其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Naphthoresorcinol CAS Registry Number: 132-86-5 间萘二酚

CAS Name: 1,3-Naphthalenediol
Additional Names: 1,3-dihydroxynaphthalene
Percent Composition: C 74.99%, H 5.03%, O 19.98%
Literature References: Prepn by cyclization of ethyl phenylacetoacetate: Soliman, West, J. Chem. Soc. 1944, 53; by heating 1-amino-3-hydroxy-4-naphthalenesulfonic acid in acidic soln: Meyer, Bloch, Org. Synth. 25, 73 (1945); from 1,3-naphtholsulfonic acid: Kozlov, Odintsov, J. Appl. Chem. (USSR) 17, 219 (1944); Kozlov et al., Zh. Prikl. Khim. 35, 880 (1962).

Hemi-Dewar Biphenyl CAS Registry Number: 4655-30-5

CAS Name: 2-Phenylbicyclo[2.2.0]hexa-2,5-diene
Percent Composition: C 93.46%, H 6.54%
Literature References: Prepn by decompn of cyclobutadieneiron tricarbonyl with ceric ammonium nitrate in the presence of phenylacetylene: Burt, Pettit, Chem. Commun. 1965, 517.

p-Diazobenzenesulfonic Acid CAS Registry Number: 305-80-6 重氮苯磺酸

CAS Name: 4-Sulfobenzenediazonium inner salt
Additional Names: DABS; diazotized sulfanilic acid ; Pauly's reagent; sulfanilic acid diazonium salt
Percent Composition: C 39.13%, H 2.19%, N 15...
Literature References: Prepn by diazotization of sulfanilic acid: E. Fischer, Ann. 190, 67 (1878); K. B. Whetsel et al., J. Am. Chem. Soc. 78, 3360 (1956); G. Kaupp et al., Chem. Eur. J. 8, 1395 (2002). Crystal structure.: C. Bugg et al., Acta Crystallogr. 17, 767 (1964). Use as denaturant for membrane proteins: R. T. Giaquinta et al., Arch. Biochem. Biophys. 162, 200 (1974); M.-J. Bouchet et al., J. Med. Chem. 30, 2222 (1987); of protein components: S. K. Nishimoto et al., Anal. Biochem. 216, 156 (1994). Determn of bilirubin: J. B. Landis, H. L. Pardue, Clin. Chem. 24, 1690 (1978); P. Fossati et al., ibid. 35, 173 (1989); of phenols: C. Baiocchi et al., Anal. Lett. 15, 1539 (1982); M. C. Quintero et al., Talanta 36, 717 (1989); of halides: M. Pandey et al., Analyst 123, 2319 (1998); S. Gosain et al., J. AOAC Int. 82, 167 (1999).

Isatide CAS Registry Number: 464-73-3 3,3'-二羟基-1,1',3,3'-四氢-2H,2'H-3,3'-联吲哚-2,2'-二酮

CAS Name: 1,1',3,3'-Tetrahydro-3,3'-dihydroxy-[3,3'-bi-2H-indole]-2,2'-dione
Additional Names: 3,3'-dihydroxy-[3,3'-biindoline]-2,2'-dione; 3,3'-dihydroxy-3,3'-dihydroisoindigo; isatyde
Perc...
Literature References: Prepn by dimerization reduction of isatin with ammonium hydrosulfide: Laurent, Ann. Chim. 3, 372 (1841); by piperidine-catalyzed condensation of isatin and dioxindole: Heller, Ber. 37, 943 (1904); Wahl, Hansen, Compt. Rend. 178, 393 (1924); from isatin and acenaphthene in sunlight: Oliveri-Mandala, Deleo, Gazz. Chim. Ital. 79, 337 (1949). Structure: Lefèvre, Bull. Soc. Chim. Fr. 19, 113 (1916); Sumpter, J. Am. Chem. Soc. 54, 2917 (1932); Bergmann, ibid. 77, 1549 (1955).

