其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

b -Chloroethyl Acetate CAS Registry Number: 542-58-5 2-氯乙酸乙酯

CAS Name: 2-Chloroethanol acetate
Percent Composition: C 39.20%, H 5.76%, Cl 28.93%, O 26.11%
Literature References: Prepn from ethylene oxide and acetyl chloride: E. L. Gustus, P. G. Stevens, J. Am. Chem. Soc. 55, 378 (1933). Physical properties: Ind. Eng. Chem. 32, 880 (1940).

Tetrahydrozoline CAS Registry Number: 84-22-0 四氢唑啉

CAS Name: 4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazole
Additional Names: 2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline; tetryzoline
Percent Composition: C 77.96%, H 8.05%...
Literature References: Prepn from ethylenediamine, ethylenediamine hydrochloride, and methyl 1,2,3,4-tetrahydro-1-naphthoate: Synerholm et al., US 2731471 (1956 to Sahyun Labs.). Use as potentiator for veterinary depressants: Gardocki et al., US 2842478 (1958 to Pfizer).

Hydrogen Tetracarbonylferrate(II) CAS Registry Number: 17440-90-3

CAS Name: (T-4)-Dihydrogen tetracarbonylferrate(2-)
Additional Names: iron hydrocarbonyl; iron tetracarbonyl dihydride
Percent Composition: C 28.28%, H 1.19%, Fe 32.87%, O 37.67%
Literature References: Prepn from Fe(CO)5: Blanchard, Coleman, Inorg. Synth. 2, 243 (1946); Sternberg et al., J. Am. Chem. Soc. 79, 6116 (1957); Bishop et al., J. Chem. Soc. 1959, 2484.

Benzyl Formate CAS Registry Number: 104-57-4 甲酸苄酯

CAS Name: Formic acid phenylmethyl ester
Additional Names: formic acid benzyl ester
Percent Composition: C 70.57%, H 5.92%, O 23.50%
Literature References: Prepn from formic acid and benzyl alcohol: Mailhe, Chem. Ztg. 35, 508 (1911).

Benzo[f]quinoline CAS Registry Number: 85-02-9 苯并[f]喹啉

Additional Names: b-Naphthoquinoline; 5,6-benzoquinoline; naphthopyridine
Percent Composition: C 87.12%, H 5.06%, N 7.82%
Literature References: Prepn from from b-naphthylamine by the Skraup reaction: Knueppel, Ber. 29, 703 (1896); Clem, Hamilton, J. Am. Chem. Soc. 62, 2349 (1940); Uhle, Jacobs, J. Org. Chem. 10, 76 (1945).

Allopregnan-20 a -ol-3-one CAS Registry Number: 516-59-6 5alpha-孕甾烷-20alpha-醇-3-酮

CAS Name: (5a,20S)-20-Hydroxypregnan-3-one
Additional Names: 20a-hydroxy-5a-pregnan-3-one; 20a-hydroxy-3-oxo-5a-pregnane
Percent Composition: C 79.19%, H 10.76%, O 10.05%
Literature References: Prepn from funtumidine: Janot et al., Bull. Soc. Chim. Fr. 1960, 1669.

L -Glutamic Acid 5-Ethyl Ester CAS Registry Number: 1119-33-1 L-谷氨酸 γ-乙酯

Additional Names: L-Glutamic acid g-ethyl ester; g-ethyl L-glutamate
Trademarks: Glutestere
Percent Composition: C 47.99%, H 7.48%, N 8.00%, O 36.53%
Literature References: Prepn from glutamic acid, ethanol, and hydrogen chloride: Hegedus, Helv. Chim. Acta 31, 737 (1948); Pravda, Collect. Czech. Chem. Commun. 24, 2083 (1959); CS 88344 (1959), C.A. 54, 8660h (1960).

Buramate CAS Registry Number: 4663-83-6 布拉氨酯

CAS Name: (Phenylmethyl)carbamic acid 2-hydroxyethyl ester
Additional Names: benzylcarbamic acid 2-hydroxyethyl ester; 2-hydroxyethyl benzylcarbamate; glycol benzylcarbamateTrademarks: Hyamate ...
Literature References: Prepn from glycol cyclic carbonate and benzylamine: Viard, GB 689705 (1953 to Chauny Cirey).

Tetroquinone CAS Registry Number: 319-89-1 四羟基苯醌

CAS Name: 2,3,5,6-Tetrahydroxy-2,5-cyclohexadiene-1,4-dione
Additional Names: tetrahydroxy-p-benzoquinone; tetrahydroxyquinone; THQPercent Composition: C 41.88%, H 2.34%, O 55.78%
Literature References: Prepn from glyoxal: A. J. Fatiadi, W. F. Sager, Org. Synth. coll. vol. V, 1011 (1973). Clinical evaluation for ophthalmic fibrosis: R. Ching, Eye Ear Nose Throat Mon. 50, 101, 144 (1971).

Trimethoprim CAS Registry Number: 738-70-5 甲氧苄氨嘧啶

CAS Name: 5-[(3,4,5-Trimethoxyphenyl)methyl]-2,4-pyrimidinediamine
Additional Names: 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine
Trademarks: Instalac (Virbac); Monotrim (Duphar); Prolop...
Literature References: Prepn from guanidine and b-ethoxy-3,4,5-trimethoxybenzylbenzalnitrile: Stenbuck, Hood, US 3049544 (1962 to Burroughs Wellcome); Hoffer, US 3341541 (1967 to Hoffmann-La Roche). Improved synthesis: B. Roth et al., J. Med. Chem. 23, 379, 535 (1980). Toxicity data: Yamamoto et al., Chemotherapy (Tokyo) 21, 187 (1973). Review: Burchall in Antibiotics vol. 3, J. W. Corcoran, F. E. Hahn, Eds. (Springer-Verlag, New York, 1975) pp 304-320. Comprehensive description: G. J. Manius, Anal. Profiles Drug Subs. 7, 445-475 (1978). Review of antibacterial activity, pharmacokinetics and therapeutic use: R. N. Brogden et al., Drugs 23, 405-430 (1982).