其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Dimethylcadmium CAS Registry Number: 506-82-1 高纯二甲基镉

Additional Names: Cadmium dimethyl
Percent Composition: C 16.86%, H 4.24%, Cd 78.90%
Literature References: Prepn from a Grignard reagent and a cadmium halide: Krause, Ber. 50, 1813 (1917); Gilman, Nelson, Rec. Trav. Chim. 55, 518 (1936); Anderson, Taylor, J. Phys. Chem. 56, 161 (1952).

Brompheniramine CAS Registry Number: 86-22-6 溴苯那敏

CAS Name: g-(4-Bromophenyl)-N,N-dimethyl-2-pyridinepropanamine
Additional Names: 2-[p-bromo-a-(2-dimethylaminoethyl)benzyl]pyridine; 1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane; 3-(p...
Literature References: Prepn from a-(p-bromophenyl)-a-(b-dimethylaminoethyl)-2-pyridylacetonitrile: Sperber et al., US 2567245 (1951); US 2676964 (1954 to Schering). Prepn of d-form: L. A. Walter, US 3061517 (1962 to Schering).

Dimethylacetal CAS Registry Number: 534-15-6 乙缩醛二甲醇

CAS Name: 1,1-Dimethoxyethane
Additional Names: acetaldehyde dimethyl acetal; ethylidene dimethyl ether
Percent Composition: C 53.31%, H 11.18%, O 35.51%
Literature References: Prepn from acetaldehyde and methanol: Meadows, Darwent, Can. J. Chem. 30, 501 (1952); Frevel, Hedelund, US 2691684 (1954 to Dow). Toxicity study: H. F. Smyth et al., J. Ind. Hyg. Toxicol. 31, 60 (1949).

p-Nitroaniline CAS Registry Number: 100-01-6 4-硝基苯胺

Additional Names: p-Nitraniline
Percent Composition: C 52.18%, H 4.38%, N 20.28%, O 23.17%
Literature References: Prepn from acetanilide: Bart, US 2406578 (1946 to Am. Cyanamid); by Schmidt reaction: Stockel, Hall, Nature 197, 787 (1963).

Propyl Acetate CAS Registry Number: 109-60-4 醋酸正丙酯

CAS Name: Acetic acid n-propyl ester
Percent Composition: C 58.80%, H 9.87%, O 31.33%
Literature References: Prepn from acetic acid and n-propyl alcohol: Wagner, J. Chem. Educ. 27, 245 (1950). Manuf from acetic acid and mixture of propene + propane in the presence of ZnCl2 catalyst: Biller, GB 872876 (1961). Toxicity study: P. M. Jenner et al., Food Cosmet. Toxicol. 2, 327 (1964).

Acetyl Nitrate CAS Registry Number: 591-09-3 硝酸乙酸酐

CAS Name: Acetic acid anhydride with nitric acid
Percent Composition: C 22.87%, H 2.88%, N 13.33%, O 60.92%
Literature References: Prepn from acetic anhydride and N2O5: Boh, Ann. Chim. [11] 20, 437 (1945).

Iodoform CAS Registry Number: 75-47-8 三碘甲烷

CAS Name: Triiodomethane
Percent Composition: C 3.05%, H 0.26%, I 96.69%
Literature References: Prepn from acetone, sodium hypochlorite, potassium iodide, and sodium hydroxide: Glass, Q. J. Pharm. Pharmacol. 8, 351 (1935); from chloroform + methyl iodide: Soroos, Hinkamp, J. Am. Chem. Soc. 67, 1642 (1945); by electrolysis: Glasstone, Ind. Chem. 7, 315 (1931). Description of the iodoform reaction: Seelye, Turney, J. Chem. Educ. 36, 572 (1959). Toxicity study: Kutob, Plaa, Toxicol. Appl. Pharmacol. 4, 354 (1962).

Kyanmethin CAS Registry Number: 461-98-3 4-氨基-2,6-二甲基嘧啶

CAS Name: 2,6-Dimethyl-4-pyrimidinamine
Additional Names: 4-amino-2,6-dimethylpyrimidine; 6-amino-2,4-dimethylpyrimidine
Percent Composition: C 58.51%, H 7.37%, N 34.12%
Literature References: Prepn from acetonitrile and potassium methoxide: Ronzio, Cook, Org. Synth. coll. vol. III, 71 (1955).

w -Bromoacetophenone CAS Registry Number: 70-11-1 2-溴苯乙酮

CAS Name: 2-Bromo-1-phenylethanone
Additional Names: phenacyl bromide
Percent Composition: C 48.27%, H 3.54%, Br 40.14%, O 8.04%
Literature References: Prepn from acetophenone and bromine: Rother, Reid, J. Am. Chem. Soc. 41, 77 (1919); Cowper, Davidson, Org. Synth. 19, 24 (1939); Shevchuk, Dombrovskii, Zh. Obshch. Khim. 33(4), 1135 (1963).

b -Amino- a -methylphenethyl Alcohol CAS Registry Number: 52500-61-5 1-氨基-1-苯基丙-2-醇

CAS Name: b-Amino-a-methylbenzeneethanol
Additional Names: 1-amino-1-phenyl-2-propanol; 1-phenyl-1-amino-2-propanol
Percent Composition: C 71.49%, H 8.67%, N 9.26%, O 10.58%
Literature References: Prepn from a-isonitroso-a-phenylacetone: Sichner, Pankova, Collect. Czech. Chem. Commun. 20, 1419 (1955); from an oxazole: Viscontini, Helv. Chim. Acta 44, 636 (1961).