其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

N-Chlorosuccinimide CAS Registry Number: 128-09-6 N-氯代丁二酰亚胺

CAS Name: 1-Chloro-2,5-pyrrolidinedione
Additional Names: succinchlorimide
Percent Composition: C 35.98%, H 3.02%, Cl 26.55%, N 10.49%, O 23.96%
Literature References: Prepn from succinimide: Hirst, Macbeth, J. Chem. Soc. 121, 2169 (1922); Zimmer, Audrieth, J. Am. Chem. Soc. 76, 3856 (1954). Crystal structure: Brown, Acta Crystallogr. 9, 193 (1956); 14, 711 (1961). Toxicity data: Stohlman, Smith, Public Health Rep. 59, 541 (1944).

Sucrose Octaacetate CAS Registry Number: 126-14-7 蔗糖八乙酸酯

Percent Composition: C 49.56%, H 5.64%, O 44.80%
Literature References: Prepn from sucrose: Linstead et al., J. Am. Chem. Soc. 62, 3260 (1940). Synthesis: Lemieux, Huber, ibid. 78, 4117 (1956).

Trichloroethylene CAS Registry Number: 79-01-6 三氯乙烯

CAS Name: Trichloroethene
Additional Names: ethinyl trichloride
Trademarks: Tri-Clene (DuPont); Trilene (Zeneca); Trichloren; Algylen; Trimar; Triline; Trethylene; Westrosol; Chlorylen (Sche...
Literature References: Prepn from sym-tetrachloroethane by elimination of HCl (by boiling with lime): DE 171900; by passing tetrachloroethane vapor over CaCl2 catalyst at 300°: DE 263457; without catalyst at 450-470°: GB 575530 (1946 to du Pont). Physical properties: E. W. McGovern, Ind. Eng. Chem. 35, 1230 (1943); S. A. Mumford, J. W. C. Phillips, J. Chem. Soc. 1950, 75. Review of mfg processes: S. A. Miller, Chem. Process Eng. 47, 268 (1966); Faith, Keyes Clark's Industrial Chemicals, F. A. Lowenheim, M. K. Moran, Eds. (Wiley-Interscience, New York, 4th ed., 1975) pp 844-848. Toxicity data: H. S. Smyth et al., Am. Ind. Hyg. Assoc. J. 30, 470 (1969). Review of carcinogenic risk: IARC Monographs 20, 545-572 (1979); B. L. Van Duuren, Environ. Res. 49, 333 (1989). Review of use as anesthetic: J. V. Farman, Br. J. Anaesth. 53, Suppl. 3, 3S-9S (1981). Review of metabolism, toxicity and carcinogenicity: J. V. Bruckner et al., Crit. Rev. Toxicol. 20, 31-50 (1989); of toxicology and human exposure: Toxicological Profile for Trichloroethylene (PB98-101165, 1997) 335 pp. Series of articles on toxicology and risk assessment: Environ. Health Perspect. 108, Suppl. 2, 159-366 (2000).

Dihydroxymaleic Acid CAS Registry Number: 526-84-1 二羟基顺丁烯二酸

CAS Name: (Z)-2,3-Dihydroxy-2-butenedioic acid
Additional Names: 1,2-dihydroxyethylenedicarboxylic acid
Percent Composition: C 32.45%, H 2.72%, O 64.83%
Literature References: Prepn from tartaric acid: Fenton, J. Chem. Soc. 87, 811 (1905); Nef, Ann. 357, 291 (1907).

Trinitromethane CAS Registry Number: 517-25-9 三硝基甲烷

Additional Names: Nitroform
Percent Composition: C 7.95%, H 0.67%, N 27.82%, O 63.56%
Literature References: Prepn from tetranitromethane and K4[Fe(CN)6] in aq soln: Chattaway, Harrison, J. Chem. Soc. 109, 171 (1916); by nitration of acetylene with nitric acid: Hager, Ind. Eng. Chem. 41, 2168 (1949).

Diphenylamine-2,2 ¢ -dicarboxylic Acid CAS Registry Number: 579-92-0 2,2'-氮杂二基二苯甲酸

CAS Name: 2,2'-Iminobis[benzoic acid]
Percent Composition: C 65.37%, H 4.31%, N 5.44%, O 24.88%
Literature References: Prepn from the alkali salts of anthranilic acid and of 2-chlorobenzoic acid in presence of copper: Ullmann, Ann. 355, 352 (1907).

Allenolic Acid CAS Registry Number: 553-39-9 6-羟基-2-萘丙酸

CAS Name: 6-Hydroxy-2-naphthalenepropanoic acid
Additional Names: 2-hydroxy-6-naphthalenepropionic acid; amphihydroxynaphthyl-b-propionic acid
Percent Composition: C 72.21%, H 5.59%, O 22.20...
Literature References: Prepn from the corresponding methoxy compd: Jacques, Horeau, Bull. Soc. Chim. Fr. 1948, 714.

Thebainone CAS Registry Number: 467-98-1 蒂巴因酮

CAS Name: 7,8-Didehydro-4-hydroxy-3-methoxy-17-methylmorphinan-6-one
Additional Names: thebainone-A
Percent Composition: C 72.22%, H 7.07%, N 4.68%, O 16.03%
Literature References: Prepn from thebaine, codeinone or b-ethylthiocodide: Morris, Small, J. Am. Chem. Soc. 56, 2159 (1934). Earlier references and discussion of structure: Small, Lutz, "Chemistry of the Opium Alkaloids" in U.S. Public Health Reports Suppl. No. 103 (Washington, 1932). About anomalies in nomenclature and difference from metathebainone see Henry, Plant Alkaloids (London, 1939) p 249. Description of all thebainones: K. W. Bentley, The Chemistry of the Morphine Alkaloids (Oxford, 1954) p 219.

Pentifylline CAS Registry Number: 1028-33-7 1-己基-3,7-二甲基-1H-嘌呤-2,6(3H,7H)-二酮

CAS Name: 1-Hexyl-3,7-dihydro-3,7-dimethyl-1H-purine-2,6-dione
Additional Names: 1-hexyltheobromine; 1-hexyl-3,7-dimethylxanthine; 3,7-dimethyl-1-hexyl-1H,3H-purin-2,6-dioneTrademarks: Cosaldon...
Literature References: Prepn from theobromine and hexyl halide: Eidebenz, Schuh, DE 860217 (1952 to Chem. Werke Albert); Serchi, Chimica 40, 451 (1964); Chkhikvadze et al., SU 202152 (1967), C.A. 69, 19368x (1968). Pharmacology: Cugurra, Echinard-Garin, Arch. Int. Pharmacodyn. Ther. 123, 481 (1960); Ramos et al., ibid. 153, 430 (1965); Mohler et al., Arzneim.-Forsch. 16, 1524 (1966). Metabolic studies: Mohler et al., Arch. Pharm. 299, 448 (1966).

Dimethazan CAS Registry Number: 519-30-2 二甲沙生

CAS Name: 7-[2-(Dimethylamino)ethyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
Additional Names: 7-(2-dimethylaminoethyl)theophylline; 1,3-dimethyl-7-(2-dimethylaminoethyl)xanthine
Tradem...
Literature References: Prepn from theophylline and dimethyl-2-chloroethylamine: Moussalli et al., GB 669070 (1952), C.A. 47, 5435i (1953); Klosa, Arch. Pharm. 288, 301 (1955). Pharmacology: Balatre, Merlen, Therapie 11, 1146 (1956); Yago, Jpn. Circ. J. 26, 407 (1962).