其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Chloral Formamide CAS Registry Number: 515-82-2 氯醛甲酰胺

CAS Name: N-(2,2,2-Trichloro-1-hydroxyethyl)formamide
Additional Names: chloralamide; chloramide
Percent Composition: C 18.72%, H 2.10%, Cl 55.27%, N 7.28%, O 16.63%
Literature References: Prepn or manuf from chloral and formamide: Bennett, Campbell, Q. J. Pharm. Pharmacol. 8, 398 (1955); and herbicidal activity: Reuter, Sehring, DE 1168161 (1964 to Boehringer, Ing.), C.A. 62, 1024g (1965).

Chlormezanone CAS Registry Number: 80-77-3 氯美扎酮

CAS Name: 2-(4-Chlorophenyl)tetrahydro-3-methyl-4H-1,3-thiazin-4-one 1,1-dioxide
Additional Names: 2-(p-chlorophenyl)perhydro-3-methyl-1,3-thiazin-4-one 1,1-dioxide; 2-(4-chlorophenyl)-3-methyl...
Literature References: Prepn starting with 4-chlorobenzylidenemethylamine: Surrey et al., J. Am. Chem. Soc. 80, 3469 (1958); GB 815203 (1959 to Sterling Drug).

Sulfamethoxazole CAS Registry Number: 723-46-6 磺胺甲噁唑

CAS Name: 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide
Additional Names: N1-(5-methyl-3-isoxazolyl)sulfanilamide; 5-methyl-3-sulfanilamidoisoxazole; 3-sulfanilamido-5-methylisoxazole; 3-...
Literature References: Prepn starting with ethyl 5-methylisoxazole-3-carbamate: Kano et al., US 2888455 (1959 to Shionogi); Annu. Rep. Shionogi Res. Lab. 7, 1 (1957), C.A. 51, 17889 (1957). Toxicity data: Yamamoto et al., Chemotherapy (Tokyo) 21, 187 (1973), C.A. 79, 73738n (1973). Clinical trial of mixture with trimethoprim in Pneumocystis carinii pneumonia: J. M. Wharton et al., Ann. Intern. Med. 105, 37 (1986). Comprehensive description: B. C. Rudy, B. Z. Senkowski, Anal. Profiles Drug Subs. 2, 467-486 (1973). Review of antibacterial activity and clinical efficacy of mixture with trimethoprim: G. P. Wormser et al., Drugs 24, 459-518 (1982). Symposium on clinical intravenous therapy: Rev. Infect. Dis. 9, Suppl. 2, S152-S229 (1987).

Stepronin CAS Registry Number: 72324-18-6 司替罗宁

CAS Name: N-[1-Oxo-2-[(2-thienylcarbonyl)thio]propyl]glycine
Additional Names: 2-(a-thenoylthio)propionylglycine; N-(2-mercaptopropionyl)glycine 2-thiophenecarboxylate (ester); TTPG; prostenogl...
Literature References: Prepn, properties and toxicology: F. Bolasco, BE 875186; eidem, US 4242354 (1979, 1980 to Mediolanum Farmaceutici). Clinical trials in bronchitis: M. Lingetti et al., Int. J. Clin. Pharmacol. Res. 1, 273 (1981); F. Dotta et al., Clin. Ter. 105, 307 (1983); G. C. Morandini et al., Curr. Ther. Res. 35, 783 (1984). Effect on human lung mucus: M. C. Morale et al., Int. J. Tissue React. 5, 231 (1983).

Danthron CAS Registry Number: 117-10-2 1,8-二羟基蒽醌

CAS Name: 1,8-Dihydroxy-9,10-anthracenedione
Additional Names: 1,8-dihydroxyanthraquinone; 1,8-Dihydroxyanthraquinone; chrysazin; dantron
Trademarks: Altan; Antrapurol; Diaquone; Istizin (Wi...
Literature References: Prepn. Fierz-David, Blangey, Farbenchemie (Vienna, 5th ed., 1943) pp 224-225; Kozlov, Dokl. Akad. Nauk SSSR 61, 281 (1948). Clinical trial with poloxalkol in constipation: L. Mundow, Br. J. Clin. Pract. 29, 95 (1975). Mutation study: J. P. Brown, R. J. Brown, Mutat. Res. 40, 203 (1976). Toxicology: M. T. Case et al., Drug Chem. Toxicol. 1, 89 (1977). Review of toxicity and carcinogenic risk: IARC Monographs 50, 265-275 (1990).

