Properties: Needles from ethanol + dichloromethane, mp 225°. [a]D22 +95° (c = 0.81 in CHCl3). uv max: 240 nm (e 16600).
Melting point: mp 225°
Optical Rotation: [a]D22 +95° (c = 0.81 in CHCl3)
Absorption maximum: uv max: 240 nm (e 16600)
Derivative Type: Cyclic acetal with acetone
CAS Registry Number: 4968-09-6
Additional Names: 16a,17-[(1-Methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione; algestone acetonide; alphasone acetonide; 16a,17a-isopropylidenedioxyprogesterone
Percent Composition: C 74.58%, H 8.87%, O 16.56%
Literature References: Prepn: Cooley et al., loc. cit; Fried et al., Chem. Ind. (London)
1961, 465.
Properties: Needles from aq ethanol, mp 210°. [a]D20 +137° (c = 0.7 in CHCl3).
Melting point: mp 210°
Optical Rotation: [a]D20 +137° (c = 0.7 in CHCl3)
Derivative Type: 16a-Methyl ether
Additional Names: 17-Hydroxy-16a-methoxypregn-4-ene-3,20-dione
Percent Composition: C 73.30%, H 8.95%, O 17.75%
Literature References: Prepd from the free diol via 16a,17-dihydroxypregn-4-ene-3,20-dione cyclic borate: Fried,
US
3006930 (1961 to Olin Mathieson).
Properties: Crystals from 95% ethanol, mp 142-143°. [a]D23 +60° (c = 0.15 in CHCl3). uv max: 234 nm (e 15400).
Melting point: mp 142-143°
Optical Rotation: [a]D23 +60° (c = 0.15 in CHCl3)
Absorption maximum: uv max: 234 nm (e 15400)
Therap-Cat: Acetonide as anti-inflammatory (topical).
Keywords: Glucocorticoid.
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