其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Helicin CAS Registry Number: 618-65-5 绣线菊苷

CAS Name: 2-(b-D-Glucopyranosyloxy)benzaldehyde
Additional Names: salicylaldehyde b-D-glucoside
Percent Composition: C 54.93%, H 5.67%, O 39.40%
Literature References: Prepn by the oxidation of salicin with dil nitric acid: Schiff, Ann. 154, 19 (1870); from salicylaldehyde + O-tetraacetyl-a-glucosidyl bromide: Robertson, Waters, J. Chem. Soc. 1930, 2729. ORD and stereochemical studies: Tsuzuki et al., Bull. Chem. Soc. Jpn. 44, 526 (1971).

Folescutol CAS Registry Number: 15687-22-6 七叶吗啉

CAS Name: 6,7-Dihydroxy-4-(4-morpholinylmethyl)-2H-1-benzopyran-2-one
Additional Names: 6,7-dihydroxy-4-(morpholinomethyl)coumarin; 4-morpholinomethylescutol; pholescutol
Percent Composition...
Literature References: Prepn by the reaction of 4-chloromethyl-6,7-dihydroxycoumarin with morpholine: FR M2035 (1963 to Labs. Dausse), C.A. 60, 4113 (1964). Pharmacological study: J. P. Tarayre et al., Ann. Pharm. Fr. 33, 467 (1975).

Bibenzyl CAS Registry Number: 103-29-7 1, 2-二苯乙烷

CAS Name: 1,1'-(1,2-Ethanediyl)bisbenzene
Additional Names: dibenzyl; sym-diphenylethane; 1,2-diphenylethane
Percent Composition: C 92.26%, H 7.74%
Literature References: Prepn by the reduction of benzil or benzoin: Clemmensen, Ber. 47, 688 (1914); Gattermann-Wieland, Praxis des Organischen Chemikers (de Gruyter, Berlin, 40th ed., 1961) p 333; from stilbene, Kleiderer, Kornfeld, J. Org. Chem. 13, 455 (1948).

Pyrazinoic Acid CAS Registry Number: 98-97-5 2-吡嗪羧酸

CAS Name: Pyrazinecarboxylic acid
Additional Names: pyrazinemonocarboxylic acid
Percent Composition: C 48.39%, H 3.25%, N 22.57%, O 25.78%
Literature References: Prepn by thermal decompn of 2,3-pyrazinedicarboxylic acid: Hall, Spoerri, J. Am. Chem. Soc. 62, 664 (1940); by oxidation of alkylpyrazines: Gainer, J. Org. Chem. 24, 691 (1959).

Benfluorex CAS Registry Number: 23602-78-0 苯氟雷司

CAS Name: 2-[[1-Methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amino]ethanol benzoate (ester)
Additional Names: 2-[[a-methyl-m-(trifluoromethyl)phenethyl]amino]ethanol benzoate (ester); 1-(m-trifluo...
Literature References: Prepn from 1-(m-trifluoromethyl)-2-(b-hydroxyethyl)aminopropane and benzoyl chloride: L. Beregi et al., FR 1517587; eidem, US 3607909 (1968, 1971 both to Sci. Union et Cie, Soc. Franc. Rech. Med.). Metabolism studies: A. H. Beckett et al., J. Pharm. Pharmacol. 23, 950 (1971); 24, 281 (1972). Pharmacology: D. N. Brindley et al., ibid. 28, 670 (1976); P. Pritchard et al., ibid. 29, 343 (1977); eidem, Biochem. J. 166, 639 (1977).

Alexidine CAS Registry Number: 22573-93-9 己联双辛胍

CAS Name: N,N''-Bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide
Additional Names: 1,1'-hexamethylenebis[5-(2-ethylhexyl)biguanide]Trademarks: Bisguadine (Sterwin)
Per...
Literature References: Prepn from 1,1¢-hexamethylenebis(3-cyanoguanide) and 2-ethylhexylamine hydrochloride: FR 1463818 (1965 to Sterling Drug). Evaluation as antimicrobial agent: McNamara et al., J. Soc. Cosmet. Chem. 16, 499 (1965).

