其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Flufenamic Acid CAS Registry Number: 530-78-9 氟芬那酸

CAS Name: 2-[[3-(Trifluoromethyl)phenyl]amino]benzoic acid
Additional Names: N-(a,a,a-trifluoro-m-tolyl)anthranilic acid; 3'-trifluoromethyldiphenylamine-2-carboxylic acidTrademarks: Achless (T...
Literature References: Prepn from m-aminobenzotrifluoride and o-iodobenzoic acid: Wilkinson, Finar, J. Chem. Soc. 1948, 32. Pharmacology: Winder et al., Arthritis Rheum. 6, 36 (1963); 12, 472 (1969). Antiviral activity: Inglot, J. Gen. Virol. 4, 203 (1969). Toxicity data: Zoni et al., Farmaco Ed. Sci. 26, 191 (1971). Comprehensive description: E. Abignente, P. deCaprariis, Anal. Profiles Drug Subs. 11, 313-346 (1982).

Inosinic Acid CAS Registry Number: 131-99-7 肌苷5'-单磷酸

CAS Name: 5'-Inosinic acid
Additional Names: 5-inosinic acid; muscle inosinic acid; t-inosinic acid; hypoxanthine riboside-5-phosphoric acid; IMP
Percent Composition: C 34.49%, H 3.76%, N 16...
Literature References: Prepn from meat extract: Levene, Bass, Nucleic Acids (New York, 1931) p 229; from dried sardines: Yoshida, Kageyama, JP 56 732 (1956 to Ajinomoto), C.A. 51, 3870b (1957). Structure: Levene, Bass, op. cit., pp 187-192; Bredereck, Ber. 66, 198 (1933); Levene, Tipson, J. Biol. Chem. 111, 313 (1935). Also prepd from muscle by enzymatic deamination of muscle adenylic acid: Ostern, Biochem. Z. 254, 65 (1932); by hydrolysis of inosine triphosphate: Kleinzeller, Biochem. J. 36, 729 (1942). Studies on the enzymatic synthesis: Greenberg, J. Biol. Chem. 190, 611 (1951); Korn et al., ibid. 217, 875 (1955). Microbial fermentation method using mutant strains of Micrococcus glutamicus: Kinoshita et al., US 3232844 (1966 to Kyowa).

Methionic Acid CAS Registry Number: 503-40-2 甲基二磺酸

CAS Name: Methanedisulfonic acid
Percent Composition: C 6.82%, H 2.29%, O 54.49%, S 36.40%
Literature References: Prepn from methane + sulfur trioxide: Snyder, Grosse, US 2493038 (1950 to Houdry Process); by H2SO4 oxidation of acetic acid: Schwab, Neuwirth, Ber. 90, 567 (1957); from MeSO3H + SO3: Crowder, Gilbert, US 2842589 (1958 to Allied Chem.). Prepn of aluminum salt: Christian, Jenkins, J. Am. Pharm. Assoc. 39, 633 (1950); US 2504107 (1950 to Purdue Res. Found.).

Methyl Nitrate CAS Registry Number: 598-58-3 硝酸甲酯

CAS Name: Nitric acid methyl ester
Percent Composition: C 15.59%, H 3.93%, N 18.18%, O 62.30%
Literature References: Prepn from methanol and nitric acid in the presence of sulfuric acid: Black, Babers, Org. Synth. coll. vol. II, 412 (1943).

Neohesperidin Dihydrochalcone CAS Registry Number: 20702-77-6 新橙皮苷二氢查尔酮

CAS Name: 1-[4-[[2-O-(6-Deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-1-propanone
Additional Names: 3,5-dihydroxy-4-(3-hydroxy-4-methoxyhy...
Literature References: Prepn from naringen, a flavanone glycoside occurring naturally in grapefruit: Horowitz, Gentile, US 3087821 and US 3375242 (1963, 1968, both to U.S. Secy. Agr.); Robertson et al., Ind. Eng. Chem. Prod. Res. Dev. 13, 125 (1974). Sweetening effect: Inglett et al., J. Food Sci. 34, 101 (1969). Chromatography: Gentile, Horowitz, J. Chromatogr. 63, 467 (1971); J. F. Fisher, J. Agric. Food Chem. 25, 682 (1977). Subchronic oral toxicity study: B. A. R. Lina et al., Food Chem. Toxicol. 28, 507 (1990). Review: P. J. Pratter, Perfum. Flavor. 5, 12-18 (1981).

n-Butyl Acrylate CAS Registry Number: 141-32-2 丙烯酸丁酯(BA)

CAS Name: 2-Propenoic acid butyl ester
Additional Names: acrylic acid n-butyl ester
Percent Composition: C 65.60%, H 9.44%, O 24.97%
Literature References: Prepn from n-butanol and methyl acrylate: Rehberg, Org. Synth. coll. vol. III, 146 (1955). Toxicity study: H. F. Smyth et al., Arch. Ind. Hyg. Occup. Med. 4, 119 (1951).

Silver Perchlorate CAS Registry Number: 7783-93-9 高氯酸银

Percent Composition: Ag 52.03%, Cl 17.10%, O 30.87%
Literature References: Prepn from NOClO4 + AgBr: Markowitz et al., J. Inorg. Nucl. Chem. 16, 159 (1960).

o-Nitroaniline CAS Registry Number: 88-74-4 2-硝基苯胺

Additional Names: o-Nitraniline
Percent Composition: C 52.18%, H 4.38%, N 20.28%, O 23.17%
Literature References: Prepn from o-dinitrobenzene: Meisenheimer, Hesse, Ber. 52, 1166 (1919); from o-nitroaniline-p-sulfonic acid: Ehrenfeld, Puterbaugh, Org. Synth. coll. vol. I, 388 (1941); from y-o-dinitrosobenzene: Boyer et al., J. Am. Chem. Soc. 77, 5688 (1955).

Orthanilic Acid CAS Registry Number: 88-21-1 2-氨基苯磺酸

CAS Name: 2-Aminobenzenesulfonic acid
Additional Names: o-sulfanilic acid; o-anilinesulfonic acid
Percent Composition: C 41.61%, H 4.07%, N 8.09%, O 27.71%, S 18.51%
Literature References: Prepn from o-nitrobenzenesulfonyl chloride: Wertheim, Org. Synth. coll. vol. II, 271 (1943).

Mercurophen CAS Registry Number: 52486-78-9

Additional Names: Sodium 4-(hydroxymercuri)-2-nitrophenolate; sodium hydroxymercuri-o-nitrophenolate; 4-(hydroxymercuri)-2-nitrophenol sodium salt
Percent Composition: C 19.08%, H 1.07%, Hg 53....
Literature References: Prepn from o-nitrophenol and Hg(OCOCH3)2: Schamberg et al., US 1390972 (1922). Structure: Malcolm, J. Bacteriol. 22, 403 (1931).