CAS: 595-77-7; Algestone

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CAS号1096-38-4 16-去氢黄体酮 | CAS号1096-38-4 16-去氢黄体酮

3-Ethylendioxy-20-Oxo-Pregna-5,16-Dien置于potassium Permanganate,Sodium Hydrogen Sulfate,盐酸体系中,用 水 作为反应溶剂,化学反应 11.0H,反应生成 双羟孕酮
参考文献:苯甲孕酮的制备方法
标题:苯甲孕酮的制备方法
摘要:本发明公开了一种苯甲孕酮的制备方法.它包括以下步骤:1)将雄烯二酮氰醇缩酮物与1~1.5倍物质的量的三氯氧磷,1~10倍物质的量的碱性介质进行反应,反应温度为‑10~80°C,反应时间为1~5小时,得到消除物;2)将上述消除物与1~10倍物质的量的氯镁甲基反应,反应温度为‑10~70°C,反应时间为1~5小时;得到产物格氏物.3)将上述格氏物与1~5倍物质的量的高锰酸钾反应,反应温度为‑10~30°C,反应时间为10~60分钟,然后与1~5倍物质的量的酸反应,反应温度为‑10~30°C,反应时间为1~10小时,得到羟基物;5)将羟基物与0.025~0.1倍物质的量的催化剂,2~10倍物质的量的苯乙酮反应,反应温度为‑10~30°C,反应时间为1~10小时,得到苯甲孕酮.不但提高了产品的质量和收率同时还节约了生产成本,缩短了工艺时间.

专利信息

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-2025206736-A1
优先权日:2019-11-14
标题 :Synthesis of kras g12c inhibitor compound
发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
权利人:AMGEN INC
摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.

专利号:US-2024287041-A1
优先权日:2021-05-20
标题 :Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms
发明人：BALOGLU ERKAN; AUSTAD BRIAN C; ROE DAVID G; KEDUC ANDREW; GOTTSCHLING STEPHEN EDMUND; HECKER EVAN
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The present invention relates to a method of preparing a compound represented by structural formula (VII), comprising reacting a compound represented by structural formula (II), with a compound represented by structural formula (III), in a solvent, in the presence of a Pd catalyst and one or more inorganic bases under conditions suitable to prepare a compound represented by structural formula (VII): The values and example values of the variables in structural formulas (VII), (II), and (III) are defined herein. The present invention also relates to crystalline Forms I and II of the compound represented by Structural Formula (VII), the use of the crystalline Forms in treating disease or disorders associated with CRM1 and method of preparing the crystalline Forms.

专利号:AU-2022276509-A1
优先权日:2021-05-20
标题:Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms

专利号:US-9994558-B2
优先权日:2013-09-20
标题 :Multicyclic compounds and methods of using same
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).

专利号:US-2023192682-A1
优先权日:2019-11-14
标题:Improved synthesis of kras g12c inhibitor compound