Tetrahydrofuran CAS Registry Number: 109-99-9 四氢呋喃

Additional Names: Diethylene oxide; tetramethylene oxide
Percent Composition: C 66.62%, H 11.18%, O 22.19%
Literature References: Prepn from 1,4-butanediol: Schmoyer, Case, Nature 187, 592 (1960). Manuf by catalytic hydrogenation of maleic anhydride: Gilbert, Howk, US 2772293 (1956 to du Pont); of furan: Banford, Manes, US 2846449 (1958 to du Pont); Manly, US 3021342 (1962 to Quaker Oats). Stabilization to prevent excessive peroxide formation on storage with 0.05-1.0% p-cresol, 0.05-0.1% hydroquinone, or less than 0.01-0.1% 4,4¢-thiobis(6-tert-butyl-m-cresol): Bordner, Hinegardner, US 2489260; US 2525410; Campbell, US 3029257 (1949, 1950, 1962 all to du Pont). Review of toxicology and biological effects: D. E. Moody, Drug Chem. Toxicol. 14, 319-342 (1991).

Algestone CAS Registry Number: 595-77-7 双羟孕酮

CAS Name: (16a)-16,17-Dihydroxypregn-4-ene-3,20-dione
Additional Names: 16a,17-dihydroxyprogesterone; 4-pregnene-16a,17a-diol-3,20-dione; alphasone
Percent Composition: C 72.80%, H 8.73%, O ...
Literature References: Prepn from 16-dehydroprogesterone: Inhoffen et al., Ber. 87, 593 (1954); Cooley et al., J. Chem. Soc. 1955, 4373; Allen, Bernstein, J. Am. Chem. Soc. 78, 1909 (1956); Hydorn et al., Steroids 3, 493 (1964). Manuf from 16-dehydroprogesterone: Colton, US 2727909 (1955 to Searle); Hydorn et al., US 3165541 (1965 to Olin Mathieson); from its 16a-acetate: Diassi, US 3027384 (1962 to Olin Mathieson).

Quinbolone CAS Registry Number: 2487-63-0 (17b)-17-(1-环戊烯-1-基氧基)-雄甾-1,4-二烯-3-酮

CAS Name: (17b)-17-(1-Cyclopenten-1-yloxy)androsta-1,4-dien-3-one
Additional Names: 1-dehydrotestosterone 17-cyclopent-1'-enyl ether
Trademarks: Anabolicum Vister (Parke-Davis)
Percent Co...
Literature References: Prepn from 17b-hydroxyandrosta-1,4-dien-3-one: Ercoli et al., Chem. Ind. (London) 1962, 1284.

Nitrofurantoin CAS Registry Number: 67-20-9 呋喃妥因

CAS Name: 1-[[(5-Nitro-2-furanyl)methylene]amino]-2,4-imidazolidinedione
Additional Names: N-(5-nitro-2-furfurylidene)-1-aminohydantoin; 1-(5-nitro-2-furfurylideneamino)hydantoin
Trademarks:...
Literature References: Prepn from 1-aminohydantoin sulfate and 5-nitro-2-furaldehyde diacetate: K. J. Hayes, US 2610181 (1952 to Eaton Labs.); Swirska et al., Przem. Chem. 11 (34), 306 (1955), C.A. 52, 14079b (1958). Alternate routes: J. G. Michels, US 2898335; G. Gever, C. J. O'Keefe, US 2927110 (1959, 1960 both to Norwich Pharmacal). LC-MS/MS determn of residues in meat: P. Mottier et al., J. Chromatogr. A 1067, 85 (2005). Clinical trial in urinary tract infection: R. G. Rogers et al., Am. J. Obstet. Gynecol. 191, 182 (2004). Comprehensive description: D. E. Cadwallader, H. W. Jun, Anal. Profiles Drug Subs. 5, 345-373 (1976).