其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

p,p ¢ -Diaminodiphenylmethane CAS Registry Number: 101-77-9 4,4'-二氨基二苯甲烷

CAS Name: 4,4'-Methylenebis[benzenamine]
Additional Names: 4,4'-methylenedianiline
Percent Composition: C 78.75%, H 7.12%, N 14.13%
Literature References: Prepn from aniline and formaldehyde: Scanlon, J. Am. Chem. Soc. 57, 887 (1935); by hydrogenolysis of p,p¢-diaminobenzophenone with LiAlH4: Conover, Tarbell, ibid. 72, 3586 (1950). Identified as causative agent in clinical outbreak of hepatoxicity called Epping Jaundice: H. Kopelman et al., Br. Med. J. 1, 514 (1966); D. B. McGill, J. D. Motto, N. Engl. J. Med. 291, 278 (1974). Review of toxicology and human exposure: Toxicological Profile for Methylenedianiline (PB99-102568, 1998) 194 pp.

Cumidine CAS Registry Number: 99-88-7 对异丙基苯胺

CAS Name: 4-(1-Methylethyl)benzenamine
Additional Names: 4-aminocumene; p-isopropylaniline; 4-amino-1-isopropylbenzene; b-(4-aminophenyl)propane
Percent Composition: C 79.95%, H 9.69%, N 10....
Literature References: Prepn from aniline and isopropyl alcohol: Louis, Ber. 16, 111 (1883); by nitration and subsequent reduction of cumene: Constam, Goldschmidt, Ber. 21, 1157 (1898); Vavon, Callier, Bull. Soc. Chim. Fr. [4] 41, 677 (1927).

Cyclohexanecarboxylic Acid CAS Registry Number: 98-89-5 环己甲酸

Additional Names: Hexahydrobenzoic acid
Percent Composition: C 65.60%, H 9.44%, O 24.97%
Literature References: Prepn from anisic acid: Lumsden, J. Chem. Soc. 87, 90 (1905); from 2-chlorocycloheptanone: Gutsche, J. Am. Chem. Soc. 71, 3513 (1949); by carbonation of cyclohexylmagnesium chloride: Wagner, Moore, ibid. 72, 974 (1950); from cyclohexane + KI + active Ni: Reppe et al., Ann. 582, 38 (1953); by oxidation of cycloheptanone: Payne, Smith, J. Org. Chem. 22, 1680 (1957); from cyclohexane + HCOOH or CO2: McKursick et al., J. Am. Chem. Soc. 82, 723 (1960); McKursick, US 2940913 (1960 to du Pont).

Phenacylamine CAS Registry Number: 613-89-8 2-氨基苯乙酮

CAS Name: 2-Amino-1-phenylethanone
Additional Names: 2-aminoacetophenone; a-aminoacetophenone; w-aminoacetophenone
Percent Composition: C 71.09%, H 6.71%, N 10.36%, O 11.84%
Literature References: Prepn from a-phenylethylamine: H. E. Baumgarten, J. M. Petersen, J. Am. Chem. Soc. 82, 459 (1960); eidem, Org. Synth. coll. vol. V, 909 (1973).

b -Bromoisovaleric Acid CAS Registry Number: 5798-88-9

CAS Name: 3-Bromo-3-methylbutanoic acid
Percent Composition: C 33.17%, H 5.01%, Br 44.14%, O 17.68%
Literature References: Prepn from b,b-dimethylacrylic acid and HBr: Auwers, Ber. 28, 1130 (1895); from b-isovalerolactone and HBr: Gresham et al., J. Am. Chem. Soc. 76, 486 (1954).

Dibenzalacetone CAS Registry Number: 538-58-9 二亚苄叉丙酮DBA

CAS Name: 1,5-Diphenyl-1,4-pentadien-3-one
Additional Names: dibenzylidene acetone; distyryl ketone
Percent Composition: C 87.15%, H 6.02%, O 6.83%
Literature References: Prepn from benzaldehyde + acetone: Conrad, Dolliver, Org. Synth. 12, 22 (1939); Haslam, US 2719863 (1955 to du Pont); Tokár et al., Acta Chim. Acad. Sci. Hung. 19, 83 (1959). Prepn of geometrical isomers: Dinwiddie et al., J. Org. Chem. 27, 327 (1962).

Benzylaniline CAS Registry Number: 103-32-2 N-苄基苯胺

CAS Name: N-Phenylbenzenemethanamine
Additional Names: N-phenylbenzylamine; benzylphenylamine
Percent Composition: C 85.21%, H 7.15%, N 7.64%
Literature References: Prepn from benzyl alc and aniline in the presence of KOH: Sprinzak, J. Am. Chem. Soc. 78, 3207 (1956); from benzaldehyde and aniline in the presence of NaBH4: Schellenberg, J. Org. Chem. 28, 3259 (1963).

o-Benzylphenol CAS Registry Number: 28994-41-4 2-苄基苯酚

CAS Name: 2-(Phenylmethyl)phenol
Additional Names: a-phenyl-o-cresol; (2-hydroxydiphenyl)methane
Percent Composition: C 84.75%, H 6.57%, O 8.68%
Literature References: Prepn from benzyl bromide and sodium phenoxide: Kornblum, Lurie, J. Am. Chem. Soc. 81, 2711 (1959).

Cholane CAS Registry Number: 548-98-1

Percent Composition: C 87.19%, H 12.81%
Literature References: Prepn from bisnorcholyl methyl ketone: Wieland et al., Z. Physiol. Chem. 161, 80, 109 (1926); from potassium cholanate: Kazuno et al., Proc. Jpn. Acad. 28, 416 (1952).

Phytochlorin CAS Registry Number: 19660-77-6 二氢卟吩E6

CAS Name: 18-Carboxy-20-(carboxymethyl)-8-ethenyl-13-ethyl-2,3-dihydro-3,7,12,17-tetramethyl-21H,23H-porphine-2-propanoic acid
Additional Names: chlorin e6; phytochlorin e
Percent Compositio...
Literature References: Prepn from broccoli-leaf extract: Wall, US 2555583 (1951 to U.S.D.A.). Review: H. Fischer, A. Stern, Die Chemie des Pyrrols vol. II, 2 (Leipzig, 1940) pp 91-94; The Chlorophylls, L. P. Vernon, G. R. Seely, Eds. (Academic Press, New York, 1966) pp 9, 12, 71, 90, 95, 98, 142.