其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

a -Phenylcinnamic Acid CAS Registry Number: 3368-16-9 Alpha-苯基-顺-肉桂酸

CAS Name: a-(Phenylmethylene)benzeneacetic acid
Additional Names: 2,3-diphenylacrylic acid; 2,3-diphenylpropenoic acid; stilbene-a-carboxylic acid
Percent Composition: C 80.34%, H 5.39%, O 1...
Literature References: Prepn of cis-form: Buckles, Hausman, J. Am. Chem. Soc. 70, 415 (1948); Buckles, J. Chem. Educ. 27, 210 (1950); Buckles, Bremer, Org. Synth. coll. vol. IV, 777 (1963); B. H. Patwardhan, G. Bagavant, Indian J. Chem. 10, 59 (1972). Prepn of cis- and trans-forms: L. F. Fieser, Experiments in Organic Chemistry (Heath, Boston, 3rd ed., 1955) p 182. Isomerization studies: S. V. Kessar et al., Indian J. Chem. 20B, 4 (1981).

Furfurylmethylamphetamine CAS Registry Number: 13445-60-8 2-呋喃甲基,N-甲基-N-(1-甲基-2-苯乙基)-

CAS Name: N-Methyl-N-(1-methyl-2-phenylethyl)-2-furanmethanamine
Additional Names: N-methyl-N-(a-methylphenethyl)furfurylamine; N-methyl-N-(1-phenyl-2-propyl)furfurylamine
Trademarks: Furfen...
Literature References: Prepn of d- and dl-forms: Boissier, Ratouis, FR M3332 and FR 1407075 (both 1965 to S.I.F.A.), C.A. 63, 13214g, 13215c (1965).

Hydrobenzoin CAS Registry Number: 492-70-6 1,2-二苯乙烷-1,2-二醇

CAS Name: 1,2-Diphenyl-1,2-ethanediol
Additional Names: diphenylethyleneglycol
Percent Composition: C 78.48%, H 6.59%, O 14.93%
Literature References: Prepn of d-, l-, dl- and meso-forms: Forst, Zincke, Ann. 182, 262, 275 (1876); Irvine, Weir, J. Chem. Soc. 91, 1390 (1907); Buck, Jenkins, J. Am. Chem. Soc. 51, 2163 (1929); L. F. Fieser, Organic Experiments (D. C. Heath, Boston, 1964) pp 210, 214, 216-217, 229-231. Improved method for prepn of dl-form from the meso isomer: Collet, Synthesis 1973, 664.

Alcuronium CAS Registry Number: 23214-96-2

CAS Name: 4,4'-Didemethyl-4,4'-di-2-propenyltoxiferine I
Additional Names: N,N'-diallylnortoxiferinium; diallylbis(nortoxiferine); diallylnortoxiferine; diallyltoxiferine
Literature References: Prepn of dichloride and diiodide: Boller et al., US 3080373 (1963 to Hoffmann-La Roche).

Idose CAS Registry Number: 2152-76-3

Percent Composition: C 40.00%, H 6.71%, O 53.28%
Literature References: Prepn of D-idose by reduction of D-idonolactone: Fischer, Fay, Ber. 28, 1975 (1895); from D-galactose: Sorking, Reichstein, Helv. Chim. Acta 28, 1 (1945); from tri-O-acetyl-1,6-anhydro-b-D-idopyranose: eidem, ibid. 662. Prepn of L-idose by reduction of L-idonolactone: Fischer, Fay, loc. cit.; by hydrolysis of 1,2-O-isopropylidene-L-idofuranose: Meyer, Reichstein, Helv. Chim. Acta 29, 152 (1946); von Vargha, Ber. 87, 1351 (1954). Improved synthesis: M. Blanc-Muesser, J. Defaye, Synthesis 1977, 568. Structure: S. F. Dyke, The Carbohydrates (Interscience, New York, 1960) p 45. Conformation: Reeves, J. Am. Chem. Soc. 72, 1499 (1950). Review: R. L. Whistler, M. L. Wolfrom, Methods in Carbohydrate Chemistry (Academic Press, New York, 1962) pp 140-145.

