其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Cyclethrin CAS Registry Number: 97-11-0 环虫菊酯

CAS Name: 2,2-Dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylic acid 3-(2-cyclopenten-1-yl)-2-methyl-4-oxo-2-cyclopenten-1-yl ester
Additional Names: 3-(2-cyclopentenyl)-2-methyl-4-oxo-2-c...
Literature References: Prepn and insecticidal activity: H. L. Haynes et al., Contrib. Boyce Thompson Inst. 18, 1 (1954); H. R. Guest, H. A. Stansbury, US 2891888 (1959 to Union Carbide). Product is a mixture of isomers including four racemic forms or eight optical and geometric isomers which have not yet been isolated and evaluated. Toxicology: C. P. Carpenter et al., Arch. Ind. Hyg. Occup. Med. 10, 162 (1954).

Clobenzorex CAS Registry Number: 13364-32-4 氯苄雷司

CAS Name: (+)-N-[(2-Chlorophenyl)methyl]-a-methylbenzeneethanamine
Additional Names: (+)-N-(o-chlorobenzyl)-a-methylphenethylamine; d-N-(1-phenyl-2-propyl)-2-chlorobenzylamine
Percent Compos...
Literature References: Prepn and pharmacology: J. R. Boissier, R. Ratouis, FR 1429306 (1966 to Soc. Ind. Fabric. Antibiot.), C.A. 66, 46195h (1967); J. R. Boissier et al., Ann. Pharm. Fr. 24, 57 (1966). Synthesis of labelled compound: J. Lintermans et al., J. Labelled Compd. 6, 289 (1970). Metabolic studies: M. Thomasset et al., Experientia 26, 692 (1970); B. Glasson et al., Arzneim.-Forsch. 21, 1985 (1971).

Ifenprodil CAS Registry Number: 23210-56-2 艾芬地尔

CAS Name: a-(4-Hydroxyphenyl)-b-methyl-4-(phenylmethyl)-1-piperidineethanol
Additional Names: 4-benzyl-a-(p-hydroxyphenyl)-b-methyl-1-piperidineethanol; 2-(4-benzylpiperidino)-1-(4-hydroxypheny...
Literature References: Prepn and pharmacology: M. Carron et al., FR M5733; US 3509164 (1968, 1970 to Robert et Carrière); C. Carron et al., Arzneim.-Forsch. 21, 1992 (1971).

Betoxycaine CAS Registry Number: 3818-62-0 异丁氧乙氧普卡因

CAS Name: 3-Amino-4-butoxybenzoic acid 2-[2-(diethylamino)ethoxy]ethyl ester
Additional Names: 2-diethylaminoethoxyethyl 3-amino-4-butoxybenzoate
Percent Composition: C 64.74%, H 9.15%, N 7....
Literature References: Prepn and properties: E. Cuingnet, US 3209022 (1965 to Corbiere). Ionization potential: A. Cier et al., Therapie 26, 941 (1971). Investigations of possible antifibrillatory properties: P. Amaud et al., C.R. Seances Soc. Biol. Ses Fil. 159, 2427 (1965); G. Faucon et al., Therapie 21, 1253 (1966).

Methoxyflurane CAS Registry Number: 76-38-0 甲氧氟烷

CAS Name: 2,2-Dichloro-1,1-difluoro-1-methoxyethane
Additional Names: 2,2-dichloro-1,1-difluoroethyl methyl ether; 1,1-difluoro-2,2-dichloroethyl methyl etherTrademarks: Metofane (Vericore); Pe...
Literature References: Prepn and properties: Miller et al., J. Am. Chem. Soc. 70, 431 (1948); Park et al., ibid. 73, 861 (1951); GB 754976 (1956 to Standard Tele. Cable).

Metaproterenol CAS Registry Number: 586-06-1 奥西那林

CAS Name: 5-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]-1,3-benzenediol
Additional Names: 3,5-dihydroxy-a-[(isopropylamino)methyl]benzyl alcohol; 1-(3,5-dihydroxyphenyl)-2-isopropylaminoethanol; ...
Literature References: Prepn and resolution of d- and l-forms: BE 611502; O. Thoma, K. Zeile, US 3341594 (1961, 1967 both to Boehringer, Ing.). Pharmacology: H. H. Pelz, Am. J. Med. Sci. 253, 321 (1967). Metabolism: K. Tatsumi et al., Yakugaku Zasshi 90, 639 (1970); ibid. 91, 680 (1971). Toxicity: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971). Review of clinical toxicology: J. D. Truwit, Crit. Care Clin. 7, 639-657 (1991).

N-Methylepinephrine CAS Registry Number: 554-99-4 4-(2-二甲基氨基-1-羟基乙基)苯-1,2-二醇

CAS Name: 4-[2-(Dimethylamino)-1-hydroxyethyl]-1,2-benzenediol
Additional Names: a-[(dimethylamino)methyl]-3,4-dihydroxybenzyl alcohol; a-(3,4-dihydroxyphenyl)-2-dimethylaminoethanol; a-(3,4-di...
Literature References: Prepn and resolution of racemic mixture: Manna, Campiglio, Farmaco Ed. Sci. 14, 317 (1959). Configuration: Manna, Ghislandi, ibid. 19, 377 (1964).

o-Dichlorobenzene CAS Registry Number: 95-50-1 邻二氯苯

CAS Name: 1,2-Dichlorobenzene
Additional Names: orthodichlorobenzene
Percent Composition: C 49.02%, H 2.74%, Cl 48.24%
Literature References: Prepn and separation from m- and p-dichlorobenzenes, see m-isomer above. Manuf: Faith, Keyes Clark's Industrial Chemicals, F. A. Lowenheim, M. K. Moran, Eds. (Wiley-Interscience, New York, 4th ed., 1975) pp 258-265. Review of toxicology: Rev. Environ. Contam. Toxicol. 106, 51-68 (1988).

Vintiamol CAS Registry Number: 26242-33-1 N-[(4-氨基-2-甲基-5-嘧啶基)甲基]-N-[4-羟基-1-甲基-2-[(3-氧代-3-苯基-1-丙烯-1-基)硫代]-1-丁烯-1-基]-甲酰胺

CAS Name: N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[(3-oxo-3-phenyl-1-propenyl)thio]-1-butenyl]formamide
Additional Names: N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N...
Literature References: Prepn and sepn of isomers: Fusco, Tenconi, Farmaco Ed. Sci. 20, 866 (1965).

Ammonium Nitroferricyanide CAS Registry Number: 14402-70-1

CAS Name: Diammonium pentakis(cyano-C)nitrosylferrate(2-)
Additional Names: ammonium pentacyanonitrosylferrate(III); ammonium nitroprusside
Percent Composition: C 23.83%, H 3.20%, Fe 22.16%,...
Literature References: Prepn and structure: Burrows, Turner, J. Chem. Soc. 115, 1429 (1919).