其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Safranal CAS Registry Number: 116-26-7 2,3-二氢-2,2,6-三甲基苯甲醛

CAS Name: 2,6,6-Trimethyl-1,3-cyclohexadiene-1-carboxaldehyde
Additional Names: 2,2,6-trimethyl-4,6-cyclohexadien-1-aldehyde
Percent Composition: C 79.95%, H 9.39%, O 10.65%
Literature References: Prepn from picrocrocin: Kuhn, Winterstein, Ber. 67, 354 (1934). Synthesis: Kuhn, Wendt, Ber. 69, 1549 (1936); Könst et al., Tetrahedron Lett. 1974, 3175. Biogenetic synthesis: T. Kametani et al., Chem. Pharm. Bull. 29,105 (1981).

Metochalcone CAS Registry Number: 18493-30-6 美托查酮

CAS Name: 1-(2,4-Dimethoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one
Additional Names: 2',4,4'-trimethoxychalcone; 3'-(4-methoxyphenyl)-1-(2,4-dimethoxyphenyl)-2-propen-1-oneTrademarks: Lesidri...
Literature References: Prepn from p-methoxyacetophenone and 2,4-dimethoxybenzaldehyde: Freudenberg et al., Ber. 90, 957 (1957).

Acetaminophen CAS Registry Number: 103-90-2 对乙酰氨基苯酚

CAS Name: N-(4-Hydroxyphenyl)acetamide
Additional Names: 4'-hydroxyacetanilide; p-hydroxyacetanilide; p-acetamidophenol; p-acetaminophenol; p-acetylaminophenol; N-acetyl-p-aminophenol; paraceta...
Literature References: Prepn from p-nitrophenol: Morse, Ber. 11, 232 (1878); Tingle, Williams, Am. Chem. J. 37, 63 (1907); from p-aminophenol: Lumière et al., Bull. Soc. Chim. Fr. [3] 33, 785 (1905); Fierz-David, Kuster, Helv. Chim. Acta 22, 94 (1939); Wilbert, De Angelis, US 2998450 (1961 to Warner-Lambert); Bergmann, DE 453577; Chem. Zentralbl. 1928, I, 2663; Frdl. 16, 238; from p-hydroxyacetophenone hydrazone: Pearson et al., J. Am. Chem. Soc. 75, 5907 (1953). Toxicity data: G. A. Starmer et al., Toxicol. Appl. Pharmacol. 19, 20 (1971); D. C. Dahlin, S. D. Nelson, J. Med. Chem. 25, 885 (1982). Evaluation of renal effects: D. P. Sandler et al., N. Engl. J. Med. 320, 1238 (1989). Comprehensive description: J. E. Fairbrother, Anal. Profiles Drug Subs. 3, 1-109 (1974). Review of pharmacology: B. Ameer, D. J. Greenblatt, Ann. Intern. Med. 87, 202-209 (1977). Review of acetaminophen-induced hepatotoxicity: J. A. Hinson, Rev. Biochem. Toxicol. 2, 103-129 (1980); idem, Life Sci. 29, 107-116 (1981); and proposed protective agents: M. Davis, Semin. Liver Dis. 6, 138-147 (1986). For proposed toxic metabolite see Acetimidoquinone.

Dimethyl-p-phenylenediamine CAS Registry Number: 99-98-9 对氨基-N,N-二甲基苯胺

CAS Name: N,N-Dimethyl-1,4-benzenediamine
Additional Names: p-aminodimethylaniline
Percent Composition: C 70.55%, H 8.88%, N 20.57%
Literature References: Prepn from p-nitrosodimethylaniline which is obtained from dimethylaniline: Gattermann-Wieland, Praxis des Organischen Chemikers (de Gruyter, Berlin, 40th ed., 1961) p 273. By reduction of methyl orange: A. I. Vogel, Practical Organic Chemistry (Longmans, London, 3rd ed., 1959) p 624.

d-Camphorsulfonic Acid CAS Registry Number: 3144-16-9 右旋樟脑磺酸

CAS Name: 7,7-Dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid
Additional Names: 2-oxo-10-bornanesulfonic acid; 10-camphorsulfonic acid; camsylate; camphostyl; b-camphorsulfonic acid;...
Literature References: Prepn from powdered camphor, concd H2SO4 and acetic anhydride: Reychler, Bull. Soc. Chim. Fr. [3] 19, 120 (1898); Armstrong, Lowry, J. Chem. Soc. 81, 1447 (1902); Lipp, Knapp, Ber. 73B, 915 (1940). Structure: Loudon, J. Chem. Soc. 1933, 823; Komppa, J. Prakt. Chem. 162, 19 (1943).