Gold Sodium Thiosulfate CAS Registry Number: 15283-45-1 硫代硫酸金(I)钠水合物

CAS Name: Trisodium (T-4)-bis[monothiosulfato(2-)-kO,kS]-aurate(3-)
Additional Names: hyposulfite of gold and sodium; sodium aurothiosulfate
Trademarks: Aurocidin; Aurolin (UCB); Crisalbine;...
Literature References: Prepn of dihydrate: Fordos, Gélis, Ann. Chim. Phys. 13, 394 (1845); H. Brown, J. Am. Chem. Soc. 49, 958 (1927); Roger's Inorganic Pharmaceutical Chemistry, T. O. Soine, C. O. Wilson, Eds. (Lea Febiger, Philadelphia, 8th ed., 1967) pp 343-345. Crystal structure of dihydrate: H. Ruben et al., Inorg. Chem. 13, 1836 (1974). Efficacy of antidotes: M. A. Basinger et al., J. Rheumatol. 12, 274 (1985). Clinical study of contact allergy patch test reactions: K. E. McKenna et al., Contact Dermatitis 32, 143 (1995). Clinical evaluation in rheumatoid arthritis: M. L. Ciompi et al., Reumatismo 54, 251 (2002).

Bromosuccinic Acid CAS Registry Number: 923-06-8 溴代丁二酸

CAS Name: Bromobutanedioic acid
Additional Names: monobromosuccinic acid
Percent Composition: C 24.39%, H 2.56%, Br 40.56%, O 32.49%
Literature References: Prepn of dl-form by bromination of succinic acid: Kekulé, Ann. 117, 120 (1861); from fumaric acid and HBr: Fittig, Ann. 188, 42 (1877); by bromination of succinyl bromide or succinic anhydride: Hughes, Watson, J. Chem. Soc. 1930, 1733. Prepn of l-form from l-aspartic acid: Walden, Ber. 29, 133 (1896); Karrer et al., Helv. Chim. Acta 30, 271 (1947).

sec-Butyl Iodide CAS Registry Number: 513-48-4 碘代仲丁烷

CAS Name: 2-Iodobutane
Percent Composition: C 26.11%, H 4.93%, I 68.96%
Literature References: Prepn of dl-form from 2-butanol: Kornblum et al., J. Am. Chem. Soc. 77, 5528 (1955); from dibutyl ether: Long, Freeguard, Chem. Ind. (London) 1965, 223. Prepn of d-form from l-butanol: Kenyon et al., J. Chem. Soc. 1935, 1072. Prepn of l-form from d-2-butanol: Levene, Rothen, J. Biol. Chem. 115, 415 (1936); Kornblum et al., J. Am. Chem. Soc. 70, 746 (1948).

Pheniprazine CAS Registry Number: 55-52-7 苯异丙肼

CAS Name: (1-Methyl-2-phenylethyl)hydrazine
Additional Names: (a-methylphenethyl)hydrazine; (1-benzylethyl)hydrazine; 1-phenyl-2-hydrazinopropane; b-phenylisopropylhydrazine; PIH
Percent Com...
Literature References: Prepn of DL-form: Biel et al., J. Am. Chem. Soc. 80, 1519 (1958); 81, 2805 (1959); Biel, US 2978461 and US 3000903 (both to Lakeside). Resolution of stereoisomers: Bernstein et al., J. Am. Chem. Soc. 81, 4433 (1959). Synthesis: Biel et al., ibid. 4995.

Etoxadrol CAS Registry Number: 28189-85-7 乙苯噁啶

CAS Name: (2S)-2-[(2S,4S)]-2-(2-Ethyl-2-phenyl-1,3-dioxolan-4-yl)piperidine
Additional Names: (+)-2-(2-Ethyl-2-phenyl-1,3-dioxolan-4-yl)piperidine; 2-ethyl-2-phenyl-4-(2-piperidyl)-1,3-dioxolan...
Literature References: Prepn of dl-form: Hardie et al., J. Med. Chem. 9, 127 (1966); Hardie, Halverstadt, US 3262938 (1966 to Cutter Labs). Resolution of the a-racemates: Allen et al., DE 2001616 (1970 to Cutter Labs), C.A. 74, 13129b (1971). Pharmacological studies: Traber et al., J. Pharmacol. Exp. Ther. 175, 395 (1970); Hidalgo et al., Anesth. Analg. 50, 231 (1971); Kelly et al., ibid. 262.