其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Ecgonidine CAS Registry Number: 484-93-5

CAS Name: (1R)-8-Methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylic acid
Additional Names: 2-tropidinecarboxylic acid; anhydroecgonin
Percent Composition: C 64.65%, H 7.84%, N 8.38%, O 19.14%
Literature References: Prepn from ecgonine and structure: Findlay, J. Am. Chem. Soc. 75, 1033 (1953). Prepn and formation of l-form: de Jong, Rec. Trav. Chim. 42, 980 (1923), 66, 99 (1947). Synthesis of dl-form: Grundmann, Ottmann, Ann. 605, 24 (1957); US 2783235 (1957 to Olin Mathieson).

Imidazole Salicylate CAS Registry Number: 36364-49-5 水杨酸咪唑

CAS Name: 2-Hydroxybenzoic acid compd with 1H-imidazole (1:1)
Additional Names: mono(2-hydroxybenzoate)-1H-imidazole; salizoloTrademarks: Flogozen (SPA); Selezen (Italfarmaco)
Percent Compos...
Literature References: Prepn from equimolar amounts of salicylic acid with imidazole: M. Brissemoret, Bull. Soc. Chim. Fr. [3] 35, 316 (1906). Use as anti-inflammatory agent: BE 889704; G. Sportoletti, US 4329340 (1981, 1982 both to Italfarmaco). Pharmacology: P. G. Pagella et al., Arzneim.-Forsch. 33, 716 (1983). Penetration of inflamed sites: eidem, ibid. 34, 208 (1984). Pharmacokinetics: H. P. Kuemmerle et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 22, 521 (1984). Series of clinical studies: Boll. Chim. Farm. 122, 37S-63S (1983). Review: R. Fantozzi, Drugs Exp. Clin. Res. 10, 853-856 (1984).

Erythritol Anhydride CAS Registry Number: 564-00-1 内消旋-1,2:3,4-二环氧丁烷

CAS Name: (2R,2'S)-rel-2,2'-Bioxirane
Additional Names: meso-1,2:3,4-diepoxybutane; butadiene diepoxide; butadiene dioxide; butanedione
Trademarks: Bioxiran
Percent Composition: C 55.81%,...
Literature References: Prepn from erythrityl chlorohydrin: Przybytek, Ber. 17, 1091 (1884); by refluxing 1,4-dichloro-2,3-butanediol in tetrahydrofuran with NaOH: Reppe, Ann. 596, 141 (1955); meso-form from 1,4-dihydroxy-2-butene or from 3,4-epoxy-1-butene and dl-form from 1,4-dibromo-2-butene: Beech, J. Chem. Soc. 1951, 2483. Use to prevent microbial spoilage: H. D. Michener, J. C. Lewis, US 2934439 (1960 to U.S. Secy of Agr.). Toxicity data: H. F. Smyth et al., Arch. Ind. Hyg. Occup. Med. 10, 61 (1954).

n-Butyl Carbonate CAS Registry Number: 542-52-9 碳酸二正丁酯

CAS Name: Carbonic acid dibutyl ester
Additional Names: dibutyl carbonate
Percent Composition: C 62.04%, H 10.41%, O 27.55%
Literature References: Prepn from ethyl carbonate, butyl alcohol and ethylmagnesium bromide: Frank et al., J. Am. Chem. Soc. 66, 1509 (1944); from butyl alcohol and CO in the presence of Pd and CuCl2: Mador, Blackham, US 3114762 (1963 to National Distillers).

Chloroacetamide CAS Registry Number: 79-07-2 氯乙酰胺

CAS Name: 2-Chloroacetamide
Percent Composition: C 25.69%, H 4.31%, Cl 37.91%, N 14.98%, O 17.11%
Literature References: Prepn from ethyl chloroacetate and ammonia: Jacobs, Heidelberger, Org. Synth. coll. vol. I, 153 (2nd ed., 1941); from chloroacetyl chloride and ammonium acetate: Finan, Fothergill, J. Chem. Soc. 1962, 2824.

Norcholanic Acid CAS Registry Number: 511-18-2 24-去甲-5beta-胆烷-23-酸

CAS Name: (5b)-24-Norcholan-23-oic acid
Percent Composition: C 79.71%, H 11.05%, O 9.23%
Literature References: Prepn from ethyl cholanate: Wieland et al., Z. Physiol. Chem. 161, 80 (1926); from 3,7-diketonorcholanic acid: Windaus, van Schoor, ibid. 173, 312 (1928); from 12-ketonorcholanic acid: Cook, Haslewood, J. Chem. Soc. 1934, 428; from 3a,23-dihydroxycholanic acid: Yanuka et al., Tetrahedron Lett. 1968, 1725.

N,N ¢ -Diethylcarbanilide CAS Registry Number: 85-98-3 1,3-二乙基-1,3-二苯基脲

CAS Name: N,N'-Diethyl-N,N'-diphenylurea
Additional Names: sym-diethyldiphenylurea; centralite I; ethyl centralite
Percent Composition: C 76.09%, H 7.51%, N 10.44%, O 5.96%
Literature References: Prepn from ethylaniline and phosgene: Michler, Ber. 9, 712 (1876). Alternate synthesis: N. R. Ayyangar et al., Chem. Ind. (London) 1988, 599.

Vinylidene Chloride CAS Registry Number: 75-35-4 1,1-二氯乙烯

CAS Name: 1,1-Dichloroethene
Additional Names: 1,1-dichloroethylene; asym-dichloroethylene
Percent Composition: C 24.78%, H 2.08%, Cl 73.14%
Literature References: Prepn from ethylene chloride: Reilly, US 2140548 (1938 to Dow); by dehydrochlorination of 1,1,2-trichloroethane: Conrad, Gould, US 2989570 (1961 to Ethyl Corp.). Review of production, properties and uses: D. S. Gibbs et al. in Kirk-Othmer Encyclopedia of Chemical Technology vol. 23 (Wiley-Interscience, New York, 3rd ed., 1982) pp 764-798; of toxicology and human exposure: Toxicological Profile for 1,1-Dichloroethene (PB 95-100152, 1994) 200 pp.

Methyl Cellosolve® (Carbide and Carbon Chem.) CAS Registry Number: 109-86-4 乙二醇甲醚

CAS Name: 2-Methoxyethanol
Additional Names: ethylene glycol monomethyl ether
Percent Composition: C 47.35%, H 10.60%, O 42.05%
Literature References: Prepn from ethylene oxide + methanol: Finch, Hagemeyer, US 2748171 (1956 to Kodak); from ethylene glycol + diazomethane: Hesse, Majumdar, Ber. 93, 1129 (1960). Toxicity data: Smyth, J. Ind. Hyg. Toxicol. 23, 259 (1941); Werner, ibid. 25, 157 (1943). Series of articles on toxicology: Environ. Health Perspect. 57, 1-275 (1984).

Carbitol® (Union Carbide) CAS Registry Number: 111-90-0 二乙二醇乙醚

CAS Name: 2-(2-Ethoxyethoxy)ethanol
Additional Names: diethylene glycol monoethyl ether; ethyl digol
Percent Composition: C 53.71%, H 10.52%, O 35.77%
Literature References: Prepn from ethylene oxide and 2-ethoxyethanol in the presence of SO2: Britton, Sexton, US 2807651 (1957 to Dow). Toxicity data: Smyth, Carpenter, J. Ind. Hyg. Toxicol. 30, 63 (1948).