其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Bis(p-dimethylaminobenzylidene)benzidine CAS Registry Number: 6001-51-0

CAS Name: N,N'-Bis[[4-(dimethylamino)phenyl]methylene][1,1'-biphenyl]-4,4'-diamine
Additional Names: 4,4'-di(4-dimethylaminobenzylideneamino)biphenyl; bis(4-dimethylaminobenzylidene)-p,p'-diami...
Literature References: Prepn from hydrazobenzene and p-dimethylaminobenzaldehyde: Sachs, Whittaker, Ber. 35, 1435 (1902).

Barbituric Acid CAS Registry Number: 67-52-7 巴比妥酸

CAS Name: 2,4,6(1H,3H,5H)-pyrimidinetrione
Additional Names: malonylurea; 2,4,6-trioxohexahydropyrimidine
Percent Composition: C 37.51%, H 3.15%, N 21.87%, O 37.47%
Literature References: Prepn from hydurilic acid + nitric acid: Baeyer, Ann. 127, 199 (1863); ibid. 130, 129 (1864). Structure: Mulder, Ber. 6, 1233 (1873). Prepd from ethyl malonate and urea using sodium ethoxide as a condensing agent: Dickey, Gray, Org. Synth. coll. vol. II, 60 (1943). Crystal structure: Bolton, Nature 201, 987 (1964). Toxicity study: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971). Unsubstituted barbituric acid has no hypnotic properties. Review: Carter, J. Chem. Educ. 28, 524 (1951).

Senecialdehyde CAS Registry Number: 107-86-8 异戊烯醛

CAS Name: 3-Methyl-2-butenal
Additional Names: 3,3-dimethylacrolein; 3-methylcrotonaldehyde; senecioaldehyde; b,b-dimethylacrolein
Percent Composition: C 71.39%, H 9.59%, O 19.02%
Literature References: Prepn from isoamyl alcohol: Fischer et al., Ber. 64, 30 (1931); Fischer, Löwenberg, Ann. 494, 272 (1932); cf. Burkhardt et al., GB 512465 (1939); Montavon, Saucy, US 2902515 (1959 to Hoffmann-La Roche).

Phorone CAS Registry Number: 504-20-1 2,6-二甲基-2,5-庚二烯-4-酮

CAS Name: 2,6-Dimethyl-2,5-heptadien-4-one
Additional Names: diisopropylideneacetone
Percent Composition: C 78.21%, H 10.21%, O 11.58%
Literature References: Prepn from isobutenyllithium + CO2: Braude, Timmons, J. Chem. Soc. 1950, 2000; from acetone: Dolgov, Samsonova, Zh. Obshch. Khim. 22, 632 (1952); Joseph, Blumenthal, J. Org. Chem. 24, 1371 (1959); Tsmur, Zh. Prikl. Khim. 34, 1628 (1961); M. Konieczny, G. Sosnovsky, Z. Naturforsch. 33B, 454 (1978).

Isobutyl Acetate CAS Registry Number: 110-19-0 乙酸异丁酯

Percent Composition: C 62.04%, H 10.41%, O 27.55%
Literature References: Prepn from isobutyl alcohol + acetic acid: BE 505023 (1951 to Soc. Belge de l'Azote et des Prod. Chim. du Marly); from methyl isobutyl ketone: White, Emmons, Tetrahedron 17, 31 (1962). Isoln from wood-rotting fungus, Endoconidiophora coerulescens Münch.: Birkinshaw, Morgan, Biochem. J. 47, 55 (1950).

Hypophosphoric Acid CAS Registry Number: 7803-60-3 连二磷酸

Percent Composition: H 2.49%, O 59.26%, P 38.24%
Literature References: Prepn from its salts: Salzer, Ann. 187, 322 (1877); 211, 1 (1882). Review: Ohashi, "Lower Oxo Acids of Phosphorus and Their Salts" in Topics in Phosphorus Chemistry Vol. 1, M. Grayson, E. J. Griffith, Eds. (Interscience, New York, 1964) pp 113-187.

Isopropenyl Acetate CAS Registry Number: 108-22-5 醋酸异丙烯酯

CAS Name: 1-Propen-2-ol acetate
Additional Names: 1-propen-2-yl acetate
Percent Composition: C 59.98%, H 8.05%, O 31.96%
Literature References: Prepn from ketene + acetone: Hull, Agett; Hagemeyer, US 2481669; US 2476860 (both 1949 to Eastman Kodak); Young, US 2461016; US 2511423 (1949, 1950 both to Carbide Carbon Chem.); Mawer, US 2684980 (1954 to I.C.I.); Buttner, Enk, US 2867653 (1959 to Wacker-Chemie). Use as reagent for acylation of potential enols: Hagemeyer, Hull, Ind. Eng. Chem. 41, 2920 (1949); Hull, Agett, US 2482066 (1949 to Eastman Kodak); Jeffery, Satchell, J. Chem. Soc. 1962, 1876, 1906. Toxicity study: Smyth et al., J. Ind. Hyg. Toxicol. 31, 60 (1949).

b -Eucaine CAS Registry Number: 500-34-5 2,2,6-三甲基-4-哌啶基苯甲酸酯

CAS Name: 2,2,6-Trimethyl-4-piperidinol benzoate (ester)
Additional Names: a-4-benzoyloxy-2,2,6-trimethylpiperidine; a-vinyldiacetonalkamine benzoate; benzamine; betacaine; eucaine B
Percent...
Literature References: Prepn from lower melting form (a-form) of 2,2,6-trimethyl-4-piperidinol and benzoyl chloride: Harries, Ann. 417, 107, see p 175 (1918). Stereochemistry: King, J. Chem. Soc. 125, 41 (1924); Stenlake, J. Pharm. Pharmacol. 6, 164 (1954). Configuration: Perks, Russell, ibid. 19, 318 (1966). Toxicity data: Hirschfelder, Physiol. Rev. 12, 262 (1932).

N-Phenylmaleimide CAS Registry Number: 941-69-5 N-苯基马来酰亚胺

CAS Name: 1-Phenyl-1H-pyrrole-2,5-dione
Percent Composition: C 69.36%, H 4.07%, N 8.09%, O 18.48%
Literature References: Prepn from maleanilic acid: Cava et al., Org. Synth. 41, 93 (1961).

Diethyl Maleate CAS Registry Number: 141-05-9 顺丁烯二甲酸二乙酯

CAS Name: (2Z)-2-Butenedioic acid, diethyl ester
Additional Names: maleic acid, diethyl ester; ethyl maleate
Percent Composition: C 55.81%, H 7.02%, O 37.17%
Literature References: Prepn from maleic acid and ethanol: V. M. Mitchovitch, Bull. Soc. Chim. Fr. 4, 1667 (1937). Physical properties: G. H. Jeffrey, A. I. Vogel, J. Chem. Soc. 1948, 658. Copolymerization with styrene: F. M. Lewis et al., J. Am. Chem. Soc. 70, 1519, 1529 (1948). In Diels-Alder reactions: N. L. Bauld et al., Tetrahedron Lett. 1972, 2443. In Michael additions: G. Arsenault et al., Chem. Commun. 1983, 437. Conjugation with glutathione, q.v.: E. Boyland, L. F. Chasseaud, Biochem. J. 104, 95 (1967); eidem, ibid. 109, 651 (1968). Toxicity: H. F. Smyth et al., J. Ind. Hyg. Toxicol. 31, 60 (1949).