其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Chloroacetaldehyde CAS Registry Number: 107-20-0 一氯乙醛

Additional Names: 2-Chloro-1-ethanal; monochloroacetaldehyde
Percent Composition: C 30.60%, H 3.85%, Cl 45.16%, O 20.38%
Literature References: Prepd industrially by carefully controlled chlorination of acetaldehyde: Söll, DE 844595 (1943 to Knapsack-Griesheim); Shawinigan Chem. Ltd., GB 644914 (1947); Guinot, Tabuteau, Compt. Rend. 231, 234 (1950); FR 1012991 (1950 to Comp. des Prod. Chim. et Electrometallurg.).

Potassium Bisulfide CAS Registry Number: 1310-61-8 硫化氢钾,无水

Additional Names: Potassium hydrosulfide; potassium hydrogen sulfide; potassium sulfhydrate
Percent Composition: H 1.40%, K 54.18%, S 44.43%
Literature References: Prepd industrially from Ca(HS)2 and K2SO4: Hene, DE 380385 (1922); from H2S and K2S: Bassett, US 1662735 (1925); Strosacker, Jones, US 1771384 (1926 to Dow). Prepn of pure material by the action of dry H2S upon potassium metal dissolved in abs ethanol: Rule, J. Chem. Soc. 99, 558, 564 (1911); West, Z. Kristallogr. 88, 102 (1934).

Dimethyl Phthalate CAS Registry Number: 131-11-3 邻苯二甲酸二甲酯; 避蚊酯

CAS Name: 1,2-Benzenedicarboxylic acid dimethyl ester
Additional Names: phthalic acid dimethyl ester; methyl phthalate; dimethyl 1,2-benzenedicarboxylate; DMP
Trademarks: Palatinol M; Fermin...
Literature References: Prepd industrially from phthalic anhydride and methanol: Faith, Keyes Clark's Industrial Chemicals, F. A. Lowenheim, M. K. Moran, Eds. (Wiley-Interscience, New York, 4th ed., 1975) pp 318-324. Metabolite of Gibberella fujikuroi: Cross et al., J. Chem. Soc. 1963, 2937. Toxicity data: J. H. Draize et al., J. Pharmacol. Exp. Ther. 93, 26 (1948).

Ethanolamine CAS Registry Number: 141-43-5 2-氨基乙醇

CAS Name: 2-Aminoethanol
Additional Names: monoethanolamine; b-aminoethyl alcohol; 2-hydroxyethylamine; b-hydroxyethylamine; ethylolamine; colamine
Percent Composition: C 39.33%, H 11.55%, N...
Literature References: Prepd on a large scale by ammonolysis of ethylene oxide: Knorr, Ber. 30, 909 (1897); FR 650574 (1928 to I. G. Farben); Reid, Lewis, US 1904013 (1933 to Carbide Carbon); Schwoegler, Olin, US 2373199 (1945 to Sharples). Also from nitromethane and formaldehyde: Ullmanns Encyklopädie der technischen Chemie 3, 102 (3rd ed., 1953). Manuf: Faith, Keyes Clark's Industrial Chemicals, F. A. Lowenheim, M. K. Moran, Eds. (Wiley-Interscience, New York, 4th ed., 1975) pp 339-344. Toxicity: H. F. Smyth et al., J. Ind. Hyg. Toxicol. 23, 259 (1941).

Neophyl Chloride CAS Registry Number: 515-40-2 氯代叔丁基苯

CAS Name: (2-Chloro-1,1-dimethylethyl)benzene
Additional Names: 1-chloro-2-methyl-2-phenylpropane; (b-chloro-tert-butyl)benzene
Percent Composition: C 71.21%, H 7.77%, Cl 21.02%
Literature References: Prepn (68% yield) from benzene and methallyl chloride in the presence of concd sulfuric acid: Whitmore et al., J. Am. Chem. Soc. 65, 1469 (1943); Smith, Sellas, Org. Synth. coll. vol. IV, 702 (1963).

Cambendazole CAS Registry Number: 26097-80-3 坎苯达唑

CAS Name: [2-(4-Thiazolyl)-1H-benzimidazol-5-yl]carbamic acid 1-methylethyl ester
Additional Names: 2-(4-thiazolyl)-5-benzimidazolecarbamate isopropyl ester; 5-isopropoxycarbonylamino-2-(4-thia...
Literature References: Prepn and activity studies: Hoff, Fisher, ZA 6800351 (1969 to Merck Co.), C.A. 72, 90461q (1970); Hoff et al., Experientia 26, 550 (1970). Clinical studies with sheep, cattle and swine: Egerton et al., Res. Vet. Sci. 11, 193, 495, 590 (1970).

Desonide CAS Registry Number: 638-94-8 地索奈德

CAS Name: (11b,16a)-11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
Additional Names: 11b,16a,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal w...
Literature References: Prepn and activity: Bernstein et al., J. Am. Chem. Soc. 81, 4573 (1959); Bernstein, Allen, US 2990401 (1961 to Am. Cyanamid); Lee et al. and Diassi, Principe, US 3536586 and US 3549498 (both 1970 to Squibb). Pharmacological and toxicological studies: Mascitelli-Coriandoli, Fraia, Arzneim.-Forsch. 20, 111 (1970); Phillips et al., Toxicol. Appl. Pharmacol. 20, 522 (1971). Structure-activity studies: Ringler et al., Proc. Soc. Exp. Biol. Med. 107, 451 (1961). Chemical and physical properties: Mantica et al., Arzneim.-Forsch. 20, 109 (1970).

Acephate CAS Registry Number: 30560-19-1 乙酰甲胺磷

CAS Name: Acetylphosphoramidothioic acid O,S-dimethyl esterTrademarks: Orthene (Valent)
Percent Composition: C 26.23%, H 5.50%, N 7.65%, O 26.20%, P 16.91%, S 17.51%
Literature References: Prepn and activity: Magee, US 3716600 and US 3845172 (1973, 1974 both to Chevron).

Xenazoic Acid CAS Registry Number: 1174-11-4 珍那佐酸

CAS Name: 4-[(2-[1,1'-Biphenyl]-4-yl-1-ethoxy-2-oxoethyl)amino]benzoic acid
Additional Names: p-[(a-ethoxy-p-phenylphenacyl)amino]benzoic acid; p-[N-(a-ethoxy-b-keto-b-para-biphenyl)ethylamino]...
Literature References: Prepn and antiviral activity: Cavallini et al., J. Med. Pharm. Chem. 2, 99 (1960).

Ammonium Phosphomolybdate CAS Registry Number: 12026-66-3 磷钼酸铵

CAS Name: Ammonium molybdophosphate
Percent Composition: H 0.64%, Mo 61.36%, N 2.24%, O 34.11%, P 1.65%
Literature References: Prepn and constitution: Illingworth, Keggin, J. Chem. Soc. 1935, 575; Thistlewaite, Analyst 72, 531 (1947); Healy, Radiochim. Acta 3, 100 (1964).