 泛影酸钠

CAS Name: 3,5-Bis(acetylamino)-2,4,6-triiodobenzoic acid sodium salt
Additional Names: 3,5-diacetamido-2,4,6-triiodobenzoic acid sodium salt; sodium 3,5-diacetamido-2,4,6-triiodobenzoate; urogr...
Literature References: Prepn of the acid: Larsen et al., J. Am. Chem. Soc. 78, 3210 (1956). Description: Langecker et al., Arch. Exp. Pathol. Pharmakol. 222, 584 (1954). Use in separation of leukocytes from whole blood: R. J. Perper et al., J. Lab. Clin. Med. 72, 842 (1968); L. P. Bignold, A. Ferrante, J. Immunol. Methods 96, 29 (1987); J. R. Kalmar et al., ibid. 110, 275 (1988). Comprehensive description: H. H. Lerner, Anal. Profiles Drug Subs. 4, 137-167 (1975).

Bornyl Acetate CAS Registry Number: 76-49-3 乙酸龙脑酯

CAS Name: 1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol acetate
Additional Names: borneol acetate
Percent Composition: C 73.43%, H 10.27%, O 16.30%
Literature References: Prepn of the d-form by acylation of d-borneol: Shishido et al., J. Am. Chem. Soc. 82, 125 (1960).

Pipamperone CAS Registry Number: 1893-33-0 匹泮哌隆

CAS Name: 1'-[4-(4-Fluorophenyl)-4-oxobutyl]-[1,4'-bipiperidine]-4'-carboxamide
Additional Names: 1'-[3-(p-fluorobenzoyl)propyl]-[1,4'-bipiperidine]-4'-carboxamide; 1-(p-fluorophenyl)-4-(4-pipe...
Literature References: Prepn of the dihydrochloride by reaction of g-chloro-4-fluorobutyrophenone and 4-piperidinopiperidine-4-carboxamide: Janssen, BE 610830 (1962 to Janssen), C.A. 57, 13740b (1962).

Eprazinone CAS Registry Number: 10402-90-1 盐酸依普拉酮

CAS Name: 3-[4-(2-Ethoxy-2-phenylethyl)-1-piperazinyl]-2-methyl-1-phenyl-1-propanone
Additional Names: 3-[4-(b-ethoxyphenethyl)-1-piperazinyl]-2-methylpropiophenone
Percent Composition: C 75...
Literature References: Prepn of the dihydrochloride: R. Y. Mauvernay, NL 6602581; idem, US 3448192 (1966, 1969 both to Riom). Pharmacodynamics: J. Vacher et al., Arch. Int. Pharmacodyn. Ther. 165, 1 (1967). Pharmacological study: Y. Kase et al., Nippon Yakurigaku Zasshi 73, 605 (1977), C.A. 88, 15657 (1978). Efficacy: W. Spitzer, Fortschr. Med. 98, 871 (1980). Metabolism: P. Toffel-Nadolny, W. Gielsdorf, Arzneim.-Forsch. 31, 719 (1981).