其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Triclocarban CAS Registry Number: 101-20-2 三氯卡班

CAS Name: N-(4-Chlorophenyl)-N'-(3,4-dichlorophenyl)urea
Additional Names: 3,4,4'-trichlorocarbanilide; 1-(3',4'-dichlorophenyl)-3-(4'-chlorophenyl)urea; TCC
Trademarks: Cutisan (Boots); Nob...
Literature References: Prepn from 3,4-dichloroaniline and 4-chlorophenyl isocyanate: Beaver et al., J. Am. Chem. Soc. 79, 1236 (1957); Beaver, Stoffel, US 2818390 (1957 to Monsanto); GB 769273 (1957).

Clonitrate CAS Registry Number: 2612-33-1 氯硝甘油

CAS Name: 3-Chloro-1,2-propanediol dinitrate
Additional Names: 3-chloropropyleneglycol dinitrate; dinitrochlorohydrin
Trademarks: Dylate (Unimed)
Percent Composition: C 17.97%, H 2.51%, C...
Literature References: Prepn from 3-chloro-1,2-propanediol: Henry, Ann. 155, 165 (1870).

Levallorphan CAS Registry Number: 152-02-3 左洛啡烷

CAS Name: 17-(2-Propenyl)morphinan-3-ol
Additional Names: l,N-allyl-3-hydroxymorphinan; l-3-hydroxy-N-allylmorphinan
Percent Composition: C 80.52%, H 8.89%, N 4.94%, O 5.65%
Literature References: Prepn from 3-hydroxy-N-methylmorphinan: Schnider, Grüssner, Helv. Chim. Acta 34, 2211 (1951). Alternate route: Hellerbach et al., ibid. 39, 429 (1956). Comprehensive description: B. C. Rudy, B. Z. Senkowski, Anal. Profiles Drug Subs. 2, 339-361 (1973).

Alizarine Blue CAS Registry Number: 568-02-5 5-羟基-4H-萘并[2,3-f]喹啉-6,7,12-三酮

CAS Name: 5,6-Dihydroxynaphtho[2,3-f]quinoline-7,12-dione
Additional Names: 7,8-dihydroxy-5,6-phthalylquinoline; Alizarin Blue R; C.I. 67410
Percent Composition: C 70.10%, H 3.11%, N 4.81%, ...
Literature References: Prepn from 3-nitroalizarin, glycerol, and concd sulfuric acid: Auerbach, J. Chem. Soc. 35, 799 (1879); Colour Index vol. 4 (3rd ed., 1971) p 4567.

Lumazine CAS Registry Number: 487-21-8 2,4-二羟基蝶啶

CAS Name: 2,4(1H,3H)-Pteridinedione
Percent Composition: C 43.91%, H 2.46%, N 34.14%, O 19.50%
Literature References: Prepn from 4,5-diamino-2,6-dihydoxypyrimidine and glyoxal sodium bisulfate in the presence of ammonia: Weijlard et al., J. Am. Chem. Soc. 67, 804 (1945); US 2479442 (1950 to Merck Co.); from 5,6-diaminouracil hydrosulfite + ethylene glycol disulfonic acid disodium salt + HCl: Dallacker, Steiner, Ann. 660, 98 (1962).

Clioxanide CAS Registry Number: 14437-41-3 氯碘沙尼

CAS Name: 2-(Acetyloxy)-N-(4-chlorophenyl)-3,5-diiodobenzamide
Additional Names: 4'-chloro-3,5-diiodosalicylanilide acetate; acetoxy-4'-chloro-3,5-diiodobenzanilideTrademarks: Tremerad (Parke-D...
Literature References: Prepn from 4¢-chloro-3,5-diiodosalicylanilide: A. Campbell et al., Experientia 23, 992 (1967); NL 6604303 (1966 to Parke, Davis), C.A. 66, 55247d (1967), corresp to GB 1070516. Anthelmintic activity: Presidente et al., Am. J. Vet. Res. 33, 1593 (1972).

p-Bromophenylhydrazine CAS Registry Number: 589-21-9 4-溴苯基肼

Percent Composition: C 38.53%, H 3.77%, Br 42.72%, N 14.98%
Literature References: Prepn from 4-bromophenyldiazonium chloride by modified Fischer phenylhydrazine synthesis: Chattaway, Humphrey, J. Chem. Soc. 1927, 1323.

Chromotropic Acid CAS Registry Number: 148-25-4 1,8-二羟基萘-3,6-二磺酸

CAS Name: 4,5-Dihydroxy-2,7-naphthalenedisulfonic acid
Additional Names: 1,8-dihydroxynaphthalene-3,6-disulfonic acid
Percent Composition: C 37.50%, H 2.52%, O 39.96%, S 20.02%
Literature References: Prepn from 4-chloro-5-hydroxy-2,7-naphthalenedisulfonic acid: DE 147852 (1904 to BASF); alternate methods: Frdl. 3, 460-466.

Subathizone CAS Registry Number: 121-55-1 舒巴硫腙

CAS Name: 2-[[4-(Ethylsulfonyl)phenyl]methylene]hydrazinecarbothioamide
Additional Names: p-ethylsulfonylbenzaldehyde thiosemicarbazone; 4-ethylsulfonylbenzaldehyde 3-thiosemicarbazone
Trade...
Literature References: Prepn from 4-ethylsulfonyltoluene: Bernstein et al., J. Am. Chem. Soc. 73, 906 (1951); other prepns are described in JP 52 1119 (1952); US 2621484 (1952 to Schenley).

Nifurtimox CAS Registry Number: 23256-30-6 硝呋替莫

CAS Name: 3-Methyl-N-[(5-nitro-2-furanyl)methylene]-4-thiomorpholinamine 1,1-dioxide
Additional Names: 4-[(5-nitrofurfurylidene)amino]-3-methylthiomorpholine-1,1-dioxide; tetrahydro-3-methyl-4-...
Literature References: Prepn from 5-nitrofurfural and 4-amino-3-methyltetrahydro-1,4-thiazine 1,1-dioxide: Herlinger et al., DE 1170957 corresp to US 3262930 (1964 and 1966 to Bayer). Series of articles on pharmacology and clinical findings: Arzneim.-Forsch. 22, 1563-1642 (1972). Toxicity data: K. Hoffmann, ibid. 1590.