其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Ammonium Tetrachloroaluminate CAS Registry Number: 7784-14-7

Additional Names: Aluminum ammonium chloride; ammonium chloroaluminate
Percent Composition: Al 14.44%, Cl 75.90%, H 2.16%, N 7.50%
Literature References: Prepn from AlCl3 and NH4Cl: Friedman, Taube, J. Am. Chem. Soc. 72, 2236 (1950).

Aluminum Borohydride CAS Registry Number: 16962-07-5 硼氢化铝

CAS Name: Aluminum tetrahydroborate
Percent Composition: Al 37.73%, B 45.35%, H 16.91%
Literature References: Prepn from alkali metal hydride and aluminum halide: Schlesinger et al., J. Am. Chem. Soc. 75, 209 (1953); Hinkamp, Hnizda, Ind. Eng. Chem. 47, 1560 (1955); Kollonitsch, Fuchs, Nature 176, 1081 (1955); Hinkamp, US 2854312 (1958 to Ethyl Corp.); Schechter, US 2913306 (1959 to Callery Chem.); from trimethylaluminum and diborane: Schlesinger et al., J. Am. Chem. Soc. 61, 536 (1939).

Ergostane CAS Registry Number: 511-20-6 5alpha-麦角甾烷

CAS Name: 5a-Ergostane
Percent Composition: C 86.97%, H 13.03%
Literature References: Prepn from allocholanic acid: Fernholz, Ber. 69, 1792 (1938).

Allopregnan-20 b -ol-3-one CAS Registry Number: 516-58-5

CAS Name: (5a,20R)-20-Hydroxypregnan-3-one
Additional Names: 20b-hydroxy-5a-pregnan-3-one; 20b-hydroxy-3-oxo-5a-pregnane
Percent Composition: C 79.19%, H 10.76%, O 10.05%
Literature References: Prepn from allopregnane-3b,20b-diol-3-acetate: Rubin et al., J. Am. Chem. Soc. 73, 2338 (1951); from isofuntumidine: Janot et al., Bull. Soc. Chim. Fr. 1960, 1669.

Murexide CAS Registry Number: 3051-09-0 紫脲酸铵

CAS Name: 5-[(Hexahydro-2,4,6-trioxo-5-pyrimidinyl)imino]-2,4,6(1H,3H,5H)-pyrimidinetrione monoammonium salt
Additional Names: 5,5'-nitrilodibarbituric acid monoammonium salt; acid ammonium pur...
Literature References: Prepn from alloxan + NH3: Hartley, J. Chem. Soc. 87, 1791 (1905); Schwartz, Handritschk, DD 17589 (1959), C.A. 55, 3630a (1961); from alloxantin + ammonium acetate: Davidson, J. Am. Chem. Soc. 58, 1821 (1936). Structure: Hartley, J. Chem. Soc. 87, 1796 (1905); Winslow, J. Am. Chem. Soc. 61, 2089 (1939); Schreiber, Mitt. Dtsch. Pharm. Ges. 28, 20 (1958).

Allyl Ether CAS Registry Number: 557-40-4 烯丙基醚

CAS Name: 3,3'-Oxybis-1-propene
Additional Names: diallyl ether
Percent Composition: C 73.43%, H 10.27%, O 16.30%
Literature References: Prepn from allyl alcohol in the presence of CuCl-H2SO4: Stephenson, GB 913919 (1962 to Monsanto); from allyl alcohol with K2CO3 and allyl bromide: Riemschneider, Kötzsch, Monatsh. Chem. 90, 787 (1959). Toxicity: H. F. Smyth et al., J. Ind. Hyg. Toxicol. 31, 60 (1949).

Ammonium Hexafluoroaluminate CAS Registry Number: 7784-19-2 氟铝酸铵

CAS Name: Triammonium hexafluoroaluminate(3-)
Additional Names: ammonium cryolite; ammonium aluminum fluoride; ammonium fluoaluminate
Percent Composition: Al 13.83%, F 58.43%, H 6.20%, N 21....
Literature References: Prepn from ammonium fluoride and aluminum hydroxide: v. Helmolt, Z. Anorg. Allg. Chem. 3, 127 (1893); Petersen, J. Prakt. Chem. [2] 40, 55 (1889); Kwasnik in Handbook of Preparative Inorganic Chemistry vol. 1, G. Brauer, Ed. (Academic Press, New York, 2nd ed. 1963) p 236.

N-(1-Naphthyl)ethylenediamine CAS Registry Number: 551-09-7 N-(萘-1-基)-1,2-乙二胺

CAS Name: N-1-Naphthalenyl-1,2-ethanediamine
Additional Names: 1-amino-2-(a-naphthylamino)ethane
Percent Composition: C 77.38%, H 7.58%, N 15.04%
Literature References: Prepn from a-naphthylamine and bromoethylphthalimide: Bratton, Marshall, J. Biol. Chem. 128, 537 (1939).

p-Anol CAS Registry Number: 539-12-8 4-[(1E)-1-丙烯-1-基]苯酚

CAS Name: 4-(1-Propenyl)phenol
Additional Names: p-propenylphenol; 4-hydroxy-1-propenylbenzene
Percent Composition: C 80.56%, H 7.51%, O 11.92%
Literature References: Prepn from anethole: Stoermer, Kahlert, Ber. 34, 1812 (1901); from 4-propenylphenylmagnesium bromide: Quelet, Bull. Chim. Soc. [4] 45, 268 (1929).

sym-Diphenylthiourea CAS Registry Number: 102-08-9 二苯基硫脲

CAS Name: N,N'-Diphenylthiourea
Additional Names: thiocarbanilide; sulfocarbanilide
Percent Composition: C 68.39%, H 5.30%, N 12.27%, S 14.04%
Literature References: Prepn from aniline and carbon disulfide: Fry, J. Am. Chem. Soc. 35, 1539 (1913); Stasse, US 2435295 (1948 to Allied Chem. Dye); from potassium ethylxanthate and aniline: Aravindakshan et al., Indian J. Chem. 1(9), 395 (1963). Physical properties and toxicity data: P. J. Hanzlik, A. Irvine, J. Pharmacol. Exp. Ther. 17, 349 (1921).