其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

n-Butyl Propionate CAS Registry Number: 590-01-2 丙酸丁酯

CAS Name: Propanoic acid butyl ester
Additional Names: propionic acid butyl ester
Percent Composition: C 64.58%, H 10.84%, O 24.58%
Literature References: Prepn from 1-butanol and propionic acid: Vogel, J. Chem. Soc. 1948, 616; Spindt, Stevens, US 2470876 (1949 to Gulf).

Dithiazanine Iodide CAS Registry Number: 514-73-8 3,3'-二乙基硫二碳碘化氰

CAS Name: 3-Ethyl-2-[5-(3-ethyl-2(3H)-benzothiazolylidene)-1,3-pentadienyl]benzothiazolium iodide
Additional Names: 3,3'-diethylthiadicarbocyanine iodide
Trademarks: Abminthic (Pfizer); Anel...
Literature References: Prepn from 1-methylbenzothiazole ethiodide and b-(ethylmercapto)acrolein diethyl acetal: Kendall, Edwards, US 2412815 (1946 to Ilford).

Bithionol CAS Registry Number: 97-18-7 硫双二氯酚

CAS Name: 2,2'-Thiobis[4,6-dichlorophenol]
Additional Names: TBP; bis(2-hydroxy-3,5-dichlorophenyl)sulfideTrademarks: Bithin; Lorothidol
Percent Composition: C 40.48%, H 1.70%, Cl 39.83%, O ...
Literature References: Prepn from 2,4-halo substituted phenol with S halides: Muth, DE 583055 (1933 to I. G. Farbenind.), C.A. 28, 179 (1934); Copper, Godfrey, US 2849494 (1958 to Monsanto). Comprehensive review and bibliography: Shumard et al., Soap Sanit. Chem. 29, no. 1, 34-37, 90 (1953). Anthelmintic activity of the sulfoxide: J. Guilhon, M. Graber, Bull. Acad. Vet. Fr. 52, 225 (1979). Metabolism of the sulfoxide in humans: M. Sakamoto et al., J. Toxicol. Sci. 6, 307 (1981).

Mexazolam CAS Registry Number: 31868-18-5 美沙唑仑

CAS Name: 10-Chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro-3-methyloxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one
Additional Names: 10-chloro-11b-(o-chlorophenyl)-2,3,7,11b-tetrahydro-3-methylox...
Literature References: Prepn from 2-amino-2¢,5-dichlorobenzophenone: R. Tachikawa et al., DE 1812252; eidem, US 3772371 (1969, 1973 to Sankyo). Synthesis via Schiff base, physical properties: T. Miyadera et al., J. Med. Chem. 14, 520 (1971). Acid-base equilibrium: M. Ikeda, T. Nagai, Chem. Pharm. Bull. 30, 3810 (1982). Effect on socially induced suppression in monkeys: T. Kamioka et al., Psychopharmacology 52, 17 (1977). Toxicity studies: H. Masuda et al., Sankyo Kenkyusho Nempo 30, 175 (1978), C.A. 90, 180217d. Clinical effects on anxiety and pyschomotor performance in generalised anxiety disorder: L. Ferreira et al., Clin. Drug Invest. 23, 235 (2003).

Chlorzoxazone CAS Registry Number: 95-25-0 氯唑沙宗

CAS Name: 5-Chloro-2(3H)-benzoxazolone
Additional Names: 5-chloro-2-benzoxazolol; 5-chloro-2-hydroxybenzoxazole; 2-hydroxy-5-chlorobenzoxazole; 5-chlorbenzoxazolin-2-one; 5-chlorobenzoxazolidon...
Literature References: Prepn from 2-amino-5-chlorobenzoxazole: Marsh, US 2895877 (1959 to McNeil Labs.). LC determn in plasma: I. L. Honigsberg et al., J. Pharm. Sci. 68, 253 (1979). Fluorometric determn in tablets and biological fluids: J. T. Stewart, C. W. Chan, ibid. 910. Clinical studies: R. Herman, Curr. Ther. Res. 9, 537 (1967); J. J. Scheiner, ibid. 19, 51 (1976). Metabolism study: R. Twele, G. Spiteller, Arzneim.-Forsch. 32, 759 (1982). Toxicity: G. Hofrichter et al., Arzneim.-Forsch. 17, 242 (1967). Review of clinical studies: J. K. Elenbaas, Am. J. Hosp. Pharm. 37, 1313 (1980). Comprehensive description: J. T. Stewart, C. A. Janicki, Anal. Profiles Drug Subs. 16, 119-144 (1987).

