Acetaminophen CAS Registry Number: 103-90-2 对乙酰氨基苯酚
CAS Name: N-(4-Hydroxyphenyl)acetamide
Additional Names: 4'-hydroxyacetanilide; p-hydroxyacetanilide; p-acetamidophenol; p-acetaminophenol; p-acetylaminophenol; N-acetyl-p-aminophenol; paracetamol
Trademarks: Acamol (Teva); Alpiny (SS Pharm.); Anaflon (GSK); Anhiba (Hokuriku); Apamide (Bayer); Ben-u-ron (Bene-Arzneimittel); Calpol (Pfizer); Captin (Krewel); Dafalgan (UPSA); Datril (BMS); Dirox (Gramon); Disprol (Reckitt Benckiser); Doliprane (Thaplix); Dolprone (Bottu); Enelfa (Dolorgiet); Gelocatil (Gelos); Hedex (GSK); Momentum (Wyeth); Ortensan (Cimex); Panadol (GSK); Panaleve (Pinewood); Panodil (GSK); Paraspen (Pfizer); Pasolind N (Stada); Tempra (BMS); Tylenol (McNeil); Valadol (BMS)
Percent Composition: C 63.57%, H 6.00%, N 9.27%, O 21.17%
📌 参考资料/链接：
Literature References: Prepn from p-nitrophenol: Morse, Ber. 11, 232 (1878); Tingle, Williams, Am. Chem. J. 37, 63 (1907); from p-aminophenol: Lumière et al., Bull. Soc. Chim. Fr. [3] 33, 785 (1905); Fierz-David, Kuster, Helv. Chim. Acta 22, 94 (1939); Wilbert, De Angelis, US 2998450 (1961 to Warner-Lambert); Bergmann, DE 453577; Chem. Zentralbl. 1928, I, 2663; Frdl. 16, 238; from p-hydroxyacetophenone hydrazone: Pearson et al., J. Am. Chem. Soc. 75, 5907 (1953). Toxicity data: G. A. Starmer et al., Toxicol. Appl. Pharmacol. 19, 20 (1971); D. C. Dahlin, S. D. Nelson, J. Med. Chem. 25, 885 (1982). Evaluation of renal effects: D. P. Sandler et al., N. Engl. J. Med. 320, 1238 (1989). Comprehensive description: J. E. Fairbrother, Anal. Profiles Drug Subs. 3, 1-109 (1974). Review of pharmacology: B. Ameer, D. J. Greenblatt, Ann. Intern. Med. 87, 202-209 (1977). Review of acetaminophen-induced hepatotoxicity: J. A. Hinson, Rev. Biochem. Toxicol. 2, 103-129 (1980); idem, Life Sci. 29, 107-116 (1981); and proposed protective agents: M. Davis, Semin. Liver Dis. 6, 138-147 (1986). For proposed toxic metabolite see Acetimidoquinone.
📄 详细内容
Properties: Large monoclinic prisms from water, mp 169-170.5°. d421 1.293. uv max (ethanol): 250 nm (e 13800). Very slightly sol in cold water, considerably more sol in hot water. Sol in methanol, ethanol, dimethylformamide, ethylene dichloride, acetone, ethyl acetate. Slightly sol in ether. Practically insol in petr ether, pentane, benzene. LD50 in mice (mg/kg): 338 orally (Starmer), 500 i.p. (Dahlin, Nelson).
Melting point: mp 169-170.5°
Absorption maximum: uv max (ethanol): 250 nm (e 13800)
Density: d421 1.293
Toxicity data: LD50 in mice (mg/kg): 338 orally (Starmer), 500 i.p. (Dahlin, Nelson)
Use: Manuf azo dyes, photographic chemicals.
Therap-Cat: Analgesic; antipyretic.
Keywords: Analgesic (Non-Narcotic); Antipyretic.
产品链接: 103-90-2››