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Tetrahydrofuran CAS Registry Number: 109-99-9 四氢呋喃


Additional Names: Diethylene oxide; tetramethylene oxide
Percent Composition: C 66.62%, H 11.18%, O 22.19%
📌 参考资料/链接:
Literature References: Prepn from 1,4-butanediol: Schmoyer, Case, Nature 187, 592 (1960). Manuf by catalytic hydrogenation of maleic anhydride: Gilbert, Howk, US 2772293 (1956 to du Pont); of furan: Banford, Manes, US 2846449 (1958 to du Pont); Manly, US 3021342 (1962 to Quaker Oats). Stabilization to prevent excessive peroxide formation on storage with 0.05-1.0% p-cresol, 0.05-0.1% hydroquinone, or less than 0.01-0.1% 4,4¢-thiobis(6-tert-butyl-m-cresol): Bordner, Hinegardner, US 2489260; US 2525410; Campbell, US 3029257 (1949, 1950, 1962 all to du Pont). Review of toxicology and biological effects: D. E. Moody, Drug Chem. Toxicol. 14, 319-342 (1991).

📄 详细内容


Properties: Liquid. Ether-like odor. mp -108.5°. d420 0.8892. bp760 66°; bp176 25°. Flash pt 1°F. nD20 1.4070. Dipole moment: 1.70. uv cut-off for spectro grade: 220 nm. Miscible with water, alcohols, ketones, esters, ethers, and hydrocarbons. Caution: Distil only in presence of a reducing agent, such as ferrous sulfate; peroxide explosions have occurred: Angew. Chem.
68, 182 (1956).
Melting point: mp -108.5°
Boiling point: bp760 66°; bp176 25°
Flash point: Flash pt 1°F
Index of refraction: nD20 1.4070
Density: d420 0.8892
CAUTION: Potential symptoms of overexposure are irritation of eyes and upper respiratory system; nausea, dizziness and headache; CNS depression. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 302.
Use: Solvent for high polymers, esp polyvinyl chloride. As reaction medium for Grignard and metal hydride reactions. In the synthesis of butyrolactone, succinic acid, 1,4-butanediol diacetate. Solvent in histological techniques. May be used under Federal Food, Drug Cosmetic Act for fabrication of articles for packaging, transporting, or storing of foods if residual amount does not exceed 1.5% of the film: Fed. Regist.
27, 3919 (Apr. 25, 1962).
产品链接: 109-99-9››