其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

p-Chlorophenacyl Bromide CAS Registry Number: 536-38-9 α-溴代-4-氯苯乙酮

CAS Name: 2-Bromo-1-(4-chlorophenyl)ethanone
Additional Names: 2-bromo-4'-chloroacetophenone; 4-chloro-w-bromoacetophenone; a-bromo-p-chloroacetophenone
Percent Composition: C 41.15%, H 2.59...
Literature References: Prepn from bromoacetyl chloride, chlorobenzene, and AlCl3: Collet, Compt. Rend. 125, 718 (1897); by bromination of p-chloroacetophenone: idem, Bull. Soc. Chim. Fr. [3] 21, 69 (1899). Toxicity study: Dat-Xuong et al., Med. Exp. 11(3), 137 (1964).

Dibutyl Succinate CAS Registry Number: 141-03-7 丁二酸二丁酯

CAS Name: Butanedioic acid dibutyl ester
Additional Names: succinic acid dibutyl ester; di-n-butyl succinate
Trademarks: Tabutrex; Tabatrex (Glenn)
Percent Composition: C 62.58%, H 9.63%,...
Literature References: Prepn from butyl alcohol and succinic acid: Vogel, J. Chem. Soc. 1948, 624.

n-Butyl n-Butyrate CAS Registry Number: 109-21-7 丁酸丁酯

CAS Name: Butanoic acid butyl ester
Additional Names: butyric acid butyl ester
Percent Composition: C 66.63%, H 11.18%, O 22.19%
Literature References: Prepn from butyl alcohol: Robertson, Org. Synth. coll. vol. I, 138 (1941); Horton, US 2522676 (1950 to Socony-Vacuum Oil).

n-Dibutylamine CAS Registry Number: 111-92-2 二正丁胺

CAS Name: N-Butyl-1-butanamine
Percent Composition: C 74.35%, H 14.82%, N 10.84%
Literature References: Prepn from butyl bromide and ammonia with separation of the mono-, di-, and tributylamines formed: Werner, J. Chem. Soc. 115, 1010 (1919). Manuf: Engel, Hoog, US 2574693 (1951 to Shell); Davies et al., US 2609394 (1952 to I.C.I.); Lemon, Myerly, US 3022349 (1962 to Union Carbide); Brois, Rutkowski, US 3147310 (1964 to Esso). Toxicity study: H. F. Smyth et al., Arch. Ind. Hyg. Occup. Med. 10, 61 (1954).

Butylidene Chloride CAS Registry Number: 541-33-3 1,1-二氯丁烷

CAS Name: 1,1-Dichlorobutane
Percent Composition: C 37.83%, H 6.35%, Cl 55.83%
Literature References: Prepn from butyraldehyde and PCl5: Henne et al., J. Am. Chem. Soc. 61, 938 (1939).

Cacodyl CAS Registry Number: 471-35-2

CAS Name: Tetramethyldiarsine
Additional Names: dicacodyl
Percent Composition: C 22.88%, H 5.76%, As 71.36%
Literature References: Prepn from cacodyl chloride by heating with zinc in an atm of carbon dioxide: Bunsen, Ann. 42, 14 (1842); from dimethylarsine by the action of oxides of nitrogen, aqueous chromic acid, lead peroxide, cacodyl chloride or potassium ferricyanide: Dehn, Wilcox, Am. Chem. J. 35, 1 (1906); by the action of free methyl on arsenic: Paneth, Loleit, J. Chem. Soc. 1935, 366; by reduction of cacodyl oxide: Witten, US 2531487 (1950 to U.S.A.); Fuson, Shive, US 2756245 (1956 to U.S.A.).

Hydroorotic Acid CAS Registry Number: 155-54-4 2,6-二氧代六氢嘧啶-4-羧酸

CAS Name: Hexahydro-2,6-dioxo-4-pyrimidinecarboxylic acid
Additional Names: 4,5-dihydroorotic acid
Percent Composition: C 37.98%, H 3.82%, N 17.72%, O 40.48%
Literature References: Prepn from carbethoxyasparagine: Miller et al., J. Am. Chem. Soc. 75, 6086 (1953); US 2773872 (1956 to Merck Co.).

Undecylenic Acid CAS Registry Number: 112-38-9 十一烯酸

CAS Name: 10-Undecenoic acid
Additional Names: 10-hendecenoic acid; 9-undecylenic acid
Trademarks: Fungoid Solution (Pedinol); Mycodécyl Solution (Doms-Adrian)
Percent Composition: C 71.6...
Literature References: Prepn from castor oil: Krafft, Ber. 10, 2035 (1877); Perkins, Cruz, J. Am. Chem. Soc. 49, 1073 (1927); G. Das et al., J. Am. Oil Chem. Soc. 66, 938 (1989). Toxicology: G. W. Newell et al., J. Invest. Dermatol. 13, 145 (1949). Clinical trials: A. L. Shapiro, S. Rothman, Arch. Dermatol. Syphilol. 52, 166 (1945), republ. in Arch. Dermatol. 119, 345 (1983); J. H. Chretien et al., Int. J. Dermatol. 19, 51 (1980). Historical review: J. W. Landau, Arch. Dermatol. 119, 351-353 (1983).

Protocatechualdehyde CAS Registry Number: 139-85-5 原儿茶醛; 原二茶醛; 茶酚甲醛; 茶醛; 3,4-二羟基苯甲醛

CAS Name: 3,4-Dihydroxybenzaldehyde
Additional Names: 3,4-dihydroxybenzenecarbonal; protocatechuic aldehyde; rancinamycin IV
Percent Composition: C 60.87%, H 4.38%, O 34.75%
Literature References: Prepn from catechol: Reimer, Tiemann, Ber. 9, 1268 (1876); Tiemann, Koppe, ibid. 14, 2015 (1881); from vanillin: Tiemann, Haarmann, ibid. 7, 620 (1874); from veratric aldehyde: Dreyfus, DE 193958; Frdl. 9, 161 (1908-10); from piperonal: Hoering, Baum, Ber. 41, 1914 (1908); Barger, J. Chem. Soc. 93, 563 (1908); Buck, Zimmerman, Org. Synth. coll. vol. II, 549 (1943).

Cerous Iodide CAS Registry Number: 7790-87-6 三碘化铈

Percent Composition: Ce 26.90%, I 73.10%
Literature References: Prepn from Ce and HgI2: Asprey et al., Inorg. Chem. 3, 1137 (1964); from the oxide and HI in the presence of NH4I: Taylor, Curtis, J. Inorg. Nucl. Chem. 24, 387 (1962).