其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Carbostyril CAS Registry Number: 59-31-4 2-羟基喹啉

CAS Name: 2(1H)-Quinolinone
Additional Names: 2-hydroxyquinoline; 2-quinolinol; 2(1H)-quinolone; o-aminocinnamic acid lactam
Percent Composition: C 74.47%, H 4.86%, N 9.65%, O 11.02%
Literature References: Prepn from quinoline by heating with potassium hydroxide to 225° under anhydr conditions: Tschitschibabin, Ber. 56, 1883 (1923); DE 406208; Chem. Zentralbl. 1925, I, 1536; Frdl. 14, 515.

Methyl Linoleate CAS Registry Number: 112-63-0 亚油酸甲酯

CAS Name: 9,12-Octadecadienoic acid methyl ester
Percent Composition: C 77.50%, H 11.64%, O 10.87%
Literature References: Prepn from safflower-seed oil: Parker et al., Biochem. Prep. 4, 88 (1955).

Dithiosalicylic Acid CAS Registry Number: 527-89-9 二硫代水杨酸

CAS Name: 2-Hydroxybenzenecarbodithioic acid
Percent Composition: C 49.38%, H 3.55%, O 9.40%, S 37.67%
Literature References: Prepn from salicylaldehyde and ammonium polysulfide: Bruni, Levi, Atti Accad. Naz. Lincei 32, (i), 5 (1923), C.A. 18, 2694 (1924); Beilstein 2nd suppl. vol. 10, 78.

Methyl Carbamate CAS Registry Number: 598-55-0 氨基甲酸甲酯

Additional Names: Urethylane; methylurethane
Percent Composition: C 32.00%, H 6.71%, N 18.66%, O 42.63%
Literature References: Prepn from silver or mercuricyanate with H2S and methanol: Birkenbach, Kolb, Ber. 68, 901 (1935). From urea and methanol: DE 753127 (1940 to I.G. Farbenind.).

Butyl Stearate CAS Registry Number: 123-95-5 硬脂酸丁酯

CAS Name: Octadecanoic acid butyl ester
Percent Composition: C 77.58%, H 13.02%, O 9.40%
Literature References: Prepn from silver stearate and n-butyl iodide: Whitby, J. Chem. Soc. 1926, 1458; from stearic acid and n-butanol: Smith, ibid. 1931, 802. Physical properties: Beilstein vol. 2, Suppl. 3, 1016; Smith, loc. cit.; Ind. Eng. Chem. 32, 880 (1940).

a -Acetylbutyrolactone CAS Registry Number: 517-23-7 2-乙酰基-γ-丁内酯

CAS Name: 3-Acetyldihydro-2(3H)-furanone
Additional Names: a-(2-hydroxyethyl)acetoacetic acid g-lactone; a-acetyl-g-hydroxybutyric acid g-lactone; a-acetobutyrolactone
Percent Composition: C...
Literature References: Prepn from sodium acetoacetate and ethylene oxide in abs alcohol: Knunyantz et al., Compt. Rend. Acad. Sci. (U.R.S.S.) [N.S.] 1, 312 (1934), C.A. 28, 4383 (1934); Feofilaktov, Onishchenko, J. Gen. Chem. USSR 9, 304 (1939), C.A. 34, 378 (1940); Forman; Johnson, US 2397134 and US 2443827 (1946, 1948 both to U.S. Industrial Chemicals).

Arsonoacetic Acid CAS Registry Number: 107-38-0 胂羧基乙酸

Percent Composition: C 13.06%, H 2.74%, As 40.72%, O 43.48%
Literature References: Prepn from sodium arsenite and sodium chloroacetate: Palmer, J. Am. Chem. Soc. 45, 3023 (1923); Org. Synth. coll. vol. I, 73 (1941).

Thiodiglycolic Acid CAS Registry Number: 123-93-3 2,2'-硫代二乙酸

CAS Name: 2,2'-Thiobis[acetic acid]
Additional Names: dimethylsulfide-a,a'-dicarboxylic acid; mercaptodiacetic acid
Percent Composition: C 32.00%, H 4.03%, O 42.62%, S 21.36%
Literature References: Prepn from sodium chloroacetate and hydrogen sulfide: Loven, Ber. 27, 3059 (1894).

Ammonium Stearate CAS Registry Number: 1002-89-7 硬脂酸铵

CAS Name: Octadecanoic acid ammonium salt
Additional Names: stearic acid ammonium salt
Percent Composition: C 71.70%, H 13.04%, N 4.65%, O 10.61%
Literature References: Prepn from stearic acid and excess 28-30% NH3 soln: Stumpf, Am. Paint J. 38, No. 45, 60, 64, 68 (1954), C.A. 48, 12428b (1954); from stearic acid and ammonium carbonate: Reiling, US 3053867 (1962 to Boston Chem. Prod.).

Pregnenolone CAS Registry Number: 145-13-1 孕烯醇酮

CAS Name: (3b)-3-Hydroxypregn-5-en-20-one
Additional Names: D5-pregnen-3b-ol-20-one; 17b-(1-ketoethyl)-D5-androsten-3b-ol
Percent Composition: C 79.70%, H 10.19%, O 10.11%
Literature References: Prepn from stigmasterol: Butenandt et al., Ber. 67, 1611 (1934); Butenandt, Fleischer, Ber. 70, 96 (1937); from androstenolone: H. Butenandt, J. Schmidt-thome, Ber. 72, 182 (1939); S. Danishefsky et al., J. Org. Chem. 40, 1989 (1975); from D5-3-acetoxyetiocholenic acid chloride: Wettstein, Helv. Chim. Acta 23, 1373 (1940); from diosgenin: Marker, Krueger, J. Am. Chem. Soc. 62, 3349 (1940); Marker et al., ibid. 69, 2173 (1947); from nologenin: eidem, ibid. 2395; by treating a 21-halo-D5-pregnen-3-ol-20-one with a reducing agent: CH 215139 (1941), C.A. 42, 3144 (1948). Crystal structure: J. Bordner et al., Cryst. Struct. Commun. 7, 513 (1978).