Thioacetic Acid CAS Registry Number: 507-09-5 硫代乙酸

CAS Name: Ethanethioic acid
Additional Names: thiolacetic acid; thiacetic acid
Percent Composition: C 31.56%, H 5.30%, O 21.02%, S 42.12%
Literature References: Prepn by distilling glacial acetic acid with phosphorus pentasulfide: Kekulé, Ann. 90, 309 (1854); from acetic anhydride and hydrogen sulfide: Ellingboe, Org. Synth. 31, 105 (1951).

Quatrimycin CAS Registry Number: 79-85-6 4-表四环素

CAS Name: [4R-(4a,4ab,5ab,6a,12ab)]-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
Additional Names: epitetracycline Literature References: Prepn by epimerization of tetracycline: McCormick et al., J. Am. Chem. Soc. 79, 2849 (1957); Kaplan et al., Antibiot. Chemother. 7, 569 (1957); Remmers et al., J. Pharm. Sci. 52, 752 (1963). Acute toxicity: L. Kung, H. Sun, Yao Hsueh Hsueh Pao 13, 244 (1966), C.A. 65, 7869e (1966).

Enflurane CAS Registry Number: 13838-16-9 2-氯-1-(二氟甲氧基)-1,1,2-三氟乙烷

CAS Name: 2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane
Additional Names: 2-chloro-1,1,2-trifluoroethyl difluoromethyl ether; methylfluretherTrademarks: Alyrane (Baxter); Efrane (Abbott); ...
Literature References: Prepn by fluorination of the corresp dichloromethyl ether: R. C. Terrell, GB 1138406; idem, US 3469011; US 3527813 (1969, 1969, 1970 all to Air Reduction). Synthesis and anesthetic properties: R. C. Terrell et al., J. Med. Chem. 14, 517 (1971); 15, 604 (1972). Enantiomeric resolution: J. Meinwald et al., Science 251, 560 (1991).

Tetraphosphorus Trisulfide CAS Registry Number: 1314-85-8 三硫化磷

Additional Names: Phosphorus sesquisulfide; trisulfurated phosphorus
Percent Composition: P 56.29%, S 43.71%
Literature References: Prepn by fusing red phosphorus with sulfur: Stock, Ber. 43, 150 (1910); also from white phosphorus and sulfur in a high-boiling solvent such as a-chloronaphthalene: Frary, DE 309618 (1918); Chem. Zentralbl. 1919, II, 55.

Chrysamminic Acid CAS Registry Number: 517-92-0 1,8-二羟基-2,4,5,7-四硝基蒽醌

CAS Name: 1,8-Dihydroxy-2,4,5,7-tetranitro-9,10-anthracenedione
Additional Names: 1,8-dihydroxy-2,4,5,7-tetranitroanthraquinone; 2,4,5,7-tetranitrochrysazin; chrysammic acid
Percent Composit...
Literature References: Prepn by heating chrysazin with fuming nitric acid: Liebermann, Ann. 183, 193 (1876). Structure: Robinson, Simonsen, J. Chem. Soc. 95, 1088 (1909).

N,N-Dimethyl-1-naphthylamine CAS Registry Number: 86-56-6 N,N-二甲基-1-萘胺

CAS Name: N,N-Dimethyl-1-naphthalenamine
Additional Names: 1-dimethylaminonaphthalene
Percent Composition: C 84.17%, H 7.65%, N 8.18%
Literature References: Prepn by heating in a closed tube 1-naphthylamine and methyl iodide in methyl alcohol: Landshoff, Ber. 11, 643 (1878); by heating 1-naphthylamine with dimethyl sulfate in sodium hydroxide in presence of pyridine: Germuth, J. Am. Chem. Soc. 51, 1556 (1929). Use: F. G. Germuth, Ind. Eng. Chem. Anal. Ed. 1, 28 (1929).