其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Ammonium Molybdate(VI) CAS Registry Number: 12027-67-7 七钼酸铵

CAS Name: Hexaammonium molybdate (Mo7O246-)
Additional Names: ammonium paramolybdate
Percent Composition: H 2.08%, Mo 57.71%, N 7.22%, O 32.99%
Literature References: Prepn and structure: Guiter, Compt. Rend. 220, 146 (1945); Lindqvist, Acta Chem. Scand. 2, 88 (1948). Toxicity studies: L. T. Fairhall et al., "The Toxicity of Molybdenum," U.S. Public Health Service Bulletin No. 293, Washington D.C. (1945) 39 pp.

Aceglatone CAS Registry Number: 642-83-1 醋葡醛内酯

CAS Name: D-Glucaric acid di-g-lactone diacetate
Additional Names: 2,5-di-O-acetyl-D-glucaro-1,4:6,3-dilactone; 2,5-di-O-acetyl-D-glucosaccharo-1,4:6,3-dilactone
Trademarks: Glucaron (Chugai...
Literature References: Prepn and structure: Hirasaka, Umemoto, Chem. Pharm. Bull. 13, 325 (1965), C.A. 63, 3024h (1965); Ishidate et al., JP 67 14956 (1967 to Tokyo Biochem. Res. Com.), C.A. 68, 78558m (1968). Pharmacological studies: Iida et al., Jpn. J. Pharmacol. 15, 88 (1965), C.A. 63, 5961g (1965).

Lead Hydroxide CAS Registry Number: 1311-11-1

Additional Names: Lead oxide hydrate; basic lead hydroxide
Percent Composition: H 0.42%, O 13.32%, Pb 86.26%
Literature References: Prepn and structure: Oswald et al., Helv. Chim. Acta 51, 1389 (1968).

Pyridofylline CAS Registry Number: 53403-97-7 吡哆茶碱

CAS Name: 3,7-Dihydro-1,3-dimethyl-7-[2-(sulfooxy)ethyl]-1H-purine-2,6-dione compd with 5-hydroxy-6-methyl-3,4-pyridinedimethanol (1:1)
Additional Names: 7-(2-hydroxyethyl)theophylline hydrogen...
Literature References: Prepn and therapeutic properties: A. Debarge, FR M828 (1961), C.A. 58, 9098g (1963).

Meticrane CAS Registry Number: 1084-65-7 美替克仑

CAS Name: 3,4-Dihydro-6-methyl-2H-1-benzothiopyran-7-sulfonamide 1,1-dioxide
Additional Names: 6-methylthiochroman-7-sulfonamide 1,1-dioxide; 6-methyl-7-sulfamoylthiochroman 1,1-dioxide
Trad...
Literature References: Prepn and use as diuretic: Boissier, Malen, FR M2790 and FR 1365504 (1962, 1963 to Soc. Ind. Fabric. Antibiot.).

Azanidazole CAS Registry Number: 62973-76-6 嘧啶硝唑

CAS Name: (E)-4-[2-(1-Methyl-5-nitro-1H-imidazol-2-yl)ethenyl]-2-pyrimidinamine
Additional Names: (E)-2-amino-4-[2-(1-methyl-5-nitroimidazol-2-yl)vinyl]pyrimidine; nitromidineTrademarks: Triclo...
Literature References: Prepn and use: A. Garzia, DE 2358483; eidem, US 3882105; US 3969520 (1974, 1975, 1976 all to Chemoterapico). Toxicological and teratological studies: R. Tammiso et al., Arzneim.-Forsch. 28, 2251 (1978).

p-Acetanisidine CAS Registry Number: 51-66-1 4'-甲氧基乙酰苯胺

CAS Name: N-(4-Methoxyphenyl)acetamide
Additional Names: p-acetanisidide; methacetin; p-methoxyacetanilide
Percent Composition: C 65.44%, H 6.71%, N 8.48%, O 19.37%
Literature References: Prepn by acetylation of p-anisidine: Reverdin, Bucky, Ber. 39, 2679 (1906); from p-acetylanisole and hydroxylamine-O-sulfonic acid: Sanford et al., J. Am. Chem. Soc. 67, 1941 (1945).

Proscillaridin CAS Registry Number: 466-06-8 原海葱甙A

CAS Name: (3b)-3-[(6-Deoxy-a-L-mannopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolide
Additional Names: 14-hydroxy-3b-(rhamnosyloxy)bufa-4,20,22-trienolide; 3b-rhamnosido-14b-hydroxy-D4,20,22-bu...
Literature References: Prepn by acid cleavage of scillaren A: Stoll et al., Helv. Chim. Acta 16, 703 (1933); by enzymic decompn of glucoscillaren A with strophanthobiase: Stoll et al., ibid. 35, 2495 (1952); from Urginea burkei Baker, Liliaceae: Zoller, Tamm, ibid. 36, 1744 (1953); from U. (Scilla) maritima (L.) Baker, Liliaceae: Görlich, Arzneim.-Forsch. 10, 770 (1960). Structure: Stoll et al., Helv. Chim. Acta 35, 1934 (1952). Pharmacology: Lenke, Brock, Arzneim.-Forsch. 20, 1 (1970). Metabolic studies: Davis et al., Arch. Int. Pharmacodyn. 177, 231 (1969); Nakano et al., ibid. 183, 199 (1970). Clinical studies: Several authors, Minerva Med. 58, 4243-4322 (1967). Toxicity study: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971). Series of articles on prepn, pharmacology, toxicology, pharmacokinetics, metabolism of 4¢-methyl ether: Arzneim.-Forsch. 28, 493-573 (1978).

Mevaldic Acid CAS Registry Number: 541-07-1 3-羟基-3-甲基戊二醛酸

CAS Name: 3-Hydroxy-3-methyl-5-oxopentanoic acid
Additional Names: 3-hydroxy-3-methylglutaraldehydic acid
Percent Composition: C 49.31%, H 6.90%, O 43.79%
Literature References: Prepn by acid hydrolysis of 3-hydroxy-3-methyl-5,5-dimethoxypentanoic acid: Shunk et al., J. Am. Chem. Soc. 79, 3294 (1957). Exists in equilibrium with b,d-dihydroxy-b-methyl-d-valerolactone.

Carbobenzoxy Chloride CAS Registry Number: 501-53-1 氯甲酸苄酯

CAS Name: Carbonochloridic acid phenylmethyl ester
Additional Names: benzyl chloroformate; chloroformic acid benzyl ester; benzylcarbonyl chloride
Percent Composition: C 56.33%, H 4.14%, Cl ...
Literature References: Prepn by action of phosgene absorbed in toluene on benzyl alcohol: Carter et al., Org. Synth. 23, 13 (1943); by reacting carbonyl chloride and benzyl alcohol at -20 to -30°: Farthing, J. Chem. Soc. 1950, 3213.