其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Scillarenin CAS Registry Number: 465-22-5 海葱苷元

CAS Name: (3b)-3,14-Dihydroxybufa-4,20,22-trienolide
Percent Composition: C 74.97%, H 8.39%, O 16.64%
Literature References: Prepn by adaptive enzymic decompn of proscillaridin A: Stoll et al., Helv. Chim. Acta 34, 2301 (1951); from Urginea burkei Baker, Liliaceae: Zoller, Tamm, ibid. 36, 1744 (1953). Structure: Stoll et al., ibid. 35, 1934 (1952). Toxicity study: Chen, Henderson, J. Pharmacol. Exp. Ther. 111, 365 (1954).

L -Erythrulose CAS Registry Number: 533-50-6 L-赤藓酮糖

CAS Name: (3S)-1,3,4-Trihydroxy-2-butanone
Additional Names: L-glycero-tetrulose
Percent Composition: C 40.00%, H 6.71%, O 53.29%
Literature References: Prepn by bacterial oxidation of meso-erythritol: Müller et al., Helv. Chim. Acta 20, 1468 (1937); Whistler, Underköfler, J. Am. Chem. Soc. 60, 2507 (1937). Synthesis from D-fructose: Gorin et al., J. Chem. Soc. 1955, 2699.

m-Nitrophenol CAS Registry Number: 554-84-7 3-硝基苯酚

Additional Names: 3-Nitrophenol
Percent Composition: C 51.80%, H 3.62%, N 10.07%, O 34.50%
Literature References: Prepn by boiling diazotized m-nitroaniline with water and H2SO4: Adams, Wilson, Org. Synth. 3, 87 (1923); Bachmann, Rottschaefer, ibid. 18, 88 (1938); Manske, ibid. coll. vol. I, 404 (2nd ed., 1941).

Broxyquinoline CAS Registry Number: 521-74-4 溴羟喹啉

CAS Name: 5,7-Dibromo-8-quinolinol
Additional Names: 5,7-dibromo-8-hydroxyquinoline
Trademarks: Brodiar (Intervet); Broxykinolin; Colepur (Draco); Fenilor (UCB); Intensopan (Sandoz)
Perce...
Literature References: Prepn by bromination of 5-formyl-8-quinolinol: Matsumura, Ito, J. Am. Chem. Soc. 77, 6671 (1955); by bromination of 8-hydroxyquinaldine: Irving, Pinnington, J. Chem. Soc. 1957, 285; by bromination of 8-quinolinol: Luis, Palomo, Afinidad 28, 163 (1951), C.A. 47, 10533d (1953); Zinnei, Fiedler, Arch. Pharm. 291, 493 (1958); Aristov, Kostina, Zh. Obshch. Khim. 34, 3421 (1964). Crystal structure: Kashino, Haisa, Bull. Chem. Soc. Jpn. 46, 1094 (1973). Metabolism: Rodriguez, Close, Biochem. Pharmacol. 17, 1647 (1968).

a -Butylene Dibromide CAS Registry Number: 533-98-2 1,2-二溴丁烷

CAS Name: 1,2-Dibromobutane
Percent Composition: C 22.25%, H 3.73%, Br 74.02%
Literature References: Prepn by bromination of butene: Wurtz, Ann. 152, 21 (1869); of bromobutane: Kharasch et al., J. Org. Chem. 20, 1430 (1955).

Norethandrolone CAS Registry Number: 52-78-8 诺乙雄龙

CAS Name: (17a)-17-Hydroxy-19-norpregn-4-en-3-one
Additional Names: 17a-ethyl-19-nortestosterone; 17a-ethyl-17-hydroxy-4-norandrosten-3-one; 17a-ethyl-17-hydroxy-19-norandrost-4-en-3-one
Tra...
Literature References: Prepn by catalytic hydrogenation of 17a-ethynyl-19-nortestosterone: Colton, US 2721871 (1955 to Searle); J. Am. Chem. Soc. 79, 1123 (1957).

