其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

o-Thymotic Acid CAS Registry Number: 548-51-6 2-羟基-3-异丙基-6-甲基苯甲酸

CAS Name: 2-Hydroxy-6-methyl-3-(1-methylethyl)benzoic acid
Additional Names: 3-hydroxy-2-p-cymenecarboxylic acid; o-thymotinic acid; 6-methyl-3-isopropylsalicylic acid
Percent Composition: C...
Literature References: Prepn from thymol: Kolbe, Lautemann, Ann. 115, 205 (1861); Spallino, Provenzal, Gazz. Chim. Ital. 39 (II), 326 (1909); Royer et al., Bull. Soc. Chim. Fr. 1955, 1421.

Tris(hydroxymethyl)nitromethane CAS Registry Number: 126-11-4 三羟甲基硝基甲烷

CAS Name: 2-(Hydroxymethyl)-2-nitro-1,3-propanediol
Additional Names: 2-nitro-2-(hydroxymethyl)-1,3-propanediol; trimethylolnitromethane
Percent Composition: C 31.79%, H 6.00%, N 9.27%, O 52...
Literature References: Prepn from trioxymethylene and nitromethane: Boileau, Mem. Poudres 35, Annexe 7-76 (1953).

N,N-Dimethylacetamide CAS Registry Number: 127-19-5 N,N-二甲基乙酰胺(DMAC)

Additional Names: Acetic acid dimethylamide; DMAC
Percent Composition: C 55.15%, H 10.41%, N 16.08%, O 18.36%
Literature References: Prepn from tris(dimethylamido)phosphate and acetic anhydride: Dye, US 2667510 (1954 to Chemstrand); from acetic anhydride and dimethylformamide: Coppinger, J. Am. Chem. Soc. 76, 1372 (1954). Toxicity study: W. Bartsch et al., Arzneim.-Forsch. 26, 1581 (1976).

Bromisovalum CAS Registry Number: 496-67-3 1-(2-溴异戊酰)脲

CAS Name: N-(Aminocarbonyl)-2-bromo-3-methylbutanamide
Additional Names: (a-bromoisovaleryl)urea; 2-monobromoisovalerylurea; a-bromo-b-dimethylpropanoylurea; bromvaletone; B.V.U.
Trademarks:...
Literature References: Prepn from urea and a-bromoisovaleryl bromide: US 914518 (1909). Toxicity: R. I. Mrongovius et al., Clin. Exp. Pharmacol. Physiol. 3, 443 (1976).

Pentagestrone CAS Registry Number: 7001-56-1 喷他孕酮

CAS Name: 3-(Cyclopentyloxy)-17-hydroxypregna-3,5-dien-20-one
Additional Names: 17a-hydroxyprogesterone 3-cyclopentyl enol ether
Percent Composition: C 78.35%, H 9.61%, O 12.04%
Literature References: Prepn of acetate: Ercoli, Gardi, J. Am. Chem. Soc. 82, 746 (1960); of free alcohol and acetate: Ercoli, US 3019241 (1962).

Isomethadol CAS Registry Number: 25117-79-7 6-(二甲基氨基)-5-甲基-4,4-二苯基-3-己醇

CAS Name: b-[2-(Dimethylamino)-1-methylethyl]-a-ethyl-b-phenylbenzeneethanol
Additional Names: 6-(dimethylamino)-5-methyl-4,4-diphenyl-3-hexanol; 1-dimethylamino-2-methyl-3,3-diphenyl-4-hexanol...
Literature References: Prepn of a-dl-form by lithium aluminum hydride reduction of dl-isomethadone: May, Mosettig, J. Org. Chem. 13, 663 (1948). Prepn of a-isomers by lithium aluminum hydride reduction of the optical isomers and of b-isomers by sodium-propanol reduction: May, Eddy, ibid. 17, 1210 (1952). Stereochemistry of isomers: Portoghese, Williams, Tetrahedron Lett. 1966, 6299.

Chromic Nitrate CAS Registry Number: 13548-38-4 ICP的铬(III)标准

CAS Name: Nitric acid chromium(3+) salt
Additional Names: chromium(III) nitrate
Percent Composition: Cr 21.85%, N 17.65%, O 60.50%
Literature References: Prepn of anhydr salt from N2O5 and Cr(CO)6: Addison, Chapma, J. Chem. Soc. 1964, 539. Prepn of nonahydrate from Cr(OH)3 and dil HNO3 or by reducing CrO3 in the presence of HNO3: ACS Monograph Series no. 132, entitled "Chromium," vol. 1, M. J. Udy, Ed. (Reinhold, New York, 1956) pp 203-204. Toxicity study: Smyth et al., Am. Ind. Hyg. Assoc. J. 30, 470 (1969).

Indium Telluride CAS Registry Number: 1312-45-4 三碲化二铟

Percent Composition: In 37.50%, Te 62.50%
Literature References: Prepn of black brittle crystals by double furnace technique: Inuzuka, Sugaike, Proc. Jpn. Acad. 30, 383 (1954), C.A. 49, 2922e (1955).

Butylparaben CAS Registry Number: 94-26-8 对羟基苯甲酸丁酯

CAS Name: 4-Hydroxybenzoic acid butyl ester
Additional Names: n-butyl p-hydroxybenzoate
Trademarks: Butyl Chemosept; Butyl Parasept; Tegosept B
Percent Composition: C 68.02%, H 7.27%, O 2...
Literature References: Prepn of calcium and magnesium salts: Engels, Weijlard, US 2046324 and US 2056176 (both 1936 to Merck Co.). Prepn of analogous derivatives: See ethyl-, methyl- and propylparaben.

Thiothixene CAS Registry Number: 5591-45-7 氨砜噻吨

CAS Name: N,N-Dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]thioxanthene-2-sulfonamide
Additional Names: cis9-[3-(4-methyl-1-piperazinyl)propylidene]-2-(dimethylsulfonamido)thioxanthene; ti...
Literature References: Prepn of cis/trans-isomer mixture and sepn of isomers: Bloom, Muren, BE 647066 corresp to US 3310553 (1964, 1967 both to Pfizer); Muren, Bloom, J. Med. Chem. 13, 17 (1970). Only cis-isomer exhibits therapeutic activity. Structure studies: J. P. Schaefer, Chem. Commun. 1967, 743. Pharmacological studies: A. Weissman, Psychopharmacologia 12, 142 (1968). HPLC determn in serum: C. Dilger et al., Arzneim.-Forsch. 38, 1522 (1988). Book: T. A. Ban, Psychopharmacology of Thiothixene (Raven Press, New York, 1978) 485 pp. Comprehensive description: D. K. Wyatt, L. T. Grady, Anal. Profiles Drug Subs. 18, 527-565 (1989).