其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Dicyclohexylamine CAS Registry Number: 101-83-7 二环己胺

CAS Name: N-Cyclohexylcyclohexanamine
Additional Names: dodecahydrodiphenylamine
Percent Composition: C 79.49%, H 12.79%, N 7.72%
Literature References: Prepn by hydrogenation of equimolar amounts of cyclohexanone and cyclohexylamine: C. F. Winans, H. Adkins, J. Org. Chem. 54, 306 (1932); R. M. Robinson, W. C. Braaten, US 3154580 (1964 to Abbott). Forms crystalline derivatives with N-protected amino acids: E. Klieger et al., Ann. 640, 157 (1961). Review: T. S. Carswell, H. L. Morrill, Ind. Eng. Chem. 29, 1265 (1937).

Ergostanol CAS Registry Number: 6538-02-9 (3beta,5alpha)-麦角甾烷-3-醇

CAS Name: (3b,5a)-Ergostan-3-ol
Percent Composition: C 83.51%, H 12.51%, O 3.97%
Literature References: Prepn by hydrogenation of ergosta-14,22-dien-7-one: Chen, Ber. 70, 1432 (1937).

Dicyanine CAS Registry Number: 52260-69-2 1-乙基-2-[3-(1-乙基-2-甲基-4(1H)-喹啉亚基)丙-1-烯基]-4-甲基喹啉鎓碘化物

CAS Name: 1-Ethyl-2-[3-(1-ethyl-2-methyl-4(1H)-quinolinylidene)-1-propenyl]-4-methylquinolinium iodide
Additional Names: 1-ethyl-2-[3-(1-ethyl-4(1H)-quinaldylidene)propenyl]lepidinium iodide; 1...
Literature References: Prepn by J. A. Aeschlimann as reported by Mills, Odams, J. Chem. Soc. 125, 1913 (1924). See also Beilstein 2nd suppl. vol. 23, p 284. Has photoconductive properties that increase sharply with a rise in temp and is classed as an O2-photoconductor: Meier, Z. Phys. Chem. (Leipzig) 208, 325 (1958). Gives a color reaction with magnesium ions: Babenko, Zh. Anal. Khim. 13, 496 (1958).

m-Nitroaniline CAS Registry Number: 99-09-2 间硝基苯胺

CAS Name: 3-Nitrobenzenamine
Additional Names: m-nitraniline
Percent Composition: C 52.18%, H 4.38%, N 20.28%, O 23.17%
Literature References: Prepn by nitration of aniline: Holleman et al., Ber. 44, 704 (1911); by reduction of m-dinitrobenzene: Brady et al., J. Chem. Soc. 1929, 2266; Kubota et al., J. Pharm. Soc. Jpn. 76, 801 (1956); Kuhn, US 2768209 (1956 to Ringwood); from m-nitrobenzoic acid: Snyder et al., J. Am. Chem. Soc. 75, 2014 (1953).

Sulfasymazine CAS Registry Number: 1984-94-7 磺胺均三嗪

CAS Name: 4-Amino-N-(4,6-diethyl-1,3,5-triazin-2-yl)benzenesulfonamide
Additional Names: N1-(4,6-diethyl-s-triazin-2-yl)sulfanilamide; 2-sulfanilamido-4,6-diethyl-1,3,5-triazine; 4,6-diethyl-2-...
Literature References: Prepn by nucleophilic displacement of methoxy groups from 2-methoxy-4,6-disubstituted s-triazines with sulfanilamide anion: Taft et al., J. Med. Chem. 8, 784 (1965); Bader, US 3344137 (1967 to Am. Cyanamid). Pharmacological studies: Frisk, Hultman, Antimicrob. Agents Chemother. 1965, 672; Kruger-Thiemer et al., Chemotherapia 10, 325 (1966).

Gluconolactone CAS Registry Number: 90-80-2 葡萄糖酸内酯

CAS Name: D-Gluconic acid d-lactone
Additional Names: glucono delta lactone; delta gluconolactone
Trademarks: Fujiglucon (Fujisawa)
Percent Composition: C 40.45%, H 5.66%, O 53.89%
Literature References: Prepn by oxidation of glucose with bromine water: Isbell, Pigman, J. Res. Natl. Bur. Stand. 10, 337 (1933); by oxidation of glucose in Acetobacter suboxydans: King, Cheldelin, Biochem. J. 68, 31P (1958). Structure: J. Stanék et al., The Monosaccharides (Academic Press, New York, 1963) p 271.