Tetrahydrofurfuryl Alcohol CAS Registry Number: 97-99-4 四氢糠醇

CAS Name: Tetrahydro-2-furanmethanol
Additional Names: tetrahydro-2-furancarbinol; tetrahydro-2-furylmethanol; THFA
Percent Composition: C 58.80%, H 9.87%, O 31.33%
Literature References: Prepn by catalytic hydrogenation of furfuryl alcohol: Lukes, Nelson, J. Org. Chem. 21, 1096 (1956). Manuf by catalytic hydrogenation of furfural or furfuryl alcohol: Dunlop, Schegulla, US 2838523 (1958 to Quaker Oats). Occurs in two isomeric forms: D-isomer (levorotatory), L-isomer (dextrorotatory). Abs config: Gagnaire, Butt, Bull. Soc. Chim. Fr. 1961, 312; Hartman, Barker, J. Org. Chem. 29, 873 (1964). Review: A. P. Dunlop, F. N. Peters, The Furans (Reinhold, New York, 1953).

p-Chlorobenzoic Acid CAS Registry Number: 74-11-3 对氯苯甲酸

CAS Name: 4-Chlorobenzoic acid
Additional Names: chlorodracylic acid
Percent Composition: C 53.70%, H 3.22%, Cl 22.64%, O 20.44%
Literature References: Prepn by catalytic oxidation of 1-chloro-4-ethylbenzene: Emerson et al., J. Am. Chem. Soc. 71, 1742 (1949). Manuf by oxidation of p-chlorobenzaldehyde: Shipman, US 3124611 (1964 to ICI). Crystal structure: Toussaint, Acta Crystallogr. 4, 71 (1951), C.A. 45, 6604e (1951); Pollock, Woodward, ibid. 7, 605 (1954), C.A. 48, 13331e (1954).

Trichloroacetaldehyde CAS Registry Number: 75-87-6 三氯乙醛

Additional Names: Chloral; anhydr chloral
Percent Composition: C 16.30%, H 0.68%, Cl 72.16%, O 10.86%
Literature References: Prepn by chlorinating alcohol, treating with H2SO4 and then distilling: Liebig, Ann. 1, 189 (1832); Personne, J. Pharm. Chim. [4] 10, 350 (1869); 11, 205 (1870); Brochet, Bull. Soc. Chim. Fr. [3] 17, 228 (1897); Ann. Chim. [7] 10, 332 (1897); Trillat, Bull. Soc. Chim. Fr. [3] 17, 230 (1897); Besson, DE 133021 (1902); Chem. Zentralbl. 1902, II, 553; Ohse, DE 734723 (1943), C.A. 38, 3671 (1944). Prepn by chlorination of a mixture of alcohol and acetaldehyde: Société d'Electrochimie, FR 612396; Chim. Ind. (Paris) 21, 567 (1929). Prepn from chloral hydrate by azeotropic distn: Mahoney, Pierson, US 2584036 (1952 to Merck Co.). From hypochlorous acid and trichloroethylene: Stevens et al., US 2759978 (1956 to Columbia-Southern). In the laboratory anhydr chloral may be quickly obtained by shaking pharmaceutical grade chloral hydrate with concd H2SO4, separating the two layers, and distilling: cf. Gattermann, Wieland, Praxis des Organischen Chemikers (de Gruyter, Berlin, 40th ed., 1961) p 334. See also Chloral Hydrate.

Fenticlor CAS Registry Number: 97-24-5 双(2-羟基-5-氯苯基)硫醚

CAS Name: 2,2'-Thiobis[4-chlorophenol]
Additional Names: bis[2-hydroxy-5-chlorophenyl]sulfide; 2,2'-dihydroxy-5,5'-dichlorodiphenyl sulfideTrademarks: Novex
Percent Composition: C 50.19%, H ...
Literature References: Prepn by chlorination of bis[2-hydroxyphenyl]sulfide: Muth, DE 568944 (1931 to I. G. Farben); Dunning et al., J. Am. Chem. Soc. 53, 3466 (1931).