其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Cerous Nitrate CAS Registry Number: 10108-73-3 三硝酸铈

Percent Composition: Ce 42.96%, N 12.88%, O 44.15%
Literature References: Prepn from Ce sulfate and Ca(NO3)2: Blumenfeld, US 2166702 (1939 to Soc. de Produits Chimiques des Terres Rares); in separation of cerium from other rare earths: Pierce, Butler, Inorg. Synth. 2, 51 (1946); Scargill et al., J. Inorg. Nucl. Chem. 4, 304 (1957). For physical and chemical properties see USAEC IDO-14504, 126 pp (1961). Toxicity study: Bruce et al., Toxicol. Appl. Pharmacol. 5, 750 (1963).

Chloracetyl Chloride CAS Registry Number: 79-04-9 氯乙酰氯

Percent Composition: C 21.27%, H 1.78%, Cl 62.78%, O 14.17%
Literature References: Prepn from chloroacetic acid and benzoyl chloride: Brown, J. Am. Chem. Soc. 60, 1325 (1938); by chlorination of ketene: Erickson, Prill, J. Org. Chem. 23, 141 (1958); Prill, US 2889365 (1959 to Monsanto); from chloroacetic acid and pyrocatechylphosphorus trichloride: Gross, Gloede, Ber. 96, 1387 (1963). Manuf from chloroacetic acid and POCl2: MacKenzie, Morris, US 2848491 (1958 to Dow); from ketene: Prill, US 2889365 (1959 to Monsanto). Physical data: McDonald et al., J. Chem. Eng. Data 4, 311 (1959).

Coproergostane CAS Registry Number: 511-21-7 (5beta)-麦角甾烷

CAS Name: 5b-Ergostane
Additional Names: pseudoergostane
Percent Composition: C 86.97%, H 13.03%
Literature References: Prepn from cholanic acid: Fernholz, Ber. 69, 1792 (1936).

Choline Salicylate CAS Registry Number: 2016-36-6 水杨酸胆碱

CAS Name: 2-Hydroxy-N,N,N-trimethylethanaminium salt with 2-hydroxybenzoic acid (1:1)
Additional Names: (2-hydroxyethyl)trimethylammonium salicylate; choline salicylic acid salt; salicylic acid...
Literature References: Prepn from choline chloride and sodium salicylate: Broh-Kahn, Int. Rec. Med. 173, 219 (Apr. 1960); cf. Johnson, GB 8031 (1919); Broh-Kahn et al., US 3069321 (1962 to Labs. for Pharmaceut. Dev.). Variations of process: BE 583513 (1960 to Mundipharma, AG).

Chromous Oxalate CAS Registry Number: 814-90-4 乙二酸,铬(2+)盐(1:1)

Percent Composition: C 17.16%, Cr 37.13%, O 45.71%
Literature References: Prepn from chromous acetate and oxalic acid: Chromium Vol. 1, M. J. Udy, Ed., A.C.S. Monograph Ser., no. 132 (Reinhold, New York, 1956) p 227; from chromous sulfate and sodium oxalate: Lux, Illmann, Ber. 91, 2143 (1958). Reported as monohydrate (Udy, loc. cit.) or dihydrate (Lux, Illman, loc. cit.).

Citrazinic Acid CAS Registry Number: 99-11-6 2,6-二羟基异烟酸

CAS Name: 1,2-Dihydro-6-hydroxy-2-oxo-4-pyridinecarboxylic acid
Additional Names: 2,6-dihydroxyisonicotinic acid; 2,6-dihydroxy-4-pyridinecarboxylic acid
Percent Composition: C 46.46%, H 3.2...
Literature References: Prepn from citric acid with aq NH3 at 140-160° under pressure: Bavley, Hamilton, US 2729647 (1956 to Pfizer). Purification: Bavley et al., US 2738352 (1956 to Pfizer).

b -Coniceine CAS Registry Number: 538-90-9 2-[(1Z)-1-丙烯-1-基]哌啶

CAS Name: 2-(1-Propenyl)piperidine
Additional Names: a-allylpiperidine
Percent Composition: C 76.74%, H 12.07%, N 11.19%
Literature References: Prepn from conhydrine: Löffler, Friederick, Ber. 42, 107 (1909); Löffler, Tschunke, ibid. 929.

Hydrohydrastinine CAS Registry Number: 494-55-3 氢乙种北美黄连碱

CAS Name: 5,6,7,8-Tetrahydro-6-methyl-1,3,dioxolo[4,5-g]isoquinoline
Percent Composition: C 69.09%, H 6.85%, N 7.32%, O 16.73%
Literature References: Prepn from cotarnine, q.v.: Topchiev, J. Appl. Chem. USSR 6, 529 (1933), C.A. 28, 2718 (1934); Clayson, J. Chem. Soc. 1949, 2016; Schneider, Müller, Ann. 615, 34 (1958); Knabe, Arch. Pharm. 292, 652 (1959). See also: Hydrastinine, Hydrocotarnine.

Chromium Carbonyl CAS Registry Number: 13007-92-6 六羰基铬

Additional Names: Chromium hexacarbonyl
Percent Composition: C 32.75%, Cr 23.63%, O 43.62%
Literature References: Prepn from Cr salts and CO in the presence of a Grignard reagent: Owen et al., Inorg. Synth. 3, 156 (1950); in the presence of Mg and ether: Wender, US 3012858 (1961 to Diamond Alkali); in the presence of Na and diglyme: Podall et al., J. Am. Chem. Soc. 83, 2057 (1961); in the presence of Na and an aromatic hydrocarbon: Pruett, Wyman, US 3053629 (1962 to Union Carbide); in the presence of I2 and a nitrile: Wotiz, US 3100687 (1963 to Diamond Alkali). Toxicity study: Strohmeier, Z. Naturforsch. 19b, 540 (1964).

Cupric Chromate(VI) CAS Registry Number: 13548-42-0

Additional Names: Neutral cupric chromate
Percent Composition: Cr 28.96%, Cu 35.39%, O 35.65%
Literature References: Prepn from CuCO3, Na2CrO4 and CrO3: Briggs, J. Chem. Soc. 1929, 242; from CuO and CrO3: Campbell, Lemaire, Can. J. Res. 25B, 243 (1947); from Cu(OH)2 and K2Cr2O7: Winter et al., in Kirk-Othmer Encyclopedia of Chemical Technology vol. 6 (Interscience, New York, 2nd ed., 1965) p 270.