其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Macromerine CAS Registry Number: 2970-95-8 1-(3,4-二甲氧基苯基)-2-二甲基氨基乙醇

CAS Name: a-[(Dimethylamino)methyl]-3,4-dimethoxybenzenemethanol
Additional Names: a-[(dimethylamino)methyl]veratryl alcohol; 3,4-dimethoxy-a-[(dimethylamino)methyl]benzyl alcohol; dimethylamin...
Literature References: Prepn of dl-form: La Manna et al., Farmaco Ed. Sci. 15, 9 (1960); Chapman et al., Proc. R. Soc. London Ser. B 163, (990), 116 (1965); Hodgkins et al., Tetrahedron Lett. 1967, 1321; of d- and l-forms: La Manna et al., loc. cit. Isoln of l-form from cactus, Coryphantha macromeris (Engelm.) Lem., Britton and Rose, Cactaceae: Hodgkins et al., loc. cit.

a -Bromoisovaleric Acid CAS Registry Number: 565-74-2 2-溴-3-甲基丁酸

CAS Name: 2-Bromo-3-methylbutanoic acid
Percent Composition: C 33.17%, H 5.01%, Br 44.14%, O 17.68%
Literature References: Prepn of dl-form: Ley, Popow, Ann. 174, 61 (1874); Smissman, J. Am. Chem. Soc. 76, 5805 (1954); Marvel, Org. Synth. coll. vol. III, 848 (1955). Prepn of d- and l-forms: Berlingozzi, Furia, Gazz. Chim. Ital. 56, 82 (1926); Berlingozzi, Lenoci, ibid. 68, 721 (1938). Configuration of d-form: Brewster et al., Nature 166, 179 (1950).

Dioxadrol CAS Registry Number: 6495-46-1 二苯恶啶

CAS Name: 2-(2,2-Diphenyl-1,3-dioxolan-4-yl)piperidine
Additional Names: 2,2-diphenyl-4-(2-piperidyl)-1,3-dioxolane
Percent Composition: C 77.64%, H 7.49%, N 4.53%, O 10.34%
Literature References: Prepn of dl-forms and resolution of a-racemates: Hardie, Halverstadt, BE 613262; US 3262938 (1962, 1966 both to Cutter Labs.); W. R. Hardie et al., J. Med. Chem. 9, 127 (1966).

Doxycycline CAS Registry Number: 17086-28-1 (monohydrate); 564-25-0 (anhydrous) 强力霉素一水物

CAS Name: [4S-(4a,4aa,5a,5aa,6a,12aa)]-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrate
Additional Names: a-6...
Literature References: Prepn of family of 6-deoxytetracyclines: C. R. Stephens et al., J. Am. Chem. Soc. 80, 5324 (1958). See also: McCormick, Jensen, US 3019260 (1962 to Am. Cyanamid). Prepn, separation and configuration of 6a- and 6b-epimers: M. S. von Wittenau et al., J. Am. Chem. Soc. 84, 2645 (1962); C. R. Stephens et al., ibid. 85, 2643 (1963). Prepn of 6a-deoxyoxytetracycline: R. K. Blackwood et al., US 3200149 (1965 to Pfizer). 1H-NMR study: M. S. von Wittenau, R. K. Blackwood, J. Org. Chem. 31, 613 (1966). Biological properties: English, Proc. Soc. Exp. Biol. Med. 122, 1107 (1966). Pharmacology: Fabre, Chemotherapia 11, 73 (1966); Gibaldi, ibid. 12, 265 (1967). Toxicity of hyclate: Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971). Clinical trial in prophylaxis of leptospirosis: E. T. Takafuji et al., N. Engl. J. Med. 310, 497 (1984). Clinical trial in periodontitis: A. M. Polson et al., J. Periodontol. 68, 110, 119 (1997). Review: C. Edwards in Pharmacological and Biochemical Properties of Drug Substances vol. 2, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1979) pp 305-332.

Arsacetin CAS Registry Number: 618-22-4 4-乙酰氨基苯基砷酸

CAS Name: [4-(Acetylamino)phenyl]arsonic acid
Additional Names: p-acetamidobenzenearsonic acid; N-acetyl-p-aminobenzenearsonic acid; N-acetylarsanilic acid
Percent Composition: C 37.09%, H 3...
Literature References: Prepn of free acid and sodium salt: Bart, Ann. 429, 55 (1922). Toxicity: A. Gros, Biochem. Z. 184, 360 (1927).

