其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

p-Phenetidine CAS Registry Number: 156-43-4 对氨基苯乙醚

CAS Name: 4-Ethoxybenzenamine
Additional Names: 4-aminophenetole; 4-ethoxyaniline; p-aminophenyl ethyl ether
Percent Composition: C 70.04%, H 8.08%, N 10.21%, O 11.66%
Literature References: Prepn by reduction of p-nitrophenetole: West, J. Chem. Soc. 127, 494 (1925). Prepn from nitrobenzene, ethanol, Mg, and sulfuric acid: Yukawa, J. Chem. Soc. Jpn. 71, 547 (1950).

Dihydrotachysterol CAS Registry Number: 67-96-9 多沙唑嗪杂质F

CAS Name: (3b,5E,7E,10a,22E)-9,10-Secoergosta-5,7,22-trien-3-ol
Additional Names: dichystrolum; anti-tetany substance 10; AT 10
Trademarks: Antitanil; Calcamine (Wander); Dygratyl (Ferrosan)...
Literature References: Prepn by reduction of tachysterol: Windaus et al., Ann. 499, 198 (1932); v. Werder, US 2228491 (1941 to Winthrop), cf. Z. Physiol. Chem. 260, 119 (1939). Activity similar to parathyroid extract.

Cyproquinate CAS Registry Number: 19485-08-6 环丙喹酯

CAS Name: 6,7-Bis(cyclopropylmethoxy)-4-hydroxy-3-quinolinecarboxylic acid ethyl ester
Additional Names: ethyl 6,7-bis(cyclopropylmethoxy)-4-hydroxyquinoline-3-carboxylate; cyproquinidate; cypr...
Literature References: Prepn by ring closure of corresp dialkyl (alkoxyphenylamino)methylenemalonates: Mizzoni et al., Experientia 24, 1188 (1968); Mizzoni, DeStevens, ZA 6705655 (1968 to Ciba), C.A. 70, 47316t (1969). Review of structure and biology: Mizzoni et al., J. Med. Chem. 13, 870 (1970).

Cassella's Acid F CAS Registry Number: 494-44-0 7-氨基萘-2-磺酸

CAS Name: 7-Amino-2-naphthalenesulfonic acid
Additional Names: 2-naphthylamine-7-sulfonic acid; b-naphthylamine-d-sulfonic acid
Percent Composition: C 53.80%, H 4.06%, N 6.27%, O 21.50%, S 1...
Literature References: Prepn by sulfonation of b-naphthylamine and separation from the 6-amino isomer: Green, J. Chem. Soc. 55, 33 (1889); from 7-hydroxy-2-naphthalenesulfonic acid and ammonia: Green, loc. cit.; Wait, US 1492497 (1924).

Pyridoxal 5-Phosphate CAS Registry Number: 54-47-7 磷酸吡哆醛

CAS Name: 3-Hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde
Additional Names: pyridoxal 5-monophosphoric acid ester; 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-...
Literature References: Prepn by the action of adenosine triphosphate on pyridoxal: Gunsalus et al., J. Biol. Chem. 155, 685 (1944); by the action of phosphorus oxychloride on pyridoxal in aq soln: Gunsalus et al., ibid. 161, 743 (1945); Umbreit et al., Arch. Biochem. 7, 189 (1945); by phosphorylation of pyridoxamine with 100% H3PO4 followed by oxidation: Wilson, Harris, J. Am. Chem. Soc. 73, 4693 (1951). Alternate route: Schorre, US 3124587 (1964 to E. Merck). Isoln in pure form as the oxime and as the O-methyl oxime and structure: Heyl et al., J. Am. Chem. Soc. 73, 3430 (1951). Activity as a cotransaminase in the synthesis of amino acids: Lichstein et al., J. Biol. Chem. 161, 311 (1945). Activity of natural and synthetic material: Umbreit et al., loc. cit.

Vanadyl Trichloride CAS Registry Number: 7727-18-6 三氯氧钒

CAS Name: (T-4)-Trichlorooxovanadium
Additional Names: vanadium(V) trichloride oxide; vanadium oxytrichloride
Percent Composition: Cl 61.37%, O 9.23%, V 29.39%
Literature References: Prepn by the action of dry Cl2 on V2O3 or V2O5: Brown, Griffitts, Inorg. Synth. 1, 106 (1939); 4, 80 (1953); Oppermann, Z. Anorg. Allg. Chem. 351, 113 (1967). Toxicity data: Smyth et al., Am. Ind. Hyg. Assoc. J. 30, 470 (1969).

Tetrasilane CAS Registry Number: 7783-29-1 正四硅烷

Additional Names: Tetrasilicon decahydride; silicobutane; tetrasilicane; tetrasilicobutane
Percent Composition: H 8.23%, Si 91.77%
Literature References: Prepn by the action of hydrochloric acid on magnesium silicide: Stock, Somiesky, Ber. 49, 111 (1916); 54B, 524 (1921); 56B, 247 (1923); Stock et al., Ber. 56, 1695 (1923); Emeleus, Maddock, J. Chem. Soc. 1946, 1131.

L -Isoglutamine CAS Registry Number: 636-65-7 L-异谷氨酰胺

CAS Name: (4S)-4,5-Diamino-5-oxopentanoic acid
Additional Names: 4-amino-L-glutaramic acid; glutamic acid a-amide
Percent Composition: C 41.09%, H 6.90%, N 19.17%, O 32.84%
Literature References: Prepn by the action of NH3 on N-carbobenzyloxy-L-glutamic acid anhydride: Kozo Narita, J. Chem. Soc. Jpn. Pure Chem. Sect. 74, 832 (1953); from 1-tosylpyroglutamide by reduction with Na in NH3: Swan, du Vigneaud, J. Am. Chem. Soc. 76, 3110 (1954); from the g-methyl ester of N-tritylglutamic acid: Amiard, Heymes, US 2927118 (1960 to UCLAF).

Cinnamoyl Chloride CAS Registry Number: 102-92-1 β-苯基丙烯酰氯

CAS Name: 3-Phenyl-2-propenoyl chloride
Percent Composition: C 64.88%, H 4.24%, Cl 21.28%, O 9.60%
Literature References: Prepn by the action of oxalyl chloride on sodium cinnamate: Adams, Ulich, J. Am. Chem. Soc. 42, 605 (1920).

Formyl Fluoride CAS Registry Number: 1493-02-3

Percent Composition: C 25.01%, H 2.10%, F 39.56%, O 33.32%
Literature References: Prepn by the interaction of anhydr formic acid, potassium fluoride and benzoyl chloride (16% yield): Nyesmejanov, Kahn, Ber. 67, 203 (1946); from benzoyl fluoride and formic acid (36% yield): Masentshev, J. Gen. Chem. USSR 16, 203 (1946); from benzoyl chloride, formic acid, and KHF2 (35% yield): Olah et al., Ber. 89, 862 (1956); Olah, Kuhn, J. Am. Chem. Soc. 82, 2381 (1960); from acetic formic anhydride, CH3COOOCH, and anhydr HF (67% yield): Olah, Kuhn, ibid. 2380.