Rolicyprine CAS Registry Number: 2829-19-8 罗利普令

CAS Name: 5-Oxo-N-(2-phenylcyclopropyl)-2-pyrrolidinecarboxamide
Additional Names: D-N-(trans-2-phenylcyclopropyl)-L-5-pyrrolidone-2-carboxamide; rolicypramPercent Composition: C 68.83%, H 6.60...
Literature References: Prepn: (isomer obtained not specified) GB 961313 (1964 to Lakeside Labs.); GB 1000895 (1965 to Colgate-Palmolive); Biel, US 3192229 (1965 to Colgate-Palmolive). Prepn of other stereoisomers: Biel, loc. cit. Toxicity study: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).

Benzbromarone CAS Registry Number: 3562-84-3 苯溴马隆

CAS Name: (3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-3-benzofuranyl)methanone
Additional Names: 3,5-dibromo-4-hydroxyphenyl 2-ethyl-3-benzofuranyl ketone; 3-(3,5-dibromo-4-hydroxybenzoyl)-2-ethylben...
Literature References: Prepn: BE 553621 (1957 to Labaz); Buu-Hoi et al., J. Chem. Soc. 1957, 625; Buu-Hoi, Beaudet, US 3012042 (1961 to Soc. Belge l'Azote Prod. Chim. Marly). Structure-activity study: Delbarre et al., Chim. Ther. 3, 470 (1968). Pharmacology of hypouricemic effect: D. S. Sinclair, I. H. Fox, J. Rheumatol. 2, 437 (1975). Pharmacokinetic and clinical studies: T. F. Yu, ibid. 3, 305 (1976). Pharmacokinetics and biotransformation in man: H. Ferber et al., Eur. J. Clin. Pharmacol. 19, 431 (1981). HPLC determn in serum: H. Vergin et al., J. Chromatogr. 183, 383 (1980).

Fenitrothion CAS Registry Number: 122-14-5 杀螟硫磷

CAS Name: Phosphorothioic acid O,O-dimethyl O-(3-methyl-4-nitrophenyl) ester
Additional Names: O,O-dimethyl O-4-nitro-m-tolyl phosphorothioate; O,O-dimethyl O-(3-methyl-4-nitrophenyl) phosphoro...
Literature References: Prepn: BE 594669 (1960 to Sumitomo); BE 596091 (1960 to Bayer). Activity: Y. Nishizawa et al., Agric. Biol. Chem. 25, 605 (1961). Toxicity study: G. Schrader, Angew. Chem. 73, 331 (1961).

Bamifylline CAS Registry Number: 2016-63-9 苄乙醇胺嘌呤

CAS Name: 7-[2-[Ethyl(2-hydroxyethyl)amino]ethyl]-3,7-dihydro-1,3-dimethyl-8-(phenylmethyl)-1H-purine-2,6-dione
Additional Names: 8-benzyl-7-[2-[ethyl(2-hydroxyethyl)amino]ethyl]theophylline; 8...
Literature References: Prepn: BE 602888 (1961 to Christiaens), C.A. 56, 5981c (1962). Pharmacology: Georges et al., Therapie 17, 211 (1962). Metabolism: Dodion et al., Arzneim.-Forsch. 19, 785 (1969). Toxicological studies: Georges et al., ibid. 18, 460 (1968).

Glymidine CAS Registry Number: 339-44-6 格列嘧啶

CAS Name: N-[5-(2-Methoxyethoxy)-2-pyrimidinyl]benzenesulfonamide
Additional Names: 2-benzenesulfonamido-5-(b-methoxyethoxy)pyrimidine; glycodiazine
Percent Composition: C 50.47%, H 4.89%, N...
Literature References: Prepn: BE 609270; H. Priewe et al., US 3275635 (1962, 1966 both to Schering, AG); Gutsche et al., Arzneim.-Forsch. 14, 373 (1964). Series of articles on pharmacology: ibid. 377-412. Activity: Losert et al., ibid. 23, 1251 (1973). Metabolism: Soyfer et al., Chim. Ther. 5, 441 (1970). Toxicity data: Kramer et al., Arzneim.-Forsch. 14, 377 (1964).