Metamfepramone CAS Registry Number: 15351-09-4 甲胺苯丙酮

CAS Name: 2-(Dimethylamino)-1-phenylpropanone
Additional Names: 2-(dimethylamino)propiophenone; benzoyl-a-(dimethylamino)ethane; a-(dimethylamino)propiophenone; metamfepyramone; N-methylephedro...
Literature References: Prepn from 2-bromopropiophenone and dimethylamine: Thomson, Stevens, J. Chem. Soc. 1932, 1932; from N,N-dimethyl-2-(dimethylamino)propionamide and phenylmagnesium bromide: Eidebenz, Arch. Pharm. 280, 49 (1942); from a-acetylbenzyl alcohol and dimethylamine: Iwao et al., J. Pharm. Soc. Jpn. 74, 551 (1954). Prepn of d-form: Freudenberg, Nikolai, Ann. 510, 223 (1934). Resolution of dl-form: Takamatsu, J. Pharm. Soc. Jpn. 76, 1219 (1956).

Aklomide CAS Registry Number: 3011-89-0 2-氯-4-氰基苯甲酰胺

CAS Name: 2-Chloro-4-nitrobenzamide
Trademarks: Aklomix (Salsbury)
Percent Composition: C 41.92%, H 2.51%, Cl 17.68%, N 13.97%, O 23.93%
Literature References: Prepn from 2-chloro-4-nitrobenzoylchloride and ammonium carbonate: Grohmann, Ber. 24, 3813 (1891); Cosulich et al., J. Am. Chem. Soc. 75, 4675 (1953). Used vs infections caused by protozoa and bacteria: BE 608763 (1962 to Salsbury's Labs).

Lepidine CAS Registry Number: 491-35-0 4-甲基喹啉

CAS Name: 4-Methylquinoline
Additional Names: cincholepidine
Percent Composition: C 83.88%, H 6.34%, N 9.78%
Literature References: Prepn from 2-chlorolepidine: Neumann et al., Org. Synth. 26, 45 (1946); from aniline hydrochloride: Campbell, US 2451611 (1948 to du Pont); Bach, Rast, J. Prakt. Chem. 17, 63 (1962); from ethylacetanilide: Ardashev, Minkin, Zh. Obshch. Khim. 28, 1578 (1958).

Phenyramidol CAS Registry Number: 553-69-5 非尼拉朵

CAS Name: a-[(2-Pyridinylamino)methyl]benzenemethanol
Additional Names: 2-(b-hydroxyphenethylamino)pyridine; fenyramidol
Percent Composition: C 72.87%, H 6.59%, N 13.07%, O 7.47%
Literature References: Prepn from 2-mandelamidopyridine or 2-aminopyridine: Gray et al., J. Am. Chem. Soc. 81, 4347, 4351 (1959).

Methocarbamol CAS Registry Number: 532-03-6 美索巴莫

CAS Name: 3-(2-Methoxyphenoxy)-1,2-propanediol 1-carbamate
Additional Names: 3-(o-methoxyphenoxy)-2-hydroxypropyl 1-carbamate; 2-hydroxy-3-(o-methoxyphenoxy)propyl 1-carbamate; guaiacol glycery...
Literature References: Prepn from 3-(o-methoxyphenoxy)-2-hydroxypropyl chlorocarbonate: Murphey, US 2770649 (1956 to A. H. Robins). Comprehensive description: S. Alessi-Severini et al., Anal. Profiles Drug Subs. Excip. 23, 371-399 (1994).