其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Heptoxime CAS Registry Number: 530-97-2 1,2-环庚二酮二肟

CAS Name: 1,2-Cycloheptanedione dioxime
Percent Composition: C 53.83%, H 7.74%, N 17.94%, O 20.49%
Literature References: Prepn from cycloheptanone: Vander et al., J. Org. Chem. 14, 836 (1949); Belcher et al., J. Chem. Soc. 1958, 2743. Review: Banks, Nicholas, USAEC ISC-737 (1956).

p-Biphenylamine CAS Registry Number: 92-67-1 4-氨基联苯

CAS Name: [1,1'-Biphenyl]-4-amine
Additional Names: 4-aminobiphenyl; p-aminodiphenyl; anilinobenzene; xenylamine
Percent Composition: C 85.17%, H 6.55%, N 8.28%
Literature References: Prepn from diazoaminobenzene: Heusler, Ann. 260, 232 (1890). Review of carcinogenicity studies: IARC Monographs 1, 74-79 (1972).

o-Nitrobiphenyl CAS Registry Number: 86-00-0 2-硝基联苯

CAS Name: 2-Nitro-1,1'-biphenyl
Additional Names: o-nitrodiphenyl; ONB
Percent Composition: C 72.35%, H 4.55%, N 7.03%, O 16.06%
Literature References: Prepn from diazotized o-nitroaniline and benzene by a modified Gomberg reaction: Elks et al., J. Chem. Soc. 1940, 1284. Prepd industrially by direct nitration of biphenyl (yields ~50% para, 35% ortho).

Benzopurpurine 4B CAS Registry Number: 992-59-6 苯紫红素4B

CAS Name: 3,3'-[(3,3'-Dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-1-naphthalenesulfonic acid] disodium salt
Additional Names: disodium o-tolidinediazobis(1-naphthylamine-4-sulfonate)...
Literature References: Prepn from diazotized o-tolidine and sodium 4-amino-1-naphthalenesulfonate: DE 35615 (1885 to A. G. für Anilinfabrikation Berlin), Frdl. 1, 473; F. J. Welcher, Organic Analytical Reagents vol. 4 (Van Nostrand Co., New York, 1948) pp 338-339; Colour Index vol. 4 (3rd ed., 1971) p 4189. See also: H. J. Conn's Biological Stains, R. D. Lillie, Ed. (Williams Wilkins, Baltimore, 9th ed., 1977) p 154.

p-Dibromobenzene CAS Registry Number: 106-37-6 对二溴苯

Percent Composition: C 30.55%, H 1.71%, Br 67.74%
Literature References: Prepn from diazotized p-bromoaniline: Fry, Grote, J. Am. Chem. Soc. 48, 710 (1926); by catalytic bromination of bromobenzene: Ferguson et al., ibid. 76, 1250 (1954).

Beryllium Borohydride CAS Registry Number: 17440-85-6 四氢硼酸铍

CAS Name: Beryllium tetrahydroborate(1-)
Percent Composition: B 55.87%, Be 23.29%, H 20.84%
Literature References: Prepn from diborane and dimethylberyllium: Burg, Schlesinger, J. Am. Chem. Soc. 62, 3425 (1940); from LiBH4 and BeCl2: Schlesinger et al., ibid. 75, 212 (1953).

Iothion CAS Registry Number: 534-08-7 1,3-二碘-2-丙醇

CAS Name: 1,3-Diiodo-2-propanol
Additional Names: iopropane; 1,3-diiodo-2-hydroxypropane; a-diiodohydrin; 1,3-diiodoisopropyl alcohol
Percent Composition: C 11.55%, H 1.94%, I 81.38%, O 5.13...
Literature References: Prepn from dichlorohydrin and KI: Claus, Ann. 168, 24 (1873); from glycerol, HCl and NaI: Lusignani, Boll. Chim. Farm. 78, 557 (1939), C.A. 34, 2322 (1940).

Diacetyldihydromorphine CAS Registry Number: 509-71-7 双醋氢吗啡

CAS Name: (5a,6a)-4,5-Epoxy-17-methylmorphinan-3,6-diol diacetate (ester)
Additional Names: dihydroheroin; paralaudin
Percent Composition: C 67.91%, H 6.78%, N 3.77%, O 21.54%
Literature References: Prepn from dihydromorphine: Eddy, Howes, J. Pharmacol. 53, 430 (1935); Small, Mallonee, J. Org. Chem. 12, 558-566 (1947); K. W. Bentley, The Chemistry of the Morphine Alkaloids (Oxford, 1954).

Methyl Fluorosulfonate CAS Registry Number: 421-20-5 氟磺酸甲酯

CAS Name: Fluorosulfuric acid methyl ester
Additional Names: methyl fluorosulfate; methyl fluosulfonate
Trademarks: Magic Methyl (Aldrich)
Percent Composition: C 10.53%, H 2.65%, F 16.65%...
Literature References: Prepn from dimethyl ether and fluosulfonic acid: J. Meyer, G. Schramm, Z. Anorg. Allg. Chem. 206, 24 (1932); from dimethyl sulfate and fluosulfonic acid: R. W. Alder, Chem. Ind. (London) 1973, 983. Electrochemical prepn: J. P. Coleman, D. Pletcher, Tetrahedron Lett. 1974, 147. Powerful methylating agent: M. G. Ahmed et al., Chem. Commun. 1968, 1533. Human toxicity: D. M. W. vanden Ham, D. van der Meer, Chem. Eng. News 54, 5 (Aug. 30, 1976); eidem, Chem. Ind. (London) 1976, 782. Toxicity study: M. Hite et al., Am. Ind. Hyg. Assoc. J. 40, 600 (1979).

Michler's Ketone CAS Registry Number: 90-94-8 4,4'-二(N,N-二甲氨基)二苯甲酮

CAS Name: Bis[4-(dimethylamino)phenyl]methanone
Additional Names: 4,4'-bis(dimethylamino)benzophenone; tetramethyldiaminobenzophenone
Percent Composition: C 76.09%, H 7.51%, N 10.44%, O 5.96...
Literature References: Prepn from dimethylaniline + phosgene: Michler, Ber. 9, 716 (1876); Michler, Dupertius, ibid. 1900; from dimethylaniline, AlCl3 and CCl4: Fierz, Koechlin, Helv. Chim. Acta 1, 218 (1918).