Erythromycin Estolate CAS Registry Number: 3521-62-8 依托红霉素

CAS Name: Erythromycin 2'-propanoate dodecyl sulfate (salt)
Additional Names: erythromycin propionate lauryl sulfate; lauryl sulfate salt of the propionic acid ester of erythromycin; propionyle...
Literature References: Prepn from propionyl erythromycin: Stephens et al., J. Am. Pharm. Assoc. 48, 620 (1959); Bray, Stephens, US 3000874 (1961 to Lilly). Toxicity: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971). Comprehensive description: J. M. Mann, Anal. Profiles Drug Subs. 1, 101-117 (1972). For structure see Erythromycin.

Morphazinamide CAS Registry Number: 952-54-5 吗啉米特

CAS Name: N-(4-Morpholinylmethyl)pyrazinecarboxamide
Additional Names: N-morpholinomethylpyrazinamide; morfazinamide; morinamidePercent Composition: C 54.04%, H 6.35%, N 25.21%, O 14.40%
Literature References: Prepn from pyrazinamide, morpholine, and formalin: Felder, Tiepolo, DE 1129492 (1962 to Bracco).

a , a¢ -Dipyridyl CAS Registry Number: 366-18-7 2,2'-联吡啶

CAS Name: 2,2'-Bipyridine
Additional Names: 2,2'-dipyridylPercent Composition: C 76.90%, H 5.16%, N 17.94%
Literature References: Prepn from pyridine: Smith, J. Am. Chem. Soc. 46, 414 (1924). Manuf: Freeman, Ghosh, US 2962502 (1960 to I.C.I.). Absorption spectrum: P. Krumholz, J. Am. Chem. Soc. 73, 3487 (1951). Pharmacologic study: Bass et al., J. Pharmacol. Exp. Ther. 152, 104 (1966). Toxicity data: R. W. Grady et al., ibid. 196, 478 (1976).

Trimethyl Borate CAS Registry Number: 121-43-7 硼酸三甲酯

CAS Name: Boric acid trimethyl ester
Additional Names: methyl borate
Percent Composition: C 34.68%, H 8.73%, B 10.40%, O 46.19%
Literature References: Prepn from pyridine-boron trichloride complex: Gerrard, Lappert, Chem. Ind. (London) 1952, 53; from methanol and boric oxide, borax or boric acid: Schlesinger, J. Am. Chem. Soc. 75, 213 (1953); from methyl orthosilicates and boron halide: Wiberg, Krüerke, Z. Naturforsch. 8b, 608 (1953); from boric acid and methanol: Steinberg, Hunter, Ind. Eng. Chem. 49, 174 (1957). Several mfg processes: US 2689259; US 2884439; US 2937195 (to Callery Chem.); US 2880227 and US 2884440 (to Olin Mathieson); US 2855427 (to Am. Potash Chem.); US 2739979 (to USAEC). Acute toxicity: H. F. Smyth et al., Am. Ind. Hyg. Assoc. J. 23, 95 (1962).

Tremorine CAS Registry Number: 51-73-0 1,1-(2-丁炔亚基)二吡咯烷二盐酸盐

CAS Name: 1,1'-(2-Butyne-1,4-diyl)bispyrrolidine
Additional Names: 1,1'-(2-butynylene)dipyrrolidine; 1,4-dipyrrolidino-2-butyne
Percent Composition: C 74.95%, H 10.48%, N 14.57%
Literature References: Prepn from pyrrolidine + 1,4-dichloro-2-butyne: Maier, DE 896810 (1953 to BASF); Reppe et al., Ann. 596, 79 (1955); Biel, DiPierro, J. Am. Chem. Soc. 80, 4609 (1958). Review of chemical and biological studies: Karlen, Acta Pharm. Suec. 1970, 169-200; see also Kolla, Obvintseva, Farmakol. Toksikol. 36, 736-745 (1973).