其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

a -Aminobutyric Acid CAS Registry Number: 80-60-4 2-氨基丁酸

CAS Name: 2-Aminobutanoic acid
Additional Names: a-amino-n-butyric acid
Percent Composition: C 46.59%, H 8.80%, N 13.58%, O 31.03%
Literature References: Prepn of the DL-form from a-bromobutyric acid and ammonia: Fisher, Mounegrat, Ber. 33, 2388 (1900); from potassium cyanide, ammonium chloride and propionaldehyde: Zelinsky, Stadnikow, Ber. 41, 2062 (1908); by reduction of a-oxobutyric acid: Knoop, Oesterlin, Z. Physiol. Chem. 148, 305 (1925); from a-ethylacetoacetic ester and hydrazoic acid: Schmidt, Ber. 57, 706 (1924). The L(+)-form has been isolated from proteins: Oikawa, Chem. Zentralbl. 1926, 1, 148. Configuration: Clough, J. Chem. Soc. 113, 544, 551; Levene, Chem. Rev. 2, 203 (1926); Vogler, Helv. Chim. Acta 30, 1766 (1947).

a -( a -Aminopropyl)benzyl Alcohol CAS Registry Number: 5897-76-7 alpha-(alpha-氨基丙基)苄醇

CAS Name: a-(1-Aminopropyl)benzenemethanol
Additional Names: 2-amino-1-phenyl-1-butanol; b-amino-a-phenylbutyl alcohol; 1-phenyl-1-hydroxy-2-amino-n-butane
Percent Composition: C 72.69%, H 9...
Literature References: Prepn of the dl-threo-form: Abrams, Kipping, J. Chem. Soc. 1936, 1480; Rebstock et al., J. Am. Chem. Soc. 73, 3666 (1951). Prepn of the dl-erythro-form: Hartung et al., ibid. 52, 3317 (1930); Rebstock et al., loc. cit. See also Beilstein 13, suppl. 3, 1791-1792 (1973).

Antimony Sodium Thioglycollate CAS Registry Number: 539-54-8

CAS Name: [(5-Oxo-1,3,2-oxathiostibolan-2-yl)thio]acetic acid sodium salt
Additional Names: mercaptoacetic acid antimony derivative sodium salt; antimony sodium thioacetate
Percent Compositi...
Literature References: Prepn of the free acid: Klason, Carlson, Ber. 39, 732 (1906); of the salt: Myers, J. Lab. Clin. Med. 6, 359 (1921).

Proparacaine CAS Registry Number: 499-67-2 丙美卡因

CAS Name: 3-Amino-4-propoxybenzoic acid 2-(diethylamino)ethyl ester
Additional Names: 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate; proxymetacaine
Percent Composition: C 65.28%, H 8.90%, ...
Literature References: Prepn of the hydrochloride: Clinton et al., J. Am. Chem. Soc. 74, 592 (1952). Pharmacology: McIntyre, Sievers, J. Pharmacol. Exp. Ther. 63, 369 (1938). Comprehensive description: D. B. Whigan, Anal. Profiles Drug Subs. 6, 423-456 (1977).

Butethamine CAS Registry Number: 2090-89-3 丁胺卡因

CAS Name: 2-[(2-Methylpropyl)amino]ethanol 4-aminobenzoate (ester)
Additional Names: 2-(isobutylamino)ethanol p-aminobenzoate (ester); 2-(isobutylamino)ethyl p-aminobenzoate
Percent Composit...
Literature References: Prepn of the hydrochloride: Goldberg, US 2139818 (1938 to Novocol Chem.); J. Büchi et al., Arzneim.-Forsch. 14, 161 (1964); 16, 1657 (1966).

Piperocaine CAS Registry Number: 136-82-3 哌罗卡因

CAS Name: 2-Methyl-1-piperidinepropanol benzoate
Additional Names: g-(2-methylpiperidyl)propyl benzoate; (2-methylpiperidino)propyl benzoate; 3-benzoxy-1-(2-methylpiperidino)propane; benzoyl-g-...
Literature References: Prepn of the hydrochloride: S. M. McElvain, US 1784903 (1930). Pharmacology: K. H. Beyer, A. R. Latven, J. Pharmacol. Exp. Ther. 106, 37 (1952). Structure activity study: P. P. Koelzer, K. H. Wehr, Arzneim.-Forsch. 8, 708 (1958).

Halofantrine CAS Registry Number: 69756-53-2 卤方特瑞

CAS Name: 1,3-Dichloro-a-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-9-phenanthrenemethanol
Additional Names: 1-(1,3-dichloro-6-trifluoromethyl-9-phenanthryl)-3-di(n-butyl)aminopropanol; g-(dib...
Literature References: Prepn of the hydrochloride: W. T. Colwell et al., J. Med. Chem. 15, 771 (1972); of the b-glycerophosphate salt: J. F. Rossignol, EP 138374; idem, US 4507288 (both 1985 to Smithkline Beckman). Antimalarial activity in vivo: L. H. Schmidt et al., Antimicrob. Agents Chemother. 14, 292 (1978). HPLC determn in human blood: J. W. Hines et al., J. Pharm. Sci. 74, 433 (1985). Antimalarial activity in clinically-induced infection in humans: J. Rinehart et al., Am. J. Trop. Med. Hyg. 25, 769 (1976); T. M. Cosgriff et al., ibid. 31, 1075 (1982); in naturally acquired disease: J. P. Coulaud et al., Trans. R. Soc. Trop. Med. Hyg. 80, 615 (1986). Review of pharmacology and therapeutic potential: H. M. Bryson, K. L. Goa, Drugs 43, 236-258 (1992).

Sulthiame CAS Registry Number: 61-56-3 噻嗪磺胺

CAS Name: 4-(Tetrahydro-2H-1,2-thiazin-2-yl)benzenesulfonamide S,S-dioxide
Additional Names: N-(4'-sulfamylphenyl)-1,4-butanesultam; tetrahydro-2-(p-sulfamoylphenyl)-1,2-thiazine 1,1-dioxide; 2...
Literature References: Prepn of this type of compd: Helferich, Behnisch, US 2916489 (1959 to Schenley).

Gold Tricyanide CAS Registry Number: 535-37-5 三氰化金

Additional Names: Auric cyanide
Percent Composition: C 13.10%, Au 71.62%, N 15.28%
Literature References: Prepn of trihydrate: Chadwick, Sharpe, Adv. Inorg. Chem. Radiochem. 8, 157-158 (1966).

Antimony Potassium Oxalate CAS Registry Number: 5965-33-3

CAS Name: Ethanedioic acid anhydride with antimonic acid (3:1) tripotassium salt
Additional Names: tripotassium tris(oxalato)antimonate(3-); potassium oxalatoantimonate(III); antimony salt
P...
Literature References: Prepn of trihydrate: Graddon, J. Inorg. Nucl. Chem. 3, 308 (1956-1957).