Cyproterone CAS Registry Number: 2098-66-0 环丙孕酮

CAS Name: (1b,2b)-6-Chloro-1,2-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione
Additional Names: 6-chloro-17-hydroxy-1a,2a-methylenepregna-4,6-diene-3,20-dione; 6-chloro-6-...
Literature References: Prepn of free alcohol: Wiechert, Neumann, DE 1189991 C.A. 63, 1842e (1965); Wiechert, US 3234093 (1965, 1966 both to Schering AG). Biodynamics in man: Gerhards et al., Arzneim.-Forsch. 23, 1550 (1973). The free alcohol is an anti-androgen; the acetate is both an anti-androgen and a progestogen. Effect on hormone secretion and on spermatogenesis in man: L. Moltz et al., Contraception 21, 393 (1980). Review of pharmacology and clinical studies (acetate) on acne and hirsutism in women: J. Hammerstein et al., J. Steroid Biochem. 19, 591 (1983).

Aluminum Antimonide CAS Registry Number: 25152-52-7 硫酸铵铝

Percent Composition: Al 18.14%, Sb 81.86%
Literature References: Prepn of high purity crystals, resistance measurements, activation energies: Justi, Lautz, Abh. Braunschw. Wiss. Ges. 5, 36 (1953); C.A. 48, 1756i (1954). Electrical properties: Willardson et al., J. Electrochem. Soc. 101, 354 (1954); and prepn: Kover, Compt. Rend. 243, 648 (1956). Zone melting to remove impurities and to improve electr properties: Scheel, Z. Metallkd. 46, 58 (1955), C.A. 49, 4486f (1955). Oxidation by water: Rudorff, Kohlmeyer, Z. Metallkd. 45, 608 (1954), C.A. 49, 7432c (1955).

Moxaverine CAS Registry Number: 10539-19-2 莫沙维林

CAS Name: 3-Ethyl-6,7-dimethoxy-1-(phenylmethyl)isoquinoline
Additional Names: 1-benzyl-3-ethyl-6,7-dimethoxyisoquinoline
Percent Composition: C 78.15%, H 6.89%, N 4.56%, O 10.41%
Literature References: Prepn of hydrochloride: FR 1362765 (1964 to Orgamol, SA), C.A. 62, 536f (1965). Physical properties and solution stability: E. Pawelczyk, M. Zajac, Diss. Pharm. Pharmacol. 24, 5 (1972). HPLC determn in pharmaceutical formulations: E. H. Girgis, J. Pharm. Sci. 82, 503 (1993).

Fipexide CAS Registry Number: 34161-24-5 非哌西特盐酸盐

CAS Name: 1-(1,3-Benzodioxol-5-ylmethyl)-4-[(4-chlorophenoxy)acetyl]piperazine
Additional Names: 1-[(p-chlorophenoxy)acetyl]-4-piperonylpiperazine; 1-[2-(4-chlorophenoxy)acetyl]-4-(3,4-methylen...
Literature References: Prepn of hydrochloride: A. Buzas, R. Pierre, FR M7524 (1970 to Lab Bouchard), C.A. 75, 112865r (1971). Manufacturing process: G. P. Gardini et al., US 4225714 (1980 to Farmaceutici Geymon.). Improved prepn: G. P. Gardini et al., Synth. Commun. 12, 887 (1982). Determn by TLC: G. Musumarra et al., J. Chromatogr. 350, 151 (1985). Toxicology and pharmacology: G. David et al., Acta Ther. 11, 387 (1985). Clinical trial in the elderly: B. Bompani, G. Scali, Curr. Med. Res. Opin. 10, 99 (1986).

Oxypinocamphone CAS Registry Number: 10136-65-9 2-羟基-2,6,6-三甲基双环[3.1.1]庚烷-3-酮

CAS Name: 2-Hydroxy-2,6,6-trimethylbicyclo[3.1.1]heptan-3-one
Additional Names: 2-hydroxy-3-pinanone; 2-hydroxypinocamphone
Trademarks: Camphostene; Oxypinone
Percent Composition: C 71.39...
Literature References: Prepn of l-form: Kuwata, J. Am. Chem. Soc. 59, 2509 (1937); Harispe et al., Bull. Soc. Chim. Fr. 1964, 1035; of dl-form: Kuwata, loc. cit. Stereochemistry: Carlson et al., Tetrahedron Lett. 1968, 5941.