Amixetrine CAS Registry Number: 24622-72-8 阿米西群

CAS Name: 1-[2-(3-Methylbutoxy)-2-phenylethyl]pyrrolidine
Additional Names: 1-[b-(isopentyloxy)phenethyl]pyrrolidine; N-(2-phenyl-2-isoamyloxy)ethylpyrrolidine
Percent Composition: C 78.11%,...
Literature References: Prepn by reacting styrene and isoamyl alcohol with t-butyl hypobromite and then condensing the product with pyrrolidine: Mauvernay, Busch, DE 1811767 (1969 to C.E.R.M.), C.A. 72, 21607e (1970). Identification of urinary metabolites in humans and dogs: M. Constantin et al., Arzneim.-Forsch. 26, 80 (1976). Pharmcokinetics: M. Constantin, J. F. Pognat, ibid. 28, 646 (1978).

Fospirate CAS Registry Number: 5598-52-7 福司吡酯

CAS Name: Dimethylphosphoric acid 3,5,6-trichloro-2-pyridinyl ester
Additional Names: O,O-dimethyl-O-3,5,6-trichloro-2-pyridyl phosphateTrademarks: Torelle (Dow)
Percent Composition: C 27.43...
Literature References: Prepn by reaction of 3,5,6-trihalo-2-pyridinol with phosphoryl chloride: Rigterink, Kenaga, J. Agric. Food Chem. 14, 304 (1966).

Duroquinone CAS Registry Number: 527-17-3 四甲基-1,4-苯醌

CAS Name: 2,3,5,6-Tetramethyl-2,5-cyclohexadiene-1,4-dione
Additional Names: tetramethyl-p-benzoquinone
Percent Composition: C 73.15%, H 7.37%, O 19.49%
Literature References: Prepn by reduction of dinitrodurene: Smith, Org. Synth. vol. 10, 40 (1930); Smith, Dobrovolny, J. Am. Chem. Soc. 48, 1420 (1926); by condensation of 2,3-diketopentane with itself in presence of alkalies: von Pechmann, Ber. 21, 1420 (1888); by the action of alkalies on 3,3-dichloropentan-2-one: Faworsky, J. Prakt. Chem. [2] 51, 538 (1895).

Mesalamine CAS Registry Number: 89-57-6 5-氨基水杨酸

CAS Name: 5-Amino-2-hydroxybenzoic acid
Additional Names: 5-aminosalicylic acid; 5-amino-2-hydroxybenzene-1-carboxylic acid; m-aminosalicylic acid; fisalamine; mesalazine; 5-ASA
Trademarks: ...
Literature References: Prepn by reduction of m-nitrobenzoic acid with Zn dust and HCl: H. Weil et al., Ber. 55B, 2664 (1922); by electrolytic reduction: Le Guyader, Peltier, Compt. Rend. 253, 2544 (1961). Use in manufacture of dyes: GB 751386 (1956 to J. R. Geigy). Identification as active metabolite of sulfasalazine, q.v.: A. K. Azad Khan et al., Lancet 2, 892 (1977); P. A. M. Van Hees et al., Gut 21, 632 (1980). HPLC determn in serum: E. Brendel et al., J. Chromatogr. 385, 299 (1987). Bioavailability, plasma level and excretion: S. N. Rasmussen et al., Gastroenterology 83, 1062 (1982). Clinical evaluation in Crohn's disease: eidem, ibid. 85, 1350 (1983). Clinical trials in ulcerative colitis: M. Campieri et al., Lancet 2, 270 (1981); L. S. Friedman et al., Am. J. Gastroenterol. 81, 412 (1986); in comparison with olsalazine, q.v.: S. S. Rao et al., Scand. J. Gastroenterol. 22, 332 (1987). Brief review: G. Friedman, Am. J. Gastroenterol. 81, 141-144 (1986). Review of clinical efficacy in colonic diverticulosis: A. Tursi, Expert Opin. Pharmacother. 6, 69-74 (2005).