其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Ouabagenin CAS Registry Number: 508-52-1 烏巴配基

CAS Name: (1b,3b,5b,11a)-1,3,5,11,14,19-Hexahydroxycard-20(22)-enolide
Additional Names: G-strophanthidin
Percent Composition: C 63.00%, H 7.82%, O 29.19%
Literature References: Prepn from ouabain with HCl in cold acetone: Mannich, Siewert, Ber. 75, 737 (1942). Review of structure: Reichstein, Reich, Annu. Rev. Biochem. 15, 155 (1946). Proof of this structure: Tamm et al., Helv. Chim. Acta 40, 1469 (1957), cf. Experientia 13, 185 (1957); Turner, Meschino, J. Am. Chem. Soc. 80, 4862 (1958); Volpp, Tamm, Helv. Chim. Acta 42, 1408, 1418 (1959).

Hydroxyamphetamine CAS Registry Number: 1518-86-1 羟基安非他命

CAS Name: 4-(2-Aminopropyl)phenol
Additional Names: dl-p-hydroxy-a-methylphenethylamine; dl-1-p-hydroxyphenyl-2-propylamine; p-hydroxyphenylisopropylamine; a-methyltyramine
Trademarks: Pared...
Literature References: Prepn from oxime of p-methoxyphenyl acetone: Mannich, Jacobsohn, Ber. 43, 189 (1910), DE 243546. From p-nitrobenzyl chloride and a salt of nitroethane: Hoover, Hass, J. Org. Chem. 12, 501 (1947).

Palladium Diacetate CAS Registry Number: 19807-27-3

CAS Name: Acetic acid palladium salt
Additional Names: bis(acetato)palladium; diacetatopalladium(II); palladium(II) acetate
Percent Composition: C 21.40%, H 2.69%, O 28.51%, Pd 47.40%
Literature References: Prepn from palladium sponge or palladium nitrate and glacial acetic acid: Morehouse et al., Chem. Ind. (London) 1964, 544; Stephenson et al., J. Chem. Soc. 1965, 3632; from hydrated palladium oxide and acetic acid: Hausman et al., FR 1403398 corresp to US 3318891 (1965, 1967 to Engelhard). Crystal structure of trimeric palladium acetate: Skapski, Smart, Chem. Commun. 1970, 658.

Ammonium Palmitate CAS Registry Number: 593-26-0 棕榈酸铵

CAS Name: Hexadecanoic acid ammonium salt
Additional Names: palmitic acid ammonium salt
Percent Composition: C 70.28%, H 12.90%, N 5.12%, O 11.70%
Literature References: Prepn from palmitic acid and excess 28-30% NH3 soln: Stumpf, Am. Paint J. 38, No. 45, 60, 64, 68 (1954), C.A. 48, 12428b (1954); from palmitic acid and ammonium carbonate: Reiling, US 3053867 (1962 to Boston Chem. Prods.).

Cetyl Palmitate CAS Registry Number: 540-10-3 十六酸十六酯

CAS Name: Hexadecanoic acid hexadecyl ester
Additional Names: palmitic acid hexadecyl ester; hexadecyl palmitate
Percent Composition: C 79.93%, H 13.42%, O 6.65%
Literature References: Prepn from palmitoyl chloride and cetyl alcohol in the presence of Mg: Paquot, Bouquet, Bull. Soc. Chim. Fr. 1947, 321; by CrO3H2SO4 oxidation of cetyl alcohol: Cymerman-Craig, Horning, J. Org. Chem. 25, 2098 (1960). Biosynthesis using inoculum of Nocardia salmonicolor: Davis, US 3169099 (1965 to Socony Mobil Oil).

p-Hydroxybenzoic Acid CAS Registry Number: 99-96-7 4-羟基苯甲酸

Percent Composition: C 60.87%, H 4.38%, O 34.75%
Literature References: Prepn from p-bromophenol: Gilinan, Arntzen, J. Am. Chem. Soc. 69, 1537 (1947); from p-hydroxybenzaldehyde: Pearl, J. Org. Chem. 12, 85 (1947); from phenol + potassium ethyl carbonate: Jones, Chem. Ind. (London) 1958, 228; from potassium phenolate + CO2: GB 942418 (1963 to Inventa). A metabolic product of Penicillium patulum: Tanenbaum, Bassett, Biochim. Biophys. Acta 28, 21 (1958).

Quinizarin CAS Registry Number: 81-64-1 1,4-二羟基蒽醌

CAS Name: 1,4-Dihydroxy-9,10-anthracenedione
Additional Names: 1,4-dihydroxyanthraquinone; C.I. 58050
Percent Composition: C 70.00%, H 3.36%, O 26.64%
Literature References: Prepn from p-chlorophenol and phthalic anhydride: Reynolds, Bigelow, J. Am. Chem. Soc. 48, 420 (1926); US 1845632, C.A. 26, 2203; Org. Synth. coll. vol. I, 476 (New York, 1941). Prepn from hydroquinone: Gattermann-Wieland, Praxis des Organischen Chemikers (de Gruyter, Berlin, 40th ed., 1961) p 299. Also prepd from diazotized p-chloroaniline and phthalic anhydride: GB 373999, C.A. 27, 3946 (1933); by treating anthraquinone with ammonium persulfate in sulfuric acid: Wacker, J. Prakt. Chem. [2] 54, 90 (1896). Purification from contaminating purpurin: Org. Synth. (loc. cit.). See also: Colour Index vol. 4 (3rd ed., 1971) p 4515.

o-Phenylphenol CAS Registry Number: 90-43-7 2-苯基苯酚

CAS Name: (1,1'-Biphenyl)-2-ol
Additional Names: 2-biphenylol; orthoxenol; o-hydroxydiphenyl; 2-hydroxydiphenyl
Trademarks: Dowicide 1 (Dow)
Percent Composition: C 84.68%, H 5.92%, O 9.40...
Literature References: Prepn from phenyl ether: Lüttringhaus, Sääf, Ann. 542, 241 (1939); from dibenzofuran: Gilman, Esmay, J. Am. Chem. Soc. 75, 2947 (1953); Müller, US 2862035 (1958 to Bayer). Purification: Widiger, US 3087969 (1963 to Dow). Toxicity data: Hodge et al., J. Pharmacol. Exp. Ther. 104, 202 (1952). Review of carcinogenic risk: IARC Monographs 30, 329-344 (1983).

a -Phenylbutyramide CAS Registry Number: 90-26-6 2-苯基丁酰胺

CAS Name: a-Ethylbenzeneacetamide
Additional Names: 2-phenylbutanamide; a-ethyl-a-phenylacetamide; a-phenyl-a-ethylacetamidePercent Composition: C 73.59%, H 8.03%, N 8.58%, O 9.80%
Literature References: Prepn from phenylethylacetylurea: DE 249241 (1912 to Bayer); Chem. Zentralbl. 1912, II, 396; Frdl. 10, 1164.

o-(p-Anisoyl)benzoic Acid CAS Registry Number: 1151-15-1 2-(4-甲氧基苯甲酰基)苯甲酸

CAS Name: 2-(4-Methoxybenzoyl)benzoic acidPercent Composition: C 70.31%, H 4.72%, O 24.97%
Literature References: Prepn from phthalic anhydride and anisole: Meyer, Turnau, Monatsh. Chem. 30, 486 (1909). Alternate route: Arcus, Marks, J. Chem. Soc. 